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  • Hindawi Limited  (6)
  • Wang, Tian  (6)
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  • Hindawi Limited  (6)
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  • 1
    Online Resource
    Online Resource
    The Role of P-Glycoprotein in Transport of Danshensu across the Blood-Brain Barrier
    Hindawi Limited ; 2011
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2011 ( 2011), p. 1-5
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2011 ( 2011), p. 1-5
    Abstract: Danshensu (3-(3, 4-dihydroxyphenyl) lactic acid), a water-soluble active component isolated from the root of Salvia miltiorrhiza Bunge, is widely used for the treatment of cerebrovascular diseases. The present study aims to investigate the role of P-glycoprotein in transport of Danshensu across the blood-brain barrier. Sprague-Dawley rats were pretreated with verapamil at a dose of 20 mg kg −1 (verapamil group) or the same volume of normal saline (control group). Ninety minutes later, the animals were administrated with Danshensu (15 mg kg −1 ) by intravenous injection. At 15 min, 30 min, and 60 min after Danshensu administration, the levels of Danshensu in the blood and brain were detected by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). The results showed that Danshensu concentrations in the brain of the rats pretreated with verapamil were significantly increased. In addition, the brain-plasma ratios of the group pretreated with verapamil were much higher than that of the control group. There was no difference in Danshensu level in plasma between the verapamil group and control group. The findings indicated that Danshensu can pass the blood-brain barrier, and P-glycoprotein plays an important role in Danshensu transportation in brain.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2011/713523
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2011
    detail.hit.zdb_id: 2148302-4
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  • 2
    Online Resource
    Online Resource
    Quality Utilization Aware Based Data Gathering for Vehicular Communication Networks
    Hindawi Limited ; 2018
    In:  Wireless Communications and Mobile Computing Vol. 2018 ( 2018), p. 1-25
    Details
    In: Wireless Communications and Mobile Computing, Hindawi Limited, Vol. 2018 ( 2018), p. 1-25
    Abstract: The vehicular communication networks, which can employ mobile, intelligent sensing devices with participatory sensing to gather data, could be an efficient and economical way to build various applications based on big data. However, high quality data gathering for vehicular communication networks which is urgently needed faces a lot of challenges. So, in this paper, a fine-grained data collection framework is proposed to cope with these new challenges. Different from classical data gathering which concentrates on how to collect enough data to satisfy the requirements of applications, a Quality Utilization Aware Data Gathering (QUADG) scheme is proposed for vehicular communication networks to collect the most appropriate data and to best satisfy the multidimensional requirements (mainly including data gathering quantity, quality, and cost) of application. In QUADG scheme, the data sensing is fine-grained in which the data gathering time and data gathering area are divided into very fine granularity. A metric named “Quality Utilization” (QU) is to quantify the ratio of quality of the collected sensing data to the cost of the system. Three data collection algorithms are proposed. The first algorithm is to ensure that the application which has obtained the specified quantity of sensing data can minimize the cost and maximize data quality by maximizing QU. The second algorithm is to ensure that the application which has obtained two requests of application (the quantity and quality of data collection, or the quantity and cost of data collection) could maximize the QU. The third algorithm is to ensure that the application which aims to satisfy the requirements of quantity, quality, and cost of collected data simultaneously could maximize the QU. Finally, we compare our proposed scheme with the existing schemes via extensive simulations which well justify the effectiveness of our scheme.
