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  • Hindawi Limited  (7)
  • Wang, Xuemei  (7)
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  • Hindawi Limited  (7)
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  • 1
    In: BioMed Research International, Hindawi Limited, Vol. 2016 ( 2016), p. 1-6
    Abstract: Objective . To validate the ability of 99m Tc-Annexin V to visualize early stage of glucocorticoid-induced femoral head necrosis by comparing with 99m Tc-MDP bone scanning. Methods . Femoral head necrosis was induced in adult New Zealand white rabbits by intramuscular injection of methylprednisolone. 99m Tc-Annexin scintigraphy and 99m Tc-MDP scans were performed before and 5, 6, and 8 weeks after methylprednisolone administration. Rabbits were sacrificed at various time points and conducted for TUNEL and H & E staining. Results . All methylprednisolone treated animals developed femoral head necrosis; at 8 weeks postinjection, destruction of bone structure was evident in H & E staining, and apoptosis was confirmed by the TUNEL assay. This was matched by 99m Tc-Annexin V images, which showed a significant increase in signal over baseline. Serial 99m Tc-Annexin V scans revealed that increased 99m Tc-Annexin V uptake could be observed in 5 weeks. In contrast, there was no effect on 99m Tc-MDP signal until 8 weeks. The TUNEL assay revealed that bone cell apoptosis occurred at 5 weeks. Conclusion . 99m Tc-Annexin V is superior to 99m Tc-MDP for the early detection of glucocorticoid-induced femoral head necrosis in the rabbit and may be a better strategy for the early detection of glucocorticoid-induced femoral head necrosis in patients.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2698540-8
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  • 2
    Online Resource
    Online Resource
    Hindawi Limited ; 2023
    In:  International Journal of RF and Microwave Computer-Aided Engineering Vol. 2023 ( 2023-5-31), p. 1-11
    In: International Journal of RF and Microwave Computer-Aided Engineering, Hindawi Limited, Vol. 2023 ( 2023-5-31), p. 1-11
    Abstract: In order to expand the applications of the traditional Vivaldi antenna by addressing the low gain of the traditional Vivaldi antenna, this paper combines the phase distribution of the Vivaldi antenna aperture based on the analysis of the transmission characteristics of a dielectric unit by utilizing the advantages of artificial electromagnetic material. A more reasonable method of loading a dielectric lens is proposed and utilized in combination with edge grooving. A comparison of the results shows that the antenna operates in the frequency range of 4 to 16 GHz. The low-frequency boost is approximately 3 dB, and the high-frequency boost is approximately 9.6 dB.
    Type of Medium: Online Resource
    ISSN: 1099-047X , 1096-4290
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2007326-4
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  • 3
    In: Advances in Meteorology, Hindawi Limited, Vol. 2016 ( 2016), p. 1-15
    Abstract: We replaced the outdated land-use of the Weather Research and Forecasting-Chemistry (WRF-Chem) model with a refined dataset, the Global Land Cover 2009 (GLC2009) dataset, to investigate the impact of land-use change on the regional atmospheric environment in the Pearl River Delta (PRD) region. Simulations of two months in 2014 (January and July) showed that land-use change increased the monthly averaged 2 m temperature by 0.24°C and 0.27°C in January and July, respectively. The relative humidity decreased by 2.02% and 2.23% in January and July, respectively. Due to the increase in ground roughness, the monthly averaged wind speed in January and July decreased by 0.19 m/s and 0.16 m/s. The planetary boundary layer height increased throughout the day and with larger relative increase during the nighttime. These subtle changes caused by land-use resulted in discernable changes in pollutant concentrations. Monthly averaged surface O 3 concentration increased by 0.93  µ g/m 3 and 1.61  µ g/m 3 in January and July, while PM 2.5 concentration decreased by 1.58  µ g/m 3 and 3.76  µ g/m 3 , and the changes in pollutant concentrations were more noticeable during the nighttime. Overall, the impacts of land-use change on the atmospheric environment are obvious throughout the PRD region, especially in the urbanized areas.
    Type of Medium: Online Resource
    ISSN: 1687-9309 , 1687-9317
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2486777-9
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  • 4
    In: Autoimmune Diseases, Hindawi Limited, Vol. 2016 ( 2016), p. 1-11
    Abstract: Background. Serum concentrations of soluble interleukin-7 receptor (sIL-7R) and anti-C1q antibody have recently been identified as unique serological markers for lupus nephritis (LN) in patients with systemic lupus erythematosus (SLE). In this study, we evaluated the correlation of serum sIL-7R and anti-C1q in SLE patients. Methods. Sera from 134 patients with SLE and 84 healthy cohorts were tested for levels of sIL-7R and anti-C1q antibodies in terms of ELISA. Correlations of the sIL-7R and anti-C1q autoantibodies were evaluated. Results. The serum concentrations of sIL-7R and anti-C1q antibodies were significantly higher in SLE patients and LN patients in comparison with healthy individuals/controls and SLE patients with non-LN, respectively. In addition, both sIL-7R and anti-C1q concentrations were found to significantly correlate with the SLE disease activity as evaluated by SLEDAI scores. Interestingly, the serum sIL-7R concentration was strongly correlated with the level of anti-C1q antibodies ( r = 0.2871 , p = 0.0008 ) but not statistically correlated with other serological markers, including the anti-dsDNA and complements C3 and C4 concentrations in SLE patients. Conclusion. Both serum sIL-7R and anti-C1q antibodies were strongly associated with disease activity and LN in SLE patients, suggesting that they may be reliable serological markers for identification of SLE patients with active diseases and LN.
