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  • 1
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    Online Resource
    Tetratricopeptide repeat protein SlREC2 positively regulates cold tolerance in tomato
    Oxford University Press (OUP) ; 2023
    In:  Plant Physiology Vol. 192, No. 1 ( 2023-05-02), p. 648-665
    Details
    In: Plant Physiology, Oxford University Press (OUP), Vol. 192, No. 1 ( 2023-05-02), p. 648-665
    Abstract: Cold stress is a key environmental constraint that dramatically affects the growth, productivity, and quality of tomato (Solanum lycopersicum); however, the underlying molecular mechanisms of cold tolerance remain poorly understood. In this study, we identified REDUCED CHLOROPLAST COVERAGE 2 (SlREC2) encoding a tetratricopeptide repeat protein that positively regulates tomato cold tolerance. Disruption of SlREC2 largely reduced abscisic acid (ABA) levels, photoprotection, and the expression of C-REPEAT BINDING FACTOR (CBF)-pathway genes in tomato plants under cold stress. ABA deficiency in the notabilis (not) mutant, which carries a mutation in 9-CIS-EPOXYCAROTENOID DIOXYGENASE 1 (SlNCED1), strongly inhibited the cold tolerance of SlREC2-silenced plants and empty vector control plants and resulted in a similar phenotype. In addition, foliar application of ABA rescued the cold tolerance of SlREC2-silenced plants, which confirms that SlNCED1-mediated ABA accumulation is required for SlREC2-regulated cold tolerance. Strikingly, SlREC2 physically interacted with β-RING CAROTENE HYDROXYLASE 1b (SlBCH1b), a key regulatory enzyme in the xanthophyll cycle. Disruption of SlBCH1b severely impaired photoprotection, ABA accumulation, and CBF-pathway gene expression in tomato plants under cold stress. Taken together, this study reveals that SlREC2 interacts with SlBCH1b to enhance cold tolerance in tomato via integration of SlNCED1-mediated ABA accumulation, photoprotection, and the CBF-pathway, thus providing further genetic knowledge for breeding cold-resistant tomato varieties.
    Type of Medium: Online Resource
    ISSN: 0032-0889 , 1532-2548
    URL: Article
    DOI: 10.1093/plphys/kiad085
    RVK:
    WA 15000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2004346-6
    detail.hit.zdb_id: 208914-2
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  • 2
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    Light quality regulates plant biomass and fruit quality through a photoreceptor-dependent HY5-LHC/CYCB module in tomato
    Oxford University Press (OUP) ; 2023
    In:  Horticulture Research Vol. 10, No. 12 ( 2023-12-05)
    Details
    In: Horticulture Research, Oxford University Press (OUP), Vol. 10, No. 12 ( 2023-12-05)
    Abstract: Increasing photosynthesis and light capture offers possibilities for improving crop yield and provides a sustainable way to meet the increasing global demand for food. However, the poor light transmittance of transparent plastic films and shade avoidance at high planting density seriously reduce photosynthesis and alter fruit quality in vegetable crops, and therefore it is important to investigate the mechanisms of light signaling regulation of photosynthesis and metabolism in tomato (Solanum lycopersicum). Here, a combination of red, blue, and white (R1W1B0.5) light promoted the accumulation of chlorophyll, carotenoid, and anthocyanin, and enhanced photosynthesis and electron transport rates by increasing the density of active reaction centers and the expression of the genes LIGHT-HARVESTING COMPLEX B (SlLHCB) and A (SlLHCA), resulting in increased plant biomass. In addition, R1W1B0.5 light induced carotenoid accumulation and fruit ripening by decreasing the expression of LYCOPENE β-CYCLASE (SlCYCB). Disruption of SlCYCB largely induced fruit lycopene accumulation, and reduced chlorophyll content and photosynthesis in leaves under red, blue, and white light. Molecular studies showed that ELONGATED HYPOCOTYL 5 (SlHY5) directly activated SlCYCB, SlLHCB, and SlLHCA expression to enhance chlorophyll accumulation and photosynthesis. Furthermore, R1W1B0.5 light-induced chlorophyll accumulation, photosynthesis, and SlHY5 expression were largely decreased in the slphyb1cry1 mutant. Collectively, R1W1B0.5 light noticeably promoted photosynthesis, biomass, and fruit quality through the photoreceptor (SlPHYB1 and SlCRY1)-SlHY5-SlLHCA/B/SlCYCB module in tomato. Thus, the manipulation of light environments in protected agriculture is a crucial tool to regulate the two vital agronomic traits related to crop production efficiency and fruit nutritional quality in tomato.