    Type of Medium: Online Resource
    ISSN: 1530-8669 , 1530-8677
    URL: Article
    DOI: 10.1155/2018/6353714
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2045240-8
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  • 3
    Online Resource
    Online Resource
    Adaptive Transmission Range Based Topology Control Scheme for Fast and Reliable Data Collection
    Hindawi Limited ; 2018
    In:  Wireless Communications and Mobile Computing Vol. 2018 ( 2018-07-12), p. 1-21
    Details
    In: Wireless Communications and Mobile Computing, Hindawi Limited, Vol. 2018 ( 2018-07-12), p. 1-21
    Abstract: An Adaptive Transmission Range Based Topology Control (ATRTC) scheme is proposed to reduce delay and improve reliability for data collection in delay and loss sensitive wireless sensor network. The core idea of the ATRTC scheme is to extend the transmission range to speed up data collection and improve the reliability of data collection. The main innovations of our work are as follows: ( 1 ) an adaptive transmission range adjustment method is proposed to improve data collection reliability and reduce data collection delay. The expansion of the transmission range will allow the data packet to be received by more receivers, thus improving the reliability of data transmission. On the other hand, by extending the transmission range, data packets can be transmitted to the sink with fewer hops. Thereby the delay of data collection is reduced and the reliability of data transmission is improved. Extending the transmission range will consume more energy. Fortunately, we found the imbalanced energy consumption of the network. There is a large amount of energy remains when the network died. ATRTC scheme proposed in this paper can make full use of the residual energy to extend the transmission range of nodes. Because of the expansion of transmission range, nodes in the network form multiple paths for data collection to the sink node. Therefore, the volume of data received and sent by the near-sink nodes is reduced, the energy consumption of the near-sink nodes is reduced, and the network lifetime is increased as well. ( 2 ) According to the analysis in this paper, compared with the CTPR scheme, the ATRTC scheme reduces the maximum energy consumption by 9%, increases the network lifetime by 10%, increases the data collection reliability by 7.3%, and reduces the network data collection time by 23%.
    Type of Medium: Online Resource
    ISSN: 1530-8669 , 1530-8677
    URL: Article
    DOI: 10.1155/2018/4172049
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2045240-8
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  • 4
    Online Resource
    Online Resource
    An Aggregate Signature Based Trust Routing for Data Gathering in Sensor Networks
    Hindawi Limited ; 2018
    In:  Security and Communication Networks Vol. 2018 ( 2018), p. 1-30
    Details
    In: Security and Communication Networks, Hindawi Limited, Vol. 2018 ( 2018), p. 1-30
    Abstract: An Aggregate Signature based Trust Routing (ASTR) scheme is proposed to guarantee safe data collection in WSNs. In ASTR scheme, firstly, the aggregate signature approach is used to aggregate data and keep data integrity. What is more important, a light aggregate signature based detour routing scheme is proposed to send abstract information which includes the data sending time and ID of data, nodes’ ID to the sink over different paths which can verify whether the data reaches the sink safely. In addition, the trust of a path is evaluated according to the success rate of the path. The trust of paths susceptible to frequent attack will be lowered and the path with high trust will be selected for data routing to avoid data gathering through low trust path and thereby increase the success rate of data gathering. Our comprehensive performance analysis has shown that, the ASTR scheme is able to effectively ensure an increase in success rate of data transmission by 23.23%, reduce the data amount loaded by the node by 53.59%, reduce the redundant data by 41.70%.
    Type of Medium: Online Resource
    ISSN: 1939-0114 , 1939-0122
    URL: Article
    DOI: 10.1155/2018/6328504
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2415104-X
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  • 5
    Online Resource
    Online Resource
    A Time and Location Correlation Incentive Scheme for Deep Data Gathering in Crowdsourcing Networks
    Hindawi Limited ; 2018
    In:  Wireless Communications and Mobile Computing Vol. 2018 ( 2018), p. 1-22
    Details
    In: Wireless Communications and Mobile Computing, Hindawi Limited, Vol. 2018 ( 2018), p. 1-22
    Abstract: To tackle the issue in deep crowd sensing, a Time and Location Correlation Incentive (TLCI) scheme is proposed for deep data gathering in crowdsourcing networks. In TLCI scheme, a metric named “Quality of Information Satisfaction Degree” (QoISD) is to quantify how much collected sensing data can satisfy the application’s QoI requirements mainly in terms of data quantity and data coverage. Two incentive algorithms are proposed to satisfy QoISD with different view. The first algorithm is to ensure that the application gets the specified sensing data to maximize the QoISD. Thus, in the first incentive algorithm, the reward for data sensing is to maximize the QoISD. The second algorithm is to minimize the cost of the system while meeting the sensing data requirement and maximizing the QoISD. Thus, in the second incentive algorithm, the reward for data sensing is to maximize the QoISD per unit of reward. Finally, we compare our proposed scheme with existing schemes via extensive simulations. Extensive simulation results well justify the effectiveness of our scheme. The QoISD can be