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  • Wiley  (114)
  • Wang, Xin  (114)
  • 1
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    A randomized, double‐blind, placebo‐controlled phase 1 and phase 2 clinical trial to evaluate efficacy and safety of a SARS‐CoV‐2 vaccine SCoK in adults
    Wiley ; 2022
    In:  Clinical and Translational Medicine Vol. 12, No. 9 ( 2022-09)
    Details
    In: Clinical and Translational Medicine, Wiley, Vol. 12, No. 9 ( 2022-09)
    Abstract: To determine an appropriate dose of, and immunization schedule for, a vaccine SCoK against COVID‐19 for an efficacy study; herein, we conducted randomized controlled trials to assess the immunogenicity and safety of this vaccine in adults. Methods These randomized, double‐blind, placebo‐controlled phase 1 and 2 trials of vaccine SCoK were conducted in Binhai District, Yan City, Jiangsu Province, China. Younger and older adult participants in phase 1 and 2 trials were sequentially recruited into different groups to be intramuscularly administered 20 or 40 μg vaccine SCoK or placebo. Participants were enrolled into our phase 1 and 2 studies to receive vaccine or placebo. Results No serious vaccine‐related adverse events were observed in either trial. In both trials, local and systemic adverse reactions were absent or mild in most participants. In our phase 1 and 2 studies, the vaccine induced significantly increased neutralizing antibody responses to pseudovirus and live SARS‐CoV‐2. The vaccine induced significant neutralizing antibody responses to live SARS‐CoV‐2 on day 14 after the last immunization, with NT50s of 80.45 and 92.46 in participants receiving 20 and 40 μg doses, respectively; the seroconversion rates were 95.83% and 100%. The vaccine SCoK showed a similar safety and immunogenicity profiles in both younger participants and older participants. The vaccine showed better immunogenicity in phase 2 than in phase 1 clinical trial. Additionally, the incidence of adverse reactions decreased significantly in phase 2 clinical trial. The vaccine SCoK was well tolerated and immunogenic.
    Type of Medium: Online Resource
    ISSN: 2001-1326 , 2001-1326
    URL: Issue
    URL: Article
    DOI: 10.1002/ctm2.v12.9
    DOI: 10.1002/ctm2.1016
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2697013-2
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  • 2
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    Dual Integrating Oxygen and Sulphur on Surface of CoTe Nanorods Triggers Enhanced Oxygen Evolution Reaction
    Wiley ; 2023
    In:  Advanced Science Vol. 10, No. 9 ( 2023-03)
    Details
    In: Advanced Science, Wiley, Vol. 10, No. 9 ( 2023-03)
    Abstract: The bottleneck of large‐scale implementation of electrocatalytic water‐splitting technology lies in lacking inexpensive, efficient, and durable catalysts to accelerate the sluggish oxygen evolution reaction kinetics. Owing to more metallic features, transition metal telluride (TMT) with good electronic conductivity holds promising potential as an ideal type of electrocatalysts for oxygen evolution reaction (OER), whereas most TMTs reported up to now still show unsatisfactory OER performance that is far below corresponding sulfide and selenide counterparts. Here, the activation and stabilization of cobalt telluride (CoTe) nanoarrays toward OER through dual integration of sulfur (S) doping and surface oxidization is reported. The as‐synthesized CoO@S‐CoTe catalyst exhibits a low overpotential of only 246 mV at 10 mA cm −2 and a long‐term stability of more than 36 h, outperforming commercial RuO 2 and other reported telluride‐based OER catalysts. The combined experimental and theoretical results reveal that the enhanced OER performance stems from increased active sites exposure, improved charge transfer ability, and optimized electronic state. This work will provide a valuable guidance to release the catalytic potential of telluride‐based OER catalysts via interface modulating engineering.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v10.9
    DOI: 10.1002/advs.202206204
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2808093-2
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  • 3
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    Development and validation of an immune‐related prognostic signature in lung adenocarcinoma
    Wiley ; 2020
    In:  Cancer Medicine Vol. 9, No. 16 ( 2020-08), p. 5960-5975
    Details
    In: Cancer Medicine, Wiley, Vol. 9, No. 16 ( 2020-08), p. 5960-5975