    Type of Medium: Online Resource
    ISSN: 2052-7276
    URL: Article
    DOI: 10.1093/hr/uhad219
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2781828-7
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  • 3
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    Emerging role of exosome signalling in maintaining cancer stem cell dynamic equilibrium
    Wiley ; 2018
    In:  Journal of Cellular and Molecular Medicine Vol. 22, No. 8 ( 2018-08), p. 3719-3728
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 22, No. 8 ( 2018-08), p. 3719-3728
    Abstract: Cancer stem cells ( CSC s) are a small subset of heterogeneous cells existed in tumour tissues or cancer cell lines with self‐renewal and differentiation potentials. CSC s were considered to be responsible for the failure of conventional therapy and tumour recurrence. However, CSC s are not a static cell population, CSC s and non‐ CSC s are maintained in dynamic interconversion state by their self‐differentiation and dedifferentiation. Therefore, targeting CSC s for cancer therapy is still not enough,exploring the mechanism of dynamic interconversion between CSC s and non‐ CSC s and blocking the interconversion seems to be imperative. Exosomes are 30‐100 nm size in diameter extracellular vesicles ( EV s) secreted by multiple living cells into the extracellular space. They contain cell‐state‐specific bioactive materials, including DNA , mRNA , nc RNA , proteins, lipids, etc. with their specific surface markers, such as, CD 63, CD 81, Alix, Tsg101, etc. Exosomes have been considered as information carriers in cell communication between cancer cells and non‐cancer cells, which affect gene expressions and cellular signalling pathways of recipient cells by delivering their contents. Now that exosomes acted as information carriers, whether they played role in maintaining dynamic equilibrium state between CSC s and non‐ CSC s and their mechanism of activity are unknown. This review summarized the current research advance of exosomes’ role in maintaining CSC dynamic interconversion state and their possible mechanism of action, which will provide a better understanding the contribution of exosomes to dedifferentiation and stemness acquisition of non‐ CSC s, and highlight that exosomes might be taken as the attractive target approaches for cancer therapeutics.
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.2018.22.issue-8
    DOI: 10.1111/jcmm.13676
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2076114-4
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  • 4
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    Esculentoside A suppresses breast cancer stem cell growth through stemness attenuation and apoptosis induction by blocking IL‐6/STAT3 signaling pathway
    Wiley ; 2018
    In:  Phytotherapy Research Vol. 32, No. 11 ( 2018-11), p. 2299-2311
    Details
    In: Phytotherapy Research, Wiley, Vol. 32, No. 11 ( 2018-11), p. 2299-2311
    Abstract: Breast cancer stem cells (CSCs) survive in inflammatory microenvironment, their survival are regulated by inflammatory cytokines and signaling pathways. Esculentoside A (EsA), a triterpene saponin derived from the root of Phytolacca esculenta , possesses antiinflammation effects; but whether it has anticancer activity is unknown. The purpose of this study is to test the inhibitory effect of EsA on the growth of breast CSCs and to elucidate its probable mechanisms of action. The proliferation inhibitory effect of EsA on breast CSCs in vitro were determined by cytotoxicity, mammosphere formation inhibition, apoptotic cell detection assays, and in vivo tumor growth inhibition experiment. The possible molecular mechanisms elucidating the inhibitory effect of EsA on breast CSC growth were examined with western blotting. EsA caused proliferation and mammosphere formation inhibition of breast CSCs; induced breast CSCs apoptotic death; suppressed the growth of tumors generated from breast CSCs significantly; the expressions of stemness proteins including ALDH1A1, Sox2, and Oct4 were downregulated; proapoptotic proteins, Bax and cleaved caspase‐3 were upregulated, whereas the antiapoptotic protein Bcl‐2 was reduced; IL‐6/STAT3 pathway proteins including IL‐6, phosphorylated STAT3 (Tyr705), and STAT3 (Ser727) were downregulated significantly in EsA‐treated breast CSCs and tumor tissues. EsA inhibited breast CSC growth in vitro and in vivo through stemness attenuation and apoptosis induction by blocking IL‐6/STAT3 signaling pathway; it might serve as a novel candidate agent for human breast cancer treatment and/or prevention.
