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  • Wiley  (5)
  • Wang, Yingfei  (5)
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  • Wiley  (5)
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  • 1
    Online Resource
    Online Resource
    Origin and Mechanism of Piezoelectric and Photovoltaic Effects in (111) Polar Orientated NiO Films
    Wiley ; 2023
    In:  Advanced Science
    Details
    In: Advanced Science, Wiley
    Abstract: Based on the current piezoelectric theory, NiO with the centrosymmetric structure is not piezoelectric. However, herein, this study shows the first observation of piezoelectric generation, rectifyingand bulk photovoltaic behaviors in NiO films with [111] orientation and the change in NiO crystal structure in piezoelectric process. The piezoelectric generation, rectifying, and bulk photovoltaic performances are enhanced by increasing (111) orientation, and attenuated and eliminated by applying a persistent stress on the NiO film. The NiO [111] is polar direction, and thus a spontaneous electric field (E S ) is in the NiO film with [111] orientation. The existence of Es in (111) oriented NiO film is found to be the physical basis of the piezoelectric generators and photovoltaic and rectifying effects. Thus, NiO piezoelectric, rectifying, and bulk photovoltaic mechanism are presented at the atomic level. The mechanism may rewrite the current piezoelectric theory, and establish a unified theory of polar structure with wide implications. The polar‐orientated films can be used to fabricate piezoelectric generators and other optoelectronic devices with high performances.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Article
    DOI: 10.1002/advs.202304637
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2808093-2
    Location Call Number Limitation Availability
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Emerging role of PARP‐1 and PARthanatos in ischemic stroke
    Wiley ; 2022
    In:  Journal of Neurochemistry Vol. 160, No. 1 ( 2022-01), p. 74-87
    Details
    In: Journal of Neurochemistry, Wiley, Vol. 160, No. 1 ( 2022-01), p. 74-87
    Abstract: Cell death is a key feature of neurological diseases, including stroke and neurodegenerative disorders. Studies in a variety of ischemic/hypoxic mouse models demonstrate that poly(ADP‐ribose) polymerase 1 (PARP‐1)‐dependent cell death, also named PARthanatos, plays a pivotal role in ischemic neuronal cell death and disease progress. PARthanatos has its unique triggers, processors, and executors that convey a highly orchestrated and programmed signaling cascade. In addition to its role in gene transcription, DNA damage repair, and energy homeostasis through PARylation of its various targets, PARP‐1 activation in neuron and glia attributes to brain damage following ischemia/reperfusion. Pharmacological inhibition or genetic deletion of PARP‐1 reduces infarct volume, eliminates inflammation, and improves recovery of neurological functions in stroke. Here, we reviewed the role of PARP‐1 and PARthanatos in stroke and their therapeutic potential. image
    Type of Medium: Online Resource
    ISSN: 0022-3042 , 1471-4159
    URL: Issue
    URL: Article
    DOI: 10.1111/jnc.v160.1
    DOI: 10.1111/jnc.15464
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2020528-4
    SSG: 12
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    Online Resource
  • 3
    Online Resource
    Online Resource
    NIR‐II Light Powered Asymmetric Hydrogel Nanomotors for Enhanced Immunochemotherapy
    Wiley ; 2023
    In:  Angewandte Chemie Vol. 135, No. 3 ( 2023-01-16)
    Details
    In: Angewandte Chemie, Wiley, Vol. 135, No. 3 ( 2023-01-16)
    Abstract: Nanomotors are appealing drug carriers, and the strength of the propelling force is important for their motion capability. Though high motion efficiency has been achieved with 808 nm light driven Janus‐structured noble metal nanomotors, the NIR‐I light penetration depth and material biocompatibility limit their broad application. Herein, we develop a 1064 nm NIR‐II light driven asymmetric hydrogel nanomotor (AHNM) with high motion capability and load it with doxorubicin for enhanced immunochemotherapy. Magnetic field assisted photopolymerization generates an asymmetric distribution of Fe 3 O 4 @Cu 9 S 8 nanoparticles in the AHNM, producing self‐thermophoresis as driving force under NIR‐II irradiation. The AHNM is also functionalized with dopamine for the capture and retention of tumor‐associated antigens to boost immune activation. The as‐obtained NIR‐II light driven AHNM has a high tumor tissue penetration capability and enhances immunochemotherapy, providing a promising strategy for cancer therapy.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v135.3