    Type of Medium: Online Resource
    ISSN: 2090-0422 , 2090-0430
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2573894-X
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  • 5
    Online Resource
    Online Resource
    Hindawi Limited ; 2022
    In:  Computational and Mathematical Methods in Medicine Vol. 2022 ( 2022-8-16), p. 1-7
    In: Computational and Mathematical Methods in Medicine, Hindawi Limited, Vol. 2022 ( 2022-8-16), p. 1-7
    Abstract: Objective. This study investigated the types and significance of mutant genes in children with acute lymphoblastic leukemia (ALL). Methods. The gene sequencing data of 89 ALL children were retrospectively analyzed. Log-rank test was used to analyze the effect of different numbers of mutant genes on the clinical characteristics of the patients and disease. Results. Known gene mutations were detected in 64% (57/89) of the children, including one gene mutation in 31% and two or more gene mutations in 33% of the patients. Gene sequencing showed that most mutations occurred in KRAS (17%), NRAS (15%), FLT3 (7%), TP53 (7%), and PTPN11 (7%), and functional clustering analysis showed that most were signaling pathway genes (50%). In the overall cohort, no association was found between clinical characteristics and gene mutation. The children were then classified into three groups: group A (no gene mutation), group B (one gene mutation), and group C (two or more gene mutations). Correlation analysis showed that group A had significantly more children with medium risk ALL ( P = 0.037 ), and group C had markedly more children with high risk ALL ( P = 0.001 ). Further analysis showed that children with mutant genes took significantly more time to enter the maintenance phase than children without mutations. Conclusion. Children with ALL had a high gene mutation rate, especially in KRAS and NRAS genes, and the mutant genes were mainly signal pathway-related. The gene mutations were significantly correlated with clinical phenotype and the time taken to enter the maintenance phase.
    Type of Medium: Online Resource
    ISSN: 1748-6718 , 1748-670X
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2256917-0
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  • 6
    Online Resource
    Online Resource
    Hindawi Limited ; 2016
    In:  BioMed Research International Vol. 2016 ( 2016), p. 1-7
    In: BioMed Research International, Hindawi Limited, Vol. 2016 ( 2016), p. 1-7
    Abstract: Near-infrared fluorescence (NIRF) imaging technology is a highly sensitive imaging modality and has been widely used in noninvasively studying the status of receptor expression in small animal models, with an appropriate NIRF probe targeting a specific receptor. In this report, Cy5.5-conjugated anti-CAIX monoclonal antibody (Mab-Cy5.5) was evaluated in athymic mice bearing HT-29 tumor xenografts in order to investigate the effect of conjugate on tumor targeting efficacy. In vitro binding studies showed that Mab-Cy5.5 could specifically bind to the cells which expressed CAIX. Results from in vivo imaging showed that HT-29 tumor xenografts can be clearly visualized at 48 h after injection of Mab-Cy5.5, and in the blocking experiment, free anti-CAIX antibody effectively blocked the concentration of Mab-Cy5.5 in the tumors. Western blotting and immunohistochemistry analysis of HT-29 tumor xenografts verified the expression of CAIX in HT-29 tumors. Mab-Cy5.5 could specifically bind to the tumors which expressed CAIX. These results suggested that Mab-Cy5.5 was suitable for CAIX expression imaging in the preclinical research.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2698540-8
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  • 7
    Online Resource
    Online Resource
    Hindawi Limited ; 2017
    In:  Journal of Immunology Research Vol. 2017 ( 2017), p. 1-13
    In: Journal of Immunology Research, Hindawi Limited, Vol. 2017 ( 2017), p. 1-13
    Abstract: An early diagnosis of lupus nephritis (LN) has an important clinical implication in guiding treatments of systemic lupus erythematosus (SLE) in clinical settings. In this study, the concentrations of Wnt-3A, Frizzled-8 (FZD-8), and Dickkopf-1 (DKK-1) of Wnt signaling, as well as their diagnostic values for accessing LN, were evaluated by ELISA in sera and urine of 111 SLE patients (31 with LN and 80 without LN) and 70 healthy cohorts. Significantly more abundances of DKK-1 protein were determined in both of sera and urine of SLE patients compared to healthy cohorts ( p 〈 0.0001 ); in particular the serum DKK-1 concentration was even higher in LN-SLE patients relative to non-LN SLE subjects ( p 〈 0.0001 ). Intriguingly, concentrations of above examined proteins in SLE patients showed no correlation between serum and urine. Moreover, a combination of DKK-1 with anti-dsDNA and/or levels of complement C3 and C4 could not increase the specificity and/or sensitivity for identification of patients with LN diseases, but both ROC curve and multiple-factor nonconditional logistic regression analysis showed that serum DKK-1 was considered better positive biomarker for identification of LN in SLE patients. These results imply that serum and/or urine DKK-1 may be a valuable and independent biomarker for identification of SLE patients with LN.
    Type of Medium: Online Resource
    ISSN: 2314-8861 , 2314-7156
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2817541-4
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