    Abstract: Lung adenocarcinomas (LUAD) is the most common histological subtype of lung cancers. Tumor immune microenvironment (TIME) is involved in tumorigeneses, progressions, and metastases. This study is aimed to develop a robust immune‐related signature of LUAD. Methods A total of 1774 LUAD cases sourced from public databases were included in this study. Immune scores were calculated through ESTIMATE algorithm and weighted gene co‐expression network analysis (WGCNA) was applied to identify immune‐related genes. Stability selections and Lasso COX regressions were implemented to construct prognostic signatures. Validations and comparisons with other immune‐related signatures were conducted in independent Gene Expression Omnibus (GEO) cohorts. Abundant infiltrated immune cells and pathway enrichment analyses were carried out, respectively, through ImmuCellAI and gene set enrichment analysis (GSEA). Results In Cancer Genome Atlas (TCGA) LUAD cohorts, immune scores of higher levels were significantly associated with better prognoses ( P   〈  .05). Yellow (n = 270) and Blue (n = 764) colored genes were selected as immune‐related genes, and after univariate Cox regression analysis ( P   〈  .005), a total of 133 genes were screened out for subsequent model constructions. A four‐gene signature (ARNTL2, ECT2, PPIA, and TUBA4A) named IPSLUAD was developed through stability selection and Lasso COX regression. It was suggested by multivariate and subgroup analyses that IPSLUAD was an independent prognostic factor. It was suggested by Kaplan‐Meier survival analysis that eight out of nine patients in high‐risk groups had significantly worse prognoses in validation data sets ( P   〈  .05). IPSLUAD outperformed other signatures in two independent cohorts. Conclusions A robust immune‐related prognostic signature with great performances in multiple LUAD cohorts was developed in this study.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.v9.16
    DOI: 10.1002/cam4.3240
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2659751-2
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  • 4
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    ChemInform Abstract: Asymmetric Synthesis and Biological Evaluation of N-Cyclohexyl-4- [1-(2,4-dichlorophenyl)-1-(p-tolyl)methyl]piperazine-1-carboxamide as hCB1 Receptor Antagonists.
    Wiley ; 2012
    In:  ChemInform Vol. 43, No. 11 ( 2012-03-13), p. no-no
    Details
    In: ChemInform, Wiley, Vol. 43, No. 11 ( 2012-03-13), p. no-no
    Type of Medium: Online Resource
    ISSN: 0931-7597
    URL: Article
    DOI: 10.1002/chin.201211153
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 2110203-X
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  • 5
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    Basiliximab for steroid‐refractory acute graft‐versus‐host disease: A real‐world analysis
    Wiley ; 2022
    In:  American Journal of Hematology Vol. 97, No. 4 ( 2022-04), p. 458-469
    Details
    In: American Journal of Hematology, Wiley, Vol. 97, No. 4 ( 2022-04), p. 458-469
    Abstract: Steroid‐refractory (SR) acute graft‐versus‐host disease (aGVHD) is one of the leading causes of early mortality after allogeneic hematopoietic stem cell transplantation (allo‐HSCT). We investigated the efficacy, safety, prognostic factors, and optimal therapeutic protocol for SR‐aGVHD patients treated with basiliximab in a real‐world setting. Nine hundred and forty SR‐aGVHD patients were recruited from 36 hospitals in China, and 3683 doses of basiliximab were administered. Basiliximab was used as monotherapy ( n  = 642) or in combination with other second‐line treatments ( n  = 298). The cumulative incidence of overall response rate (ORR) at day 28 after basiliximab treatment was 79.4% (95% confidence interval [CI] 76.5%–82.3%). The probabilities of nonrelapse mortality and overall survival at 3 years after basiliximab treatment were 26.8% (95% CI 24.0%–29.6%) and 64.3% (95% CI 61.2%–67.4%), respectively. A 1:1 propensity score matching was performed to compare the efficacy and safety between the monotherapy and combined therapy groups. Combined therapy did not increase the ORR; conversely, it increased the infection rates compared with monotherapy. The multivariate analysis showed that combined therapy, grade III–IV aGVHD, and high‐risk refined Minnesota aGVHD risk score before basiliximab treatment were independently associated with the therapeutic response. Hence, we created a prognostic scoring system that could predict the risk of having a decreased likelihood of response after basiliximab treatment. Machine learning was used to develop a protocol that maximized the efficacy of basiliximab while maintaining acceptable levels of infection risk. Thus, real‐world data suggest that basiliximab is safe and effective for treating SR‐aGVHD.
