GLORIA

GEOMAR Library Ocean Research Information Access

X
Your search history is empty.

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Oxford University Press (OUP)  (21)
  • Wang, Yan  (21)
  • 2020-2024  (21)
Material
Publisher
  • Oxford University Press (OUP)  (21)
Person/Organisation
Language
Years
  • 2020-2024  (21)
Year
FID
Subjects(RVK)
  • 1
    Online Resource
    Online Resource
    Corrigendum to: The TianQin project: current progress on science and technology
    Oxford University Press (OUP) ; 2021
    In:  Progress of Theoretical and Experimental Physics Vol. 2021, No. 5 ( 2021-05-18)
    Details
    In: Progress of Theoretical and Experimental Physics, Oxford University Press (OUP), Vol. 2021, No. 5 ( 2021-05-18)
    Type of Medium: Online Resource
    ISSN: 2050-3911
    URL: Article
    DOI: 10.1093/ptep/ptaa165
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2705045-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    The TianQin project: Current progress on science and technology
    Oxford University Press (OUP) ; 2021
    In:  Progress of Theoretical and Experimental Physics Vol. 2021, No. 5 ( 2021-05-18)
    Details
    In: Progress of Theoretical and Experimental Physics, Oxford University Press (OUP), Vol. 2021, No. 5 ( 2021-05-18)
    Abstract: TianQin is a planned space-based gravitational wave (GW) observatory consisting of three Earth-orbiting satellites with an orbital radius of about $10^5 \, {\rm km}$. The satellites will form an equilateral triangle constellation the plane of which is nearly perpendicular to the ecliptic plane. TianQin aims to detect GWs between $10^{-4} \, {\rm Hz}$ and $1 \, {\rm Hz}$ that can be generated by a wide variety of important astrophysical and cosmological sources, including the inspiral of Galactic ultra-compact binaries, the inspiral of stellar-mass black hole binaries, extreme mass ratio inspirals, the merger of massive black hole binaries, and possibly the energetic processes in the very early universe and exotic sources such as cosmic strings. In order to start science operations around 2035, a roadmap called the 0123 plan is being used to bring the key technologies of TianQin to maturity, supported by the construction of a series of research facilities on the ground. Two major projects of the 0123 plan are being carried out. In this process, the team has created a new-generation $17 \, {\rm cm}$ single-body hollow corner-cube retro-reflector which was launched with the QueQiao satellite on 21 May 2018; a new laser-ranging station equipped with a $1.2 \, {\rm m}$ telescope has been constructed and the station has successfully ranged to all five retro-reflectors on the Moon; and the TianQin-1 experimental satellite was launched on 20 December 2019—the first-round result shows that the satellite has exceeded all of its mission requirements.
    Type of Medium: Online Resource
    ISSN: 2050-3911
    URL: Article
    DOI: 10.1093/ptep/ptaa114
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2705045-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    In-hospital outcomes of ticagrelor versus clopidogrel in patients 75 years or older with acute coronary syndrome: findings from the Improving Care for Cardiovascular Disease in China (CCC)–Acute Coronary Syndrome Project
    Oxford University Press (OUP) ; 2022
    In:  Age and Ageing Vol. 51, No. 11 ( 2022-11-01)
    Details
    In: Age and Ageing, Oxford University Press (OUP), Vol. 51, No. 11 ( 2022-11-01)
    Abstract: The evidence for the comparative effectiveness and safety of ticagrelor versus clopidogrel in older patients with acute coronary syndrome (ACS) is limited, especially in the acute phase of ACS. This study aimed to compare the in-hospital outcomes of ticagrelor versus clopidogrel in older patients with ACS. Methods Hospitalised ACS patients aged ≥75 years who were recruited to the Improving Care for Cardiovascular Disease in China-ACS project between November 2014 and December 2019 and received aspirin and P2Y12 receptor inhibitors within 24 h after first medical contact were included. The primary outcomes were in-hospital major adverse cardiovascular events (MACE) and major bleeding. Multivariable Cox regression was performed to evaluate the comparative effectiveness and safety of ticagrelor and clopidogrel. Inverse probability of treatment weighting (IPTW) and propensity score matching analyses were performed to evaluate the robustness of the results. Results Of 18,244 ACS patients, 18.5% received ticagrelor. Multivariable-adjusted analysis revealed comparable risks of in-hospital MACE between patients receiving ticagrelor and clopidogrel (hazard ratio [HR] 1.12, 95% confidence interval [CI] 0.92–1.35). However, ticagrelor use was associated with 45% higher risk of in-hospital major bleeding compared with clopidogrel use (HR 1.45, 95% CI 1.09–1.91). Similar results were found in the IPTW analysis. Conclusions ACS patients aged ≥75 years receiving ticagrelor during the acute phase had similar risk of in-hospital MACE, but higher risk of in-hospital major bleeding compared with those receiving clopidogrel. More evidence is needed to guide the use of P2Y12 receptor inhibitors during hospitalisation in older patients with ACS. Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT02306616.
