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  • SAGE Publications  (34)
  • Wang, Yi  (34)
  • 1
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    Online Resource
    Profile of Chinese Cluster Headache Register Individual Study (CHRIS): Clinical characteristics, diagnosis and treatment status data of 816 patients in China
    SAGE Publications ; 2024
    In:  Cephalalgia Vol. 44, No. 3 ( 2024-03)
    Details
    In: Cephalalgia, SAGE Publications, Vol. 44, No. 3 ( 2024-03)
    Abstract: The clinical profile of cluster headache may differ among different regions of the world, warranting interest in the data obtained from the initial Chinese Cluster Headache Register Individual Study (CHRIS) for better understanding. Methods We conducted a multicenter, prospective, longitudinal cohort study on cluster headache across all 31 provinces of China, aiming to gather clinical characteristics, treatment approaches, imaging, electrophysiological and biological samples. Results In total 816 patients were enrolled with a male-to-female ratio of 4.33:1. The mean age at consultation was 34.98 ± 9.91 years, and 24.89 ± 9.77 years at onset. Only 2.33% were diagnosed with chronic cluster headache, and 6.99% had a family history of the condition. The most common bout was one to two times per year (45.96%), lasting two weeks to one month (44.00%), and occurring frequently in spring (76.23%) and winter (73.04%). Of these, 68.50% experienced one to two attacks per day, with the majority lasting one to two hours (45.59%). The most common time for attacks was between 9 am and 12 pm (75.86%), followed by 1 am and 3 am (43.48%). Lacrimation (78.80%) was the most predominant autonomic symptom reported. Furthermore, 39.22% of patients experienced a delay of 10 years or more in receiving a correct diagnosis. Only 35.67% and 24.26% of patients received common acute and preventive treatments, respectively. Conclusion Due to differences in ethnicity, genetics and lifestyle conditions, CHRIS has provided valuable baseline data from China. By establishing a dynamic cohort with comprehensive multidimensional data, it aims to advance the management system for cluster headache in China.
    Type of Medium: Online Resource
    ISSN: 0333-1024 , 1468-2982
    URL: Article
    DOI: 10.1177/03331024241235193
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2024
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  • 2
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    Clinical study of the relationship between γ-synuclein and the response of neoadjuvant chemotherapy in breast cancer
    SAGE Publications ; 2013
    In:  Journal of International Medical Research Vol. 41, No. 3 ( 2013-06), p. 743-753
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 41, No. 3 ( 2013-06), p. 743-753
    Abstract: To investigate relationships between several protein biomarkers and clinical responses to neoadjuvant chemotherapy (NAC) in breast cancer. Methods Tumour tissue samples from female patients with locally advanced breast carcinoma (stages IIA to IIIC), treated with NAC regimens (including 5-fluorouracil, epirubicin, cyclophosphamide and docetaxel, epirubicin, cyclophosphamide) were analysed retrospectively. Immunohistochemical analysis was used to test for protein levels of oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor (HER)-2, protein 53 (p53) and γ-synuclein. Relationships between protein biomarkers and responses to NAC were analysed by multivariate logistic regression analysis. Results Data from 154 patients (median age, 51 years; range 27–75 years) were included. Multivariate logistic regression analysis showed that γ-synuclein was an independent predictor of NAC objective response rate, and a statistically significant relationship was observed between NAC regimen, γ-synuclein levels and pathological complete response rate. Conclusions These study findings suggest that γ-synuclein – in combination with other markers such as ER, PR and HER-2 – may serve as a biomarker for response to NAC in breast cancer and warrants further study.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060513484434
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
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    detail.hit.zdb_id: 2082422-1
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  • 3
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    Establishing an hTERT-driven immortalized umbilical cord-derived mesenchymal stem cell line and its therapeutic application in mice with liver failure
    SAGE Publications ; 2023
    In:  Journal of Tissue Engineering Vol. 14 ( 2023-01)
    Details
    In: Journal of Tissue Engineering, SAGE Publications, Vol. 14 ( 2023-01)
    Abstract: Acute liver failure (ALF) is characterized by rapid liver cell destruction. It is a multi-etiological and fulminant complication with a clinical mortality of over 80%. Therapy using mesenchymal stem cells (MSCs) or MSCs-derived exosomes can alleviate acute liver injury, which has been demonstrated in animal experiments and clinical application. However, similar to other stem cells, different cell sources, poor stability, cell senescence and other factors limit the clinical application of MSCs. To achieve mass production and quality control on stem cells and their exosomes, transfecting umbilical cord mesenchymal stem cell (UCMSC) with lentivirus overexpressing human telomerase reverse transcriptase (hTERT) gene, the hTERT-UCMSC was constructed as an immortalized MSC cell line. Compared with the primary UCMSC (P3) and immortalized cell line hTERT-UCMSC at early passage (P10), the hTERT-UCMSC retained the key morphological and physiological characteristics of UCMSC at the 35th passage (P35), and showed no signs of carcinogenicity and toxic effect in mice. There was no difference in either exosome production or characteristics of exosomes among cultures from P3 primary cells, P10 and P35 immortalized hTERT-UCMSCs. Inoculation of either hTERT-UCMSC (P35) or its exosomes improved the survival rate and liver function of ALF mice induced by thioacetamide (TAA). Our findings suggest that this immortalized cell line can maintain its characteristics in long-term culture. Inoculation of hTERT-UCMSC and its exosomes could potentially be used in clinics for the treatment of liver failure in the future.