    Type of Medium: Online Resource
    ISSN: 0361-8609 , 1096-8652
    URL: Issue
    URL: Article
    DOI: 10.1002/ajh.v97.4
    DOI: 10.1002/ajh.26475
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1492749-4
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  • 6
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    Rice miR5504 regulates plant height by affecting cell proliferation and expansion
    Wiley ; 2023
    In:  Physiologia Plantarum Vol. 175, No. 5 ( 2023-08)
    Details
    In: Physiologia Plantarum, Wiley, Vol. 175, No. 5 ( 2023-08)
    Abstract: miRNAs play critical roles in the regulation of plant growth and development by cleaving mRNA or repressing transcription. In our previous study, miR5504 with unknown functions was captured by small RNA sequencing. Here, the function and characters of miR5504 were extensively analyzed using CRISPR/Cas9, overexpression strategy, Northern blot, cytological analysis, and transcriptomics analysis. We found that the dwarf phenotype of mir5504 mutants ( mir5504‐1 and mir5504‐2 ) appeared on 35‐day seedlings and became more apparent at the mature stage. The cytological results showed a substantial decrease in the vascular bundle number, cell number and cell length in the mir5504 mutant compared with NIP. In addition, we found that miR5504 regulated plant height by targeting LOC_Os08g16914. The results of RNA‐seq revealed that numerous biological processes were mainly enriched, including DNA‐binding transcription factor activity, transferase activity, regulation of transcription, metabolic process, and protein binding. Meanwhile, KEEG analysis showed that numerous proteins were associated with cellular processes and metabolism pathways. Taken together, miR5504 may be involved in the regulation of plant height by affecting cell expansion and division of internode in rice.
    Type of Medium: Online Resource
    ISSN: 0031-9317 , 1399-3054
    URL: Issue
    URL: Article
    DOI: 10.1111/ppl.v175.5
    DOI: 10.1111/ppl.14023
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 208872-1
    detail.hit.zdb_id: 2020837-6
    SSG: 12
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  • 7
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    A 64 Cu‐porphyrin‐based dual‐modal molecular probe with integrin α v β 3 targeting function for tumour imaging
    Wiley ; 2020
    In:  Journal of Labelled Compounds and Radiopharmaceuticals Vol. 63, No. 5 ( 2020-05-15), p. 212-221
    Details
    In: Journal of Labelled Compounds and Radiopharmaceuticals, Wiley, Vol. 63, No. 5 ( 2020-05-15), p. 212-221
    Abstract: Pyropheophorbide‐a (Pyro) is a promising multifunctional molecule for multimodal tumour imaging and photodynamic therapy, but its clinical applications are seriously restricted by the limited tumour accumulation capability. Here, we designed and synthesized a small‐molecule probe that achieved specific dual‐modal tumour imaging based on Pyro. Briefly, a novel molecule combining Pyro, an RGD dimer peptide (3PRGD 2 ) and 64 Cu, was designed and synthesized, and the obtained molecule, 64 Cu‐Pyro‐3PRGD 2 , exhibited high tumour specificity in both positron emission tomography and optical imaging in vivo. c (RGDfk) peptide blocking significantly reduced the efficacy of the probe, which confirmed the integrin α V β 3 targeting of this molecular probe. 64 Cu‐Pyro‐3PRGD 2 had very low accumulation in normal organs and could be rapidly cleared through kidney metabolism, which prevented the potential damage to adjacent normal tissues. Overall, combining tumour targeting, dual‐modal imaging, and biosafety, 64 Cu‐Pyro‐3PRGD 2 has the potential for clinical use as a molecular imaging probe for tumour diagnosis.
    Type of Medium: Online Resource
    ISSN: 0362-4803 , 1099-1344
    URL: Issue
    URL: Article
    DOI: 10.1002/jlcr.v63.5
    DOI: 10.1002/jlcr.3833
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1491841-9
    SSG: 15,3
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  • 8
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    Binding of fluphenazine with human serum albumin in the presence of rutin and quercetin: An evaluation of food‐drug interaction by spectroscopic techniques
    Wiley ; 2017
    In:  Luminescence Vol. 32, No. 6 ( 2017-09), p. 1056-1065
    Details
    In: Luminescence, Wiley, Vol. 32, No. 6 ( 2017-09), p. 1056-1065
    Abstract: The interactions between human serum albumin (HSA) and fluphenazine (FPZ) in the presence or absence of rutin or quercetin were studied by fluorescence, absorption and circular dichroism (CD) spectroscopy and molecular modeling. The results showed that the fluorescence quenching mechanism was static quenching by the formation of an HSA–FPZ complex. Entropy change (Δ S 0 ) and enthalpy change (Δ H 0 ) values were 68.42 J/(mol ⋅ K) and −4.637 kJ/mol, respectively, which indicated that hydrophobic interactions and hydrogen bonds played major roles in the acting forces. The interaction process was spontaneous because the Gibbs free energy change (Δ G 0 ) values were negative. The results of competitive experiments demonstrated that FPZ was mainly located within HSA site I (sub‐domain IIA). Molecular docking results were in agreement with the experimental conclusions of the thermodynamic parameters and competition experiments. Competitive binding to HSA between flavonoids and FPZ decreased the association constants and increased the binding distances of FPZ binding to HSA. The results of absorption, synchronous fluorescence, three‐dimensional fluorescence, and CD spectra showed that the binding of FPZ to HSA caused conformational changes in HSA and simultaneous effects of FPZ and flavonoids induced further HSA conformational changes.