    Type of Medium: Online Resource
    ISSN: 0002-0729 , 1468-2834
    URL: Article
    DOI: 10.1093/ageing/afac231
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2065766-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Plant-on-chip: Core morphogenesis processes in the tiny plant Wolffia australiana
    Oxford University Press (OUP) ; 2023
    In:  PNAS Nexus Vol. 2, No. 5 ( 2023-05-02)
    Details
    In: PNAS Nexus, Oxford University Press (OUP), Vol. 2, No. 5 ( 2023-05-02)
    Abstract: A plant can be thought of as a colony comprising numerous growth buds, each developing to its own rhythm. Such lack of synchrony impedes efforts to describe core principles of plant morphogenesis, dissect the underlying mechanisms, and identify regulators. Here, we use the minimalist known angiosperm to overcome this challenge and provide a model system for plant morphogenesis. We present a detailed morphological description of the monocot Wolffia australiana, as well as high-quality genome information. Further, we developed the plant-on-chip culture system and demonstrate the application of advanced technologies such as single-nucleus RNA-sequencing, protein structure prediction, and gene editing. We provide proof-of-concept examples that illustrate how W. australiana can decipher the core regulatory mechanisms of plant morphogenesis.
    Type of Medium: Online Resource
    ISSN: 2752-6542
    URL: Article
    DOI: 10.1093/pnasnexus/pgad141
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 3120703-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Zp4 is completely dispensable for fertility in female rats
    Oxford University Press (OUP) ; 2021
    In:  Biology of Reproduction Vol. 104, No. 6 ( 2021-06-04), p. 1282-1291
    Details
    In: Biology of Reproduction, Oxford University Press (OUP), Vol. 104, No. 6 ( 2021-06-04), p. 1282-1291
    Abstract: Zona pellucida (ZP), which is composed of at most four extracellular glycoproteins (ZP1, ZP2, ZP3, and ZP4) in mammals, shelters the oocytes and is vital in female fertility. Several studies have identified the indispensable roles of ZP1–3 in maintaining normal female fertility. However, the understanding of ZP4 is still very poor because only one study on ZP4-associated infertility performed in rabbits has been reported up to date. Here we investigated the function of mammalian Zp4 by creating a knockout (KO) rat strain (Zp4−/− rat) using CRISPR–Cas9-mediated DNA-editing method. The influence of Zp4 KO on ZP morphology and some pivotal processes of reproduction, including oogenesis, ovulation, fertilization, and pup production, were studied using periodic acid–Schiff’s staining, superovulation, in vitro fertilization, and natural mating. The ZP morphology in Zp4−/− rats was normal, and none of these pivotal processes was affected. This study renewed the knowledge of mammalian Zp4 by suggesting that Zp4 was completely dispensable for female fertility.