    Type of Medium: Online Resource
    ISSN: 0951-418X , 1099-1573
    URL: Issue
    URL: Article
    DOI: 10.1002/ptr.v32.11
    DOI: 10.1002/ptr.6172
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1493490-5
    SSG: 15,3
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  • 5
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    Effects and plasma proteomic analysis of GLP-1RA versus CPA/EE, in combination with metformin, on overweight PCOS women: a randomized controlled trial
    Springer Science and Business Media LLC ; 2023
    In:  Endocrine
    Details
    In: Endocrine, Springer Science and Business Media LLC
    Abstract: Polycystic ovary syndrome (PCOS) is characterized by reproductive dysfunctions and metabolic disorders. This study aims to compare the therapeutic effectiveness of glucagon-like peptide-1 receptor agonist (GLP-1RA) + Metformin (Met) versus cyproterone acetate/ethinylestradiol (CPA/EE) + Met in overweight PCOS women and identify potential proteomic biomarkers of disease risk in women with PCOS. Methods In this prospective, open-label randomized controlled trial, we recruited 60 overweight PCOS women into two groups at a 1:1 ratio to receive CPA/EE (2 mg/day: 2 mg cyproterone acetate and 35-μg ethinylestradiol,) +Met (1500 mg/day) or GLP-1 RA (liraglutide, 1.2–1.8 mg/day) +Met (1500 mg/day) for 12 weeks. The clinical effectiveness and adverse effects were evaluated, followed by plasma proteomic analysis and verification of critical biomarkers by ELISA. Results Eighty(80%) patients completed the study. Both interventions improved menstrual cycle, polycystic ovaries, LH(luteinizing hormone) and HbA1c(hemoglobin A1c) levels after the 12-week treatment. GLP-1RA + Met was more effective than CPA/EE + Met in reducing body weight, BMI (Body Mass Index), and waist circumference, FBG(fasting blood glucose), AUCI(area under curve of insulin),TC (Total Cholesterol), IL-6(Interleukin-6) and improving insulin sensitivity, and ovulation in overweight women with PCOS, with acceptable short-term side effects. CPA/EE + Met was more effective in improving hyperandrogenemia, including T(total testosterone), LH, LH/FSH(Luteinizing hormone/follicle-stimulating hormone), SHBG(sex hormone-binding globulin) and FAI (free androgen index). By contract, GLP-1RA+Met group only improved LH. Plasma proteomic analysis revealed that the interventions altered proteins involved in reactive oxygen species detoxification (PRDX6, GSTO1, GSTP1, GSTM2), platelet degranulation (FN1), and the immune response (SERPINB9). Conclusions Both CPA/EE+Met and GLP-1RA + Met treatment improved reproductive functions in overweight PCOS women. GLP-1RA + Met was more effective than CPA/EE + Met in reducing body weight, BMI, and waist, and improving metabolism, and ovulation in overweight women with PCOS, with acceptable short-term side effects. CPA/EE + Met was more effective in reducing hyperandrogenemia. The novel plasma biomarkers PRDX6, FN1, and SERPINB9, might be indicators and targets for PCOS treatment. Trial registration ClinicalTials.gov Trial No: NCT03151005. Registered 12 May, 2017, https://clinicaltrials.gov/ct2/show/NCT03151005 .