    Type of Medium: Online Resource
    ISSN: 2041-7314 , 2041-7314
    URL: Article
    DOI: 10.1177/20417314231200328
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2573915-3
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  • 4
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    Psychometric properties of the Chinese Parent Version of the Autism Spectrum Rating Scale: Rasch analysis
    SAGE Publications ; 2021
    In:  Autism Vol. 25, No. 7 ( 2021-10), p. 1872-1884
    Details
    In: Autism, SAGE Publications, Vol. 25, No. 7 ( 2021-10), p. 1872-1884
    Abstract: The recent adaptation of a Chinese parent version of the Autism Spectrum Rating Scale showed the Modified Chinese Autism Spectrum Rating Scale to be reliable and valid for use in China. The aim of this study was to test the Modified Chinese Autism Spectrum Rating Scale for fit to the Rasch model. We analysed data from a previous study of the Modified Chinese Autism Spectrum Rating Scale which comprised 1593 non-cases and 420 children diagnosed with autism spectrum disorder. We used super items based on groups of locally dependent items and item deletion when necessary to achieve good fit to the model for each of the three subscales identified by Zhou et al. and for the full 59-item Modified Chinese Autism Spectrum Rating Scale. The resulting conversion tables enable the use of genuine unidimensional, interval level scores for the total score and three subscales. Reliability was high with Person Separation Index values ranging from 0.83 to 0.89 for the three subscales and 0.79 for the total scale. In addition, we were able to identify a full-scale version of the Autism Spectrum Rating Scale and its three subscales that are all free of differential item functioning in relation to the five person factors recorded namely age, sex, caseness, relative and city. In future studies, the Teacher version of the Modified Chinese Autism Spectrum Rating Scale needs examination with Rasch analysis. Lay abstract The Autism Spectrum Rating Scale is a behavioural rating scale completed by parents and teachers that is useful for identifying children with an autism spectrum disorder. The development of a modified Autism Spectrum Rating Scale suitable for use in China is important for the identification of children in China with an autism spectrum disorder. In this study, we examined the Modified Chinese Autism Spectrum Rating Scale using a statistical technique known as Rasch analysis. Rasch analysis tests whether the questionnaire meets the standards for modern scientific measurement. We used Rasch analysis to examine data from 2013 children in China including 420 diagnosed with an autism spectrum disorder who had been rated by a parent or grandparent. After removing a small number of items (questions), the Modified Chinese Autism Spectrum Rating Scale met the stringent criteria for Rasch measurement. The availability of a reliable and precise tool for assessing behaviours characteristic of an autism spectrum disorder in Chinese children will improve the identification and diagnosis of autism spectrum disorder in China, thus enabling better provision of support services.
    Type of Medium: Online Resource
    ISSN: 1362-3613 , 1461-7005
    URL: Article
    DOI: 10.1177/13623613211004054
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
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    detail.hit.zdb_id: 2034686-4
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  • 5
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    Absence of the celiac trunk: Definition, classification, multidetector computed tomography angiographic findings, and their probable embryological mechanisms
    SAGE Publications ; 2023
    In:  Vascular Vol. 31, No. 6 ( 2023-12), p. 1214-1221
    Details
    In: Vascular, SAGE Publications, Vol. 31, No. 6 ( 2023-12), p. 1214-1221
    Abstract: This study aims to identify the types and prevalence of absence of the celiac trunk by using multidetector computed tomography (MDCT) angiography, and analyze their probable embryological mechanisms. Methods A retrospective study was carried out on 2500 abdominal MDCT angiography images. The absence of the celiac trunk was defined as that the celiac trunk is not exist, more specifically, there is not such an arterial trunk containing at least two major branches of the celiac trunk. Various types of the absence of the celiac trunk were investigated. Results Of the 2500 patients, 19 (0.76%) patients were identified as an absence of the celiac trunk. According to its definition and classification, the absence of the celiac trunk could be divided into five types: type I (LGA + CHA + SA + SMA), type II (HM trunk + LGA + SA), type III (SM trunk + LGA + CHA), type IV (GM trunk + CHA + SA), and type V (other type); and these types were observed in 5 patients (0.20%), 9 patients (0.36%), 3 patients (0.12%), 0 patients (0.00%), and 2 (0.08%) patients, respectively. There were more examples of the types I and II than of the types III–V ( p = 0.004). Conclusion We systematically classified the absence of the celiac trunk based on its MDCT angiography findings. Abnormal interruptions and persistence of the longitudinal anastomosis, regression of vascular root, and emergence of replaced artery could all be the embryological mechanisms of various types of the absence of the celiac trunk.
