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  • SAGE Publications  (4)
  • Wang, Yuhui  (4)
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  • SAGE Publications  (4)
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  • 1
    Online Resource
    Online Resource
    The Noncircadian Function of the Circadian Clock Gene in the Regulation of Male Fertility
    SAGE Publications ; 2013
    In:  Journal of Biological Rhythms Vol. 28, No. 3 ( 2013-06), p. 208-217
    Details
    In: Journal of Biological Rhythms, SAGE Publications, Vol. 28, No. 3 ( 2013-06), p. 208-217
    Abstract: Mice homozygous for a dominant-negative allele of the Clock gene ( Clock Δ 19/Δ 19 ) have slightly but significantly decreased male fertility. The molecular mechanism for this reduction in fertility is unknown. In the present study, we used a small hairpin RNA (shRNA) strategy to specifically knock down the Clock gene expression in the testes of male mice and determined its effect on male fertility. Clock knockdown led to smaller litter size, a lower in vitro fertility rate, lower blastula formation rate, and lower acrosin activity of the knockdown sperm. Locomotor activity analysis of the Clock knockdown mice revealed that Clock knockdown in testes did not alter their circadian rhythm. Taken together, these results provide the first evidence that Clock gene expression in round spermatids is essential for maintaining male reproductivity and suggest that acrosin may be a novel regulatory target of the Clock gene that would regulate the fertilization and early embryonic development to blastula. These findings may provide new clues for development of novel male contraceptive strategies.
    Type of Medium: Online Resource
    ISSN: 0748-7304 , 1552-4531
    URL: Article
    DOI: 10.1177/0748730413486873
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2018064-0
    SSG: 12
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Dynamic damage analysis of airfoil flutter for a generic hypersonic flight vehicle
    SAGE Publications ; 2019
    In:  Journal of Vibration and Control Vol. 25, No. 18 ( 2019-09), p. 2423-2434
    Details
    In: Journal of Vibration and Control, SAGE Publications, Vol. 25, No. 18 ( 2019-09), p. 2423-2434
    Abstract: The main aim of this paper is to establish the relationship between the airfoil flutter with the flight dynamics of a generic hypersonic flight vehicle (HFV) and analyze the airfoil damage variation during the airfoil flutter. Based on the motion equations of the two degrees of freedom airfoil model and the longitudinal dynamics of the HFV, an airfoil dynamic model is established. By using a coupling equation, the relationship between airfoil flutter and the flight dynamics is estimated. According to the stress–strain ([Formula: see text]) model and the strain–fatigue damage ([Formula: see text] ) model, the influence of the stress on the airfoil flutter damage is analyzed. The simulation results show that the flutter of the airfoil is closely related to the flight dynamics for the HFV and the airfoil flutter damage is closely related to the flutter amplitude of the airfoil.
    Type of Medium: Online Resource
    ISSN: 1077-5463 , 1741-2986
    URL: Article
    DOI: 10.1177/1077546319856142
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2070247-4
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  • 3
    Online Resource
    Online Resource
    Damage-mitigating control of hypersonic flight vehicle based on prescribed performance
    SAGE Publications ; 2019
    In:  International Journal of Damage Mechanics Vol. 28, No. 5 ( 2019-05), p. 794-811
    Details
    In: International Journal of Damage Mechanics, SAGE Publications, Vol. 28, No. 5 ( 2019-05), p. 794-811
    Abstract: The goal of damage-mitigating control is to enhance the service life of complex mechanical systems without any significant performance loss. A prescribed performance damage-mitigating controller is designed in this paper to mitigate the damage during longitudinal tracking control of a generic hypersonic flight vehicle. Based on the analysis of stress conditions of wing and construction of damage accumulation model, a hierarchical damage-mitigating controller is designed using prescribed performance which ensures the robustness of performance even after damage-mitigation. Simulation results are presented to show that after damage information feedback, the dynamic performance of the flight is maintained and the damage accumulation is vastly reduced.
    Type of Medium: Online Resource
    ISSN: 1056-7895 , 1530-7921
    URL: Article
    DOI: 10.1177/1056789518793492
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2052623-4
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  • 4
    Online Resource
    Online Resource
    Longitudinal coordination control of hypersonic vehicle based on dynamic equation
    SAGE Publications ; 2019
    In:  Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering Vol. 233, No. 14 ( 2019-11), p. 5205-5216
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering, SAGE Publications, Vol. 233, No. 14 ( 2019-11), p. 5205-5216
    Abstract: The complex nonlinearities of hypersonic vehicles can lead to strong couplings between variables, which will bring great challenges to flight control. For this purpose, this paper proposes a novel coupling analysis method for the longitudinal dynamics of a hypersonic vehicle, based on which a coordination controller is designed to reduce the negative effects of the couplings. Initially, according to the coupling characteristics of the hypersonic vehicle, a novel coupling analysis method based on the dynamic equations is proposed to describe the dynamic coupling relationships between variables. Then, a coordination control scheme is designed by combining sliding mode control and the dynamic coupling matrix obtained. Subsequently, the asymptotic stability of the closed-loop system is proved by using Lyapunov theory, and the simulation results are given to verify the effectiveness of the proposed dynamic coupling matrix-based coordination control.
    Type of Medium: Online Resource
    ISSN: 0954-4100 , 2041-3025
    URL: Article
    DOI: 10.1177/0954410019844432
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2032759-6
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