    Type of Medium: Online Resource
    ISSN: 1559-0100
    URL: Article
    DOI: 10.1007/s12020-023-03487-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2074043-8
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  • 6
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    Invasive Pituitary Adenoma-Derived Tumor-Associated Fibroblasts Promote Tumor Progression both In Vitro and In Vivo
    Georg Thieme Verlag KG ; 2018
    In:  Experimental and Clinical Endocrinology & Diabetes Vol. 126, No. 04 ( 2018-04), p. 213-221
    Details
    In: Experimental and Clinical Endocrinology & Diabetes, Georg Thieme Verlag KG, Vol. 126, No. 04 ( 2018-04), p. 213-221
    Abstract: Tumor-associated fibroblasts are the most abundant population in tumor stroma and impact on tumor initiation and progression. However, the biological function of tumor-associated fibroblasts in pituitary adenomas has not been fully elucidated to date. So, this study aims to clarify the function and significance of primary cultured pituitary adenoma-derived tumor-associated fibroblasts on rat pituitary adenoma cells. We identified primary cultured tumor-associated fibroblasts and normal fibroblasts based on the expression of α-smooth muscle actin as well as morphology. Furthermore, we investigated cell biological influences on rat pituitary adenoma cells through indirectly co-culturing tumor-associated fibroblasts with GH3 cells and subcutaneous xenograft model. All sorts of fibroblasts showed positive staining for α-smooth muscle actin. But α-smooth muscle actin and vascular endothelial growth factor highly expressed in invasive pituitary adenoma-derived tumor-associated fibroblasts compared to non-invasive pituitary adenoma-derived tumor-associated fibroblasts and normal fibroblasts. Besides, invasive pituitary adenoma-derived tumor-associated fibroblasts promoted the proliferation of GH3 cells in vitro as well as tumor growth in vivo. Finally, vascular endothelial growth factor was highly expressed in tumor specimens co-injected with invasive pituitary adenoma-derived tumor-associated fibroblasts. Our results suggested that invasive pituitary adenoma-derived tumor-associated fibroblasts displayed apparent growth promotion effects on rat pituitary cells both in vitro and in vivo accompanied by over-expression of vascular endothelial growth factor in invasive pituitary adenoma-derived tumor-associated fibroblasts and tumor specimens.
    Type of Medium: Online Resource
    ISSN: 0947-7349 , 1439-3646
    URL: Article
    DOI: 10.1055/s-0043-119636
    RVK:
    XA 42403
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2018
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  • 7
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    Optimization of nitrogen and carbon removal with simultaneous partial nitrification, anammox and denitrification in membrane bioreactor
    The Royal Society ; 2020
    In:  Royal Society Open Science Vol. 7, No. 9 ( 2020-09), p. 200584-
    Details
    In: Royal Society Open Science, The Royal Society, Vol. 7, No. 9 ( 2020-09), p. 200584-
    Abstract: In this study, a membrane bioreactor (MBR) was used to achieve both nitrogen and carbon removal by a simultaneous partial nitrification, anammox and denitrification (SNAD) process. During the entire experiment, the intermittent aeration (non-aerobic time : aeration time, min min −1 ) cycle was controlled by a time-controlled switch, and the aeration rate was controlled by a gas flowmeter, and the optimal operating parameters as determined by response surface methodology (RSM) were a C/N value of 1.16, a DO value of 0.84 mg l −1 and an aerobic time ( T ae ) of 15.75 min. Under these conditions, the SNAD process achieved efficient and stable nitrogen and carbon removal; the total inorganic nitrogen removal efficiency and chemical oxygen demand removal efficiency were 92.31% and 95.67%, respectively. With the formation of granular sludge, the membrane fouling rate decreased significantly from 35.0 Pa h −1 at SNAD start-up to 19.9 Pa h −1 during stable operation. Fluorescence in situ hybrid analyses confirmed the structural characteristics and the relative ratio of aerobic ammonia-oxidizing bacteria, anaerobic ammonia-oxidizing bacteria and denitrifying bacteria in the SNAD system.