    Type of Medium: Online Resource
    ISSN: 1708-5381 , 1708-539X
    URL: Article
    DOI: 10.1177/17085381221106318
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2137151-9
    detail.hit.zdb_id: 2143006-8
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  • 6
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    Detection of FHIT and p16 mRNA Deletion in Biopsy Specimens Obtained by Bronchoscopy for the Diagnosis of Lung Cancer
    SAGE Publications ; 2013
    In:  The International Journal of Biological Markers Vol. 28, No. 3 ( 2013-07), p. 259-266
    Details
    In: The International Journal of Biological Markers, SAGE Publications, Vol. 28, No. 3 ( 2013-07), p. 259-266
    Abstract: The purpose of this study was to investigate the diagnostic value of the deletion of fragile histidine triad (FHIT) and p16 INK4a (p16) mRNA in biopsies obtained by bronchoscopy. Biopsies were analyzed using RT-PCR in 52 patients with lung cancer and 19 patients with benign lung disease. The results showed that the detection rates of FHIT and p16 gene transcript deletion were significantly higher in lung cancer patients than in patients with benign lung disease (65.4% versus 10.5%, p=0.001 and 59.6% versus 5.3%, p 〈 0.001, respectively). The sensitivities for detecting FHIT and p16 transcript deletion in biopsies were 65.4% and 59.6% (combined 80.8%), respectively, which were markedly better than those of histology and cytology (42.3% and 34.6%, respectively; combined 57.7%). In 22 lung cancer patients with negative histology and cytology at initial bronchoscopy, FHIT and p16 mRNA loss was detected in 40.9% (9/22) and 36.4% (8/22) cases, respectively. FHIT mRNA loss was associated with smoking status in lung cancer patients. In conclusion, deletion of FHIT and p16 mRNA can be identified in biopsies obtained during bronchoscopic procedures. FHIT and p16 mRNA deletion can be used as biomarkers in the clinical diagnosis of lung cancer and may serve as adjuncts to histology and cytology in lung cancer diagnosis.
    Type of Medium: Online Resource
    ISSN: 1724-6008 , 1724-6008
    URL: Article
    DOI: 10.5301/JBM.5000021
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
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  • 7
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    Using end buckles to improve debonding resistance in FRP-bonded precracked RC beams
    SAGE Publications ; 2023
    In:  Advances in Structural Engineering Vol. 26, No. 1 ( 2023-01), p. 108-120
    Details
    In: Advances in Structural Engineering, SAGE Publications, Vol. 26, No. 1 ( 2023-01), p. 108-120
    Abstract: The strengthening effect of reinforced concrete (RC) members externally bonded (EB) with fiber reinforced polymer (FRP) laminates is significantly affected by interfacial debonding failure. To improve the connection between FRP sheets and concrete, a novel type of anchor device for FRP sheets called buckle was proposed in this study. This device can effectively lock the end of the sheet using a patented method of wrapping. In addition to conventional external bonding, bolts were installed on the buckles to form hybrid anchored (HA) FRP sheet. To verify the effectiveness of this new method, a precracked RC beam was prepared in comparison with two undamaged beams strengthened with EB or HA FRP sheets. As observed, end buckles can limit the development of cracks regardless of initial cracking. Despite the occurrence of intermediate debonding due to initial cracks, both the ultimate capacity and failure ductility were significantly improved. Owing to the end buckles, the debonding resistance was excellent, and the initial cracking of the beam hardly affected the strengthening effect. In addition, existing formulas were used to calculate the lower limit of the ultimate load of the specimen strengthened with HA FRP, which was still higher than that of the specimen strengthened by EB FRP. Therefore, the results confirmed that the debonding resistance was greatly enhanced due to the locking of the FRP sheet via end buckles, and the proposed method is useful to guarantee the strengthening effect.