    Type of Medium: Online Resource
    ISSN: 0006-3363 , 1529-7268
    URL: Article
    DOI: 10.1093/biolre/ioab047
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 1469812-2
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Multicentre, randomized comparison of two-stent and provisional stenting techniques in patients with complex coronary bifurcation lesions: the DEFINITION II trial
    Oxford University Press (OUP) ; 2020
    In:  European Heart Journal Vol. 41, No. 27 ( 2020-07-14), p. 2523-2536
    Details
    In: European Heart Journal, Oxford University Press (OUP), Vol. 41, No. 27 ( 2020-07-14), p. 2523-2536
    Abstract: The present study aimed to assess the benefits of two-stent techniques for patients with DEFINITION criteria-defined complex coronary bifurcation lesions. Methods and results In total, 653 patients with complex bifurcation lesions at 49 international centres were randomly assigned to undergo the systematic two-stent technique (two-stent group) or provisional stenting (provisional group). The primary endpoint was the composite of target lesion failure (TLF) at the 1-year follow-up, including cardiac death, target vessel myocardial infarction (TVMI), and clinically driven target lesion revascularization (TLR). The safety endpoint was definite or probable stent thrombosis. At the 1-year follow-up, TLF occurred in 37 (11.4%) and 20 (6.1%) patients in the provisional and two-stent groups, respectively [77.8%: double-kissing crush; hazard ratio (HR) 0.52, 95% confidence interval (CI) 0.30–0.90; P = 0.019], largely driven by increased TVMI (7.1%, HR 0.43, 95% CI 0.20–0.90; P = 0.025) and clinically driven TLR (5.5%, HR 0.43, 95% CI 0.19–1.00; P = 0.049) in the provisional group. At the 1 year after indexed procedures, the incidence of cardiac death was 2.5% in the provisional group, non-significant to 2.1% in the two-stent group (HR 0.86, 95% CI 0.31–2.37; P = 0.772). Conclusion For DEFINITION criteria-defined complex coronary bifurcation lesions, the systematic two-stent approach was associated with a significant improvement in clinical outcomes compared with the provisional stenting approach. Further study is urgently warranted to identify the mechanisms contributing to the increased rate of TVMI after provisional stenting. Study registration http://www.clinicaltrials.com; Identifier: NCT02284750.
    Type of Medium: Online Resource
    ISSN: 0195-668X , 1522-9645
    URL: Article
    DOI: 10.1093/eurheartj/ehaa543
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 2001908-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Cotton leaf curl Multan virus C4 protein suppresses autophagy to facilitate viral infection
    Oxford University Press (OUP) ; 2023
    In:  Plant Physiology Vol. 193, No. 1 ( 2023-08-31), p. 708-720
    Details
    In: Plant Physiology, Oxford University Press (OUP), Vol. 193, No. 1 ( 2023-08-31), p. 708-720
    Abstract: Autophagy plays an important role in plant antiviral defense. Several plant viruses are reported to encode viral suppressor of autophagy (VSA) to prevent autophagy for effective virus infection. However, whether and how other viruses, in particular DNA viruses, also encode VSAs to affect viral infection in plants is unknown. Here, we report that the C4 protein encoded by Cotton leaf curl Multan geminivirus (CLCuMuV) inhibits autophagy by binding to the autophagy negative regulator eukaryotic translation initiation factor 4A (eIF4A) to enhance the eIF4A—Autophagy-related protein 5 (ATG5) interaction. By contrast, the R54A or R54K mutation in C4 abolishes its capacity to interact with eIF4A, and neither C4R54A nor C4R54K can suppress autophagy. However, the R54 residue is not essential for C4 to interfere with transcriptional gene silencing or post-transcriptional gene silencing. Moreover, plants infected with mutated CLCuMuV-C4R54K develop less severe symptoms with decreased levels of viral DNA. These findings reveal a molecular mechanism underlying how the DNA virus CLCuMuV deploys a VSA to subdue host cellular antiviral autophagy defense and uphold viral infection in plants.