    Type of Medium: Online Resource
    ISSN: 2054-5703
    URL: Article
    DOI: 10.1098/rsos.200584
    Language: English
    Publisher: The Royal Society
    Publication Date: 2020
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  • 8
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    Morusin shows potent antitumor activity for human hepatocellular carcinoma in vitro and in vivo through apoptosis induction and angiogenesis inhibition
    Informa UK Limited ; 2017
    In:  Drug Design, Development and Therapy Vol. Volume 11 ( 2017-06), p. 1789-1802
    Details
    In: Drug Design, Development and Therapy, Informa UK Limited, Vol. Volume 11 ( 2017-06), p. 1789-1802
    Type of Medium: Online Resource
    ISSN: 1177-8881
    URL: Journal
    URL: Article
    DOI: 10.2147/DDDT
    DOI: 10.2147/DDDT.S138320
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2451346-5
    SSG: 15,3
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  • 9
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    Simultaneous nitrification and denitrification by a novel isolated Pseudomonas sp. JQ-H3 using polycaprolactone as carbon source
    Elsevier BV ; 2019
    In:  Bioresource Technology Vol. 288 ( 2019-09), p. 121506-
    Details
    In: Bioresource Technology, Elsevier BV, Vol. 288 ( 2019-09), p. 121506-
    Type of Medium: Online Resource
    ISSN: 0960-8524
    URL: Article
    DOI: 10.1016/j.biortech.2019.121506
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2019
    detail.hit.zdb_id: 1501389-3
    SSG: 12
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  • 10
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    SlFHY3 and SlHY5 act compliantly to enhance cold tolerance through the integration of myo ‐inositol and light signaling in tomato
    Wiley ; 2022
    In:  New Phytologist Vol. 233, No. 5 ( 2022-03), p. 2127-2143
    Details
    In: New Phytologist, Wiley, Vol. 233, No. 5 ( 2022-03), p. 2127-2143
    Abstract: Plants have evolved sophisticated regulatory networks to cope with dynamically changing light and temperature environments during day–night and seasonal cycles. However, the integration mechanisms of light and low temperature remain largely unclear. Here, we show that low red : far‐red ratio (LR : FR) induces FAR‐RED ELONGATED HYPOCOTYL3 ( SlFHY3 ) transcription under cold stress in tomato ( Solanum lycopersicum ). Reverse genetic approaches revealed that knocking out SlFHY3 decreases myo ‐inositol accumulation and increases cold susceptibility, whereas overexpressing SlFHY3 induces myo ‐inositol accumulation and enhances cold tolerance in tomato plants. SlFHY3 physically interacts with ELONGATED HYPOCOTYL5 (SlHY5) to promote the transcriptional activity of SlHY5 on MYO‐INOSITOL‐1‐PHOSPHATE SYNTHASE 3 ( SlMIPS3 ) and induce myo ‐inositol accumulation in tomato plants under cold stress. Disruption of SlHY5 and SlMIPS3 largely suppresses the cold tolerance of SlFHY3 ‐overexpressing plants and myo ‐inositol accumulation in tomato. Furthermore, silencing of SlMIPS3 drastically reduces myo ‐inositol accumulation and compromises LR : FR‐induced cold tolerance in tomato. Together, our results reveal a crucial role of SlFHY3 in LR : FR‐induced cold tolerance in tomato and unravel a novel regulatory mechanism whereby plants integrate dynamic environmental light signals and internal cues (inositol biosynthesis) to induce and control cold tolerance in tomato plants.
    Type of Medium: Online Resource
    ISSN: 0028-646X , 1469-8137
    URL: Issue
    URL: Article
    DOI: 10.1111/nph.v233.5
    DOI: 10.1111/nph.17934
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 208885-X
    detail.hit.zdb_id: 1472194-6
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