    Type of Medium: Online Resource
    ISSN: 1369-4332 , 2048-4011
    URL: Article
    DOI: 10.1177/13694332221119878
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
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  • 8
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    A Research Note on Challenges of Cross-National Aging Research: An Example of Productive Activities Across Three Countries
    SAGE Publications ; 2018
    In:  Research on Aging Vol. 40, No. 1 ( 2018-01), p. 54-71
    Details
    In: Research on Aging, SAGE Publications, Vol. 40, No. 1 ( 2018-01), p. 54-71
    Abstract: Cross-national studies can elucidate the influence of sociocultural contexts on a wide variety of aging issues. This study aims to develop methods for using secondary data for cross-national comparisons using productive activities as an example. The study also identifies challenges in conducting cross-national research. Using the national representative data from the United States, China, and South Korea, this study developed a sequence of methods for cross-national analysis. Results indicate that productive activities vary by country, and this variation could possibly be due to the differences in sociocultural context and variations in operationalization and measurement. Given the difficulty of making decisions and drawing conclusions across different cultural contexts, team members must include scholars who are familiar with the culture and language of the region of study. Researchers also need to determine whether data sets are valid for cross-national comparisons and understand the limitations of the comparisons, given constraints in the data.
    Type of Medium: Online Resource
    ISSN: 0164-0275 , 1552-7573
    URL: Article
    DOI: 10.1177/0164027516678997
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
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  • 9
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    Chinese guideline on the application of anti-seizure medications in the perioperative period of supratentorial craniocerebral surgery
    SAGE Publications ; 2022
    In:  Therapeutic Advances in Neurological Disorders Vol. 15 ( 2022-01), p. 175628642211143-
    Details
    In: Therapeutic Advances in Neurological Disorders, SAGE Publications, Vol. 15 ( 2022-01), p. 175628642211143-
    Abstract: Seizures are a common symptom of craniocerebral diseases, and epilepsy is one of the comorbidities of craniocerebral diseases. However, how to rationally use anti-seizure medications (ASMs) in the perioperative period of craniocerebral surgery to control or avoid seizures and reduce their associated harm is a problem. The China Association Against Epilepsy (CAAE) united with the Trauma Group of the Chinese Neurosurgery Society, Glioma Professional Committee of the Chinese Anti-Cancer Association, Neuro-Oncology Branch of the Chinese Neuroscience Society, and Neurotraumatic Group of Chinese Trauma Society, and selected experts for consultancy regarding outcomes from evidence-based medicine in domestic and foreign literature. These experts referred to the existing research evidence, drug characteristics, Chinese FDA-approved indications, and expert experience, and finished the current guideline on the application of ASMs during the perioperative period of craniocerebral surgery, aiming to guide relevant clinical practice. This guideline consists of six sections: application scope of guideline, concepts of craniocerebral surgery-related seizures and epilepsy, postoperative application of ASMs in patients without seizures before surgery, application of ASMs in patients with seizures associated with lesions before surgery, emergency treatment of postoperative seizures, and 16 recommendations.
    Type of Medium: Online Resource
    ISSN: 1756-2864 , 1756-2864
    URL: Article
    DOI: 10.1177/17562864221114357
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
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  • 10
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    Development of a Crash Risk-Scoring Tool for Pedestrian and Bicycle Projects in Oregon
    SAGE Publications ; 2018
    In:  Transportation Research Record: Journal of the Transportation Research Board Vol. 2672, No. 32 ( 2018-12), p. 30-39
    Details
    In: Transportation Research Record: Journal of the Transportation Research Board, SAGE Publications, Vol. 2672, No. 32 ( 2018-12), p. 30-39
    Abstract: Methods for identifying and prioritizing high-crash locations for safety improvements are generally crash-based. There are fewer reported crashes involving non-motorized users and, in most states, reported crashes must involve a motor vehicle. This means that minor, non-injury events are not reported and those crashes that are reported tend to be more severe. Selecting projects based only on crash performance is sometimes limiting for these crash types and predicting where these crashes will occur next is also a challenging task. An alternative to crash-based selection is to develop risk-based criteria and methods. This paper presents the results of a research effort to develop a risk-scoring method with weights derived from data for use in project screening and selection in Oregon. To develop the risk model, data were collected from 188 segments and 184 intersections randomly selected on both state and non-state roadways. Geometric, land use, volume, and crash data were collected from Google Earth, EPA’s Smart Location Database, and the Oregon Department of Transportation crash database from 2009 to 2013. The sample included 213 bicycle and pedestrian crashes on the segments and 238 at intersections. Logistic regression models were developed and the outputs used to create pedestrian and bicycle risk-scoring tools for segments and intersections. The risk-scoring tool was applied to safety projects identified in the 2015 All Roads Transportation Safety (ARTS) project lists from Oregon. The risk scores for the case study applications aligned reasonably well with the project’s benefits-costs estimates.
    Type of Medium: Online Resource
    ISSN: 0361-1981 , 2169-4052
    URL: Article
    DOI: 10.1177/0361198118794285
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
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    detail.hit.zdb_id: 2403378-9
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