    DOI: 10.1002/ange.202212866
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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    Online Resource
  • 4
    Online Resource
    Online Resource
    NIR‐II Light Powered Asymmetric Hydrogel Nanomotors for Enhanced Immunochemotherapy
    Wiley ; 2023
    In:  Angewandte Chemie International Edition Vol. 62, No. 3 ( 2023-01-16)
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 62, No. 3 ( 2023-01-16)
    Abstract: Nanomotors are appealing drug carriers, and the strength of the propelling force is important for their motion capability. Though high motion efficiency has been achieved with 808 nm light driven Janus‐structured noble metal nanomotors, the NIR‐I light penetration depth and material biocompatibility limit their broad application. Herein, we develop a 1064 nm NIR‐II light driven asymmetric hydrogel nanomotor (AHNM) with high motion capability and load it with doxorubicin for enhanced immunochemotherapy. Magnetic field assisted photopolymerization generates an asymmetric distribution of Fe 3 O 4 @Cu 9 S 8 nanoparticles in the AHNM, producing self‐thermophoresis as driving force under NIR‐II irradiation. The AHNM is also functionalized with dopamine for the capture and retention of tumor‐associated antigens to boost immune activation. The as‐obtained NIR‐II light driven AHNM has a high tumor tissue penetration capability and enhances immunochemotherapy, providing a promising strategy for cancer therapy.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v62.3
    DOI: 10.1002/anie.202212866
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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    Online Resource
  • 5
    Online Resource
    Online Resource
    Single‐cell RNA‐sequencing technology demonstrates the heterogeneity between aged prostate peripheral and transitional zone
    Wiley ; 2022
    In:  Clinical and Translational Medicine Vol. 12, No. 10 ( 2022-10)
    Details
    In: Clinical and Translational Medicine, Wiley, Vol. 12, No. 10 ( 2022-10)
    Abstract: Identifying cellular and functional heterogeneity within aged prostate is critical for understanding the spatial distribution of prostate diseases. Methods Aged human prostate peripheral zone (PZ) and transitional zone (TZ) tissues were used for single‐cell RNA‐sequencing. Results were validated by immunofluorescence staining. Results We found that club/hillock epithelial cells, compared with other epithelial cells, had significantly higher NOTCH signaling activity and expressed higher levels of neuro‐stems but lower androgen‐related genes. These cells were primarily found in the TZ and provided a stem‐like niche around the proximal prostate ducts. Significant heterogeneity was observed in the aged luminal population. A novel TFF3+ luminal subtype with elevated MYC and E2F pathway activities was observed, primarily in the PZ. Further analysis revealed that epithelial cells in the TZ had higher levels of stem‐ and inflammation‐related pathway activities but lower androgen/lineage‐related pathway activities than those in the PZ. Notably, the activation of MYC, E2F and DNA repair pathways significantly increased in PZ luminal cells. In the immune landscape, we found that the immune microenvironment in the TZ is more complex and disordered with more infiltration of NK and Treg cells. CD8 T cell and macrophage in the TZ exhibit both inflammation activation and suppression phenotypes. In the stroma, the TZ had a higher fibroblast density, and fibroblasts in the TZ exhibited stronger transcriptome activity in immunity and proliferation. Ligand–receptor interaction analysis revealed that fibroblasts could contribute to a NOTCH signaling niche for club/hillock cells in the TZ and balance the prostate immune microenvironment. The activation of stem properties, inflammatory infiltration and loss of androgen/lineage activity are prominent features distinguishing the TZ from PZ. Conclusions Our study explains the heterogeneity between the TZ and PZ of aged prostate, which may help understand the spatial distribution of prostate diseases and establish a foundation for novel target discovery.
    Type of Medium: Online Resource
    ISSN: 2001-1326 , 2001-1326
    URL: Issue
    URL: Article
    DOI: 10.1002/ctm2.v12.10
    DOI: 10.1002/ctm2.1084
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2697013-2
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    Online Resource
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