    Type of Medium: Online Resource
    ISSN: 0032-0889 , 1532-2548
    URL: Article
    DOI: 10.1093/plphys/kiad235
    RVK:
    WA 15000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2004346-6
    detail.hit.zdb_id: 208914-2
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Remarkable response of BRAF V600E-mutated metastatic pancreatic cancer to BRAF/MEK inhibition: a case report
    Oxford University Press (OUP) ; 2022
    In:  Gastroenterology Report Vol. 10 ( 2022-01-25)
    Details
    In: Gastroenterology Report, Oxford University Press (OUP), Vol. 10 ( 2022-01-25)
    Type of Medium: Online Resource
    ISSN: 2052-0034
    URL: Article
    DOI: 10.1093/gastro/goab031
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2710871-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    A divide-and-conquer method for sparse risk prediction and evaluation
    Oxford University Press (OUP) ; 2022
    In:  Biostatistics Vol. 23, No. 2 ( 2022-04-13), p. 397-411
    Details
    In: Biostatistics, Oxford University Press (OUP), Vol. 23, No. 2 ( 2022-04-13), p. 397-411
    Abstract: Divide-and-conquer (DAC) is a commonly used strategy to overcome the challenges of extraordinarily large data, by first breaking the dataset into series of data blocks, then combining results from individual data blocks to obtain a final estimation. Various DAC algorithms have been proposed to fit a sparse predictive regression model in the $L_1$ regularization setting. However, many existing DAC algorithms remain computationally intensive when sample size and number of candidate predictors are both large. In addition, no existing DAC procedures provide inference for quantifying the accuracy of risk prediction models. In this article, we propose a screening and one-step linearization infused DAC (SOLID) algorithm to fit sparse logistic regression to massive datasets, by integrating the DAC strategy with a screening step and sequences of linearization. This enables us to maximize the likelihood with only selected covariates and perform penalized estimation via a fast approximation to the likelihood. To assess the accuracy of a predictive regression model, we develop a modified cross-validation (MCV) that utilizes the side products of the SOLID, substantially reducing the computational burden. Compared with existing DAC methods, the MCV procedure is the first to make inference on accuracy. Extensive simulation studies suggest that the proposed SOLID and MCV procedures substantially outperform the existing methods with respect to computational speed and achieve similar statistical efficiency as the full sample-based estimator. We also demonstrate that the proposed inference procedure provides valid interval estimators. We apply the proposed SOLID procedure to develop and validate a classification model for disease diagnosis using narrative clinical notes based on electronic medical record data from Partners HealthCare.
    Type of Medium: Online Resource
    ISSN: 1465-4644 , 1468-4357
    URL: Article
    DOI: 10.1093/biostatistics/kxaa031
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2020601-X
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Brassinosteroid homeostasis is critical for the functionality of the Medicago truncatula pulvinus
    Oxford University Press (OUP) ; 2021
    In:  Plant Physiology Vol. 185, No. 4 ( 2021-04-23), p. 1745-1763
    Details
    In: Plant Physiology, Oxford University Press (OUP), Vol. 185, No. 4 ( 2021-04-23), p. 1745-1763
    Abstract: Many plant species open their leaves during the daytime and close them at night as if sleeping. This leaf movement is known as nyctinasty, a unique and intriguing phenomenon that been of great interest to scientists for centuries. Nyctinastic leaf movement occurs widely in leguminous plants, and is generated by a specialized motor organ, the pulvinus. Although a key determinant of pulvinus development, PETIOLULE-LIKE PULVINUS (PLP), has been identified, the molecular genetic basis for pulvinus function is largely unknown. Here, through an analysis of knockout mutants in barrelclover (Medicago truncatula), we showed that neither altering brassinosteroid (BR) content nor blocking BR signal perception affected pulvinus determination. However, BR homeostasis did influence nyctinastic leaf movement. BR activity in the pulvinus is regulated by a BR-inactivating gene PHYB ACTIVATION TAGGED SUPPRESSOR1 (BAS1), which is directly activated by PLP. A comparative analysis between M. truncatula and the non-pulvinus forming species Arabidopsis and tomato (Solanum lycopersicum) revealed that PLP may act as a factor that associates with unknown regulators in pulvinus determination in M. truncatula. Apart from exposing the involvement of BR in the functionality of the pulvinus, these results have provided insights into whether gene functions among species are general or specialized.
    Type of Medium: Online Resource
    ISSN: 0032-0889 , 1532-2548
    URL: Article
    DOI: 10.1093/plphys/kiab008
    RVK:
    WA 15000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2004346-6
    detail.hit.zdb_id: 208914-2
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...