    Type of Medium: Online Resource
    ISSN: 1522-7235 , 1522-7243
    URL: Issue
    URL: Article
    DOI: 10.1002/bio.v32.6
    DOI: 10.1002/bio.3291
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2001819-8
    SSG: 12
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  • 9
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    Medial septum tau accumulation induces spatial memory deficit via disrupting medial septum–hippocampus cholinergic pathway
    Wiley ; 2021
    In:  Clinical and Translational Medicine Vol. 11, No. 6 ( 2021-06)
    Details
    In: Clinical and Translational Medicine, Wiley, Vol. 11, No. 6 ( 2021-06)
    Abstract: Tau accumulation and cholinergic impairment are characteristic pathologies in Alzheimer's disease (AD). However, the causal role of tau accumulation in cholinergic lesion is elusive. Here, we observed an aberrant tau accumulation in the medial septum (MS) of 3xTg and 5xFAD mice, especially in their cholinergic neurons. Overexpressing hTau in mouse MS (MS hTau ) for 6 months but not 3 months induced spatial memory impairment without changing object recognition and anxiety‐like behavior, indicating a specific and time‐dependent effect of MS‐hTau accumulation on spatial cognitive functions. With increasing hTau accumulation, the MS hTau mice showed a time‐dependent cholinergic neuron loss with reduced cholinergic projections to the hippocampus. Intraperitoneal administration of donepezil, a cholinesterase inhibitor, for 1 month ameliorated the MS‐hTau‐induced spatial memory deficits with preservation of MS–hippocampal cholinergic pathway and removal of tau load; and the beneficial effects of donepezil was more prominent at low dose. Proteomics revealed that MS‐hTau accumulation deregulated multiple signaling pathways with numerous differentially expressed proteins (DEPs). Among them, the vacuolar protein sorting‐associated protein 37D (VP37D), an autophagy‐related protein, was significantly reduced in MS hTau mice; the reduction of VP37D was restored by donepezil, and the effect was more significant at low dose than high dose. These novel evidences reveal a causal role of tau accumulation in linking MS cholinergic lesion to hippocampus‐dependent spatial cognitive damages as seen in the AD patients, and the new tau‐removal and autophagy‐promoting effects of donepezil may extend its application beyond simple symptom amelioration to potential disease modification.
    Type of Medium: Online Resource
    ISSN: 2001-1326 , 2001-1326
    URL: Issue
    URL: Article
    DOI: 10.1002/ctm2.v11.6
    DOI: 10.1002/ctm2.428
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2697013-2
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  • 10
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    Perineal defect reconstruction after surgery for advanced or locally recurrent rectal cancer involving organ resection: Multiple flaps combined with lining repair
    Wiley ; 2023
    In:  Colorectal Disease
    Details
    In: Colorectal Disease, Wiley
    Abstract: The aim of this study was to investigate the efficacy of multiple perineal perforator flaps in repairing deep perineal defects after pelvic exenteration for locally advanced or recurrent rectal cancer. Method We investigated the outcomes of eight patients whose repairs involved a novel method of using an internal pudendal artery perforator (IPAP) flap combined with an inferior gluteal artery perforator (IGAP) flap. Results There were four male and four female patients with a mean age of 56 years (36–72 years). Bilateral IPAP flaps combined with bilateral IGAP flaps were used in five patients, unilateral IPAP flaps combined with bilateral IGAP flaps were used in two patients and bilateral IPAP flaps were used in one patient. There were no functional limitations in daily activities during the 6‐month follow‐up period. Conclusion Our study showed that using multiple perineal perforator flaps combined with lining repair is feasible for repairing deep perineal defects in patients who have undergone rectal cancer surgery that includes pelvic exenteration.
    Type of Medium: Online Resource
    ISSN: 1462-8910 , 1463-1318
    URL: Article
    DOI: 10.1111/codi.16710
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2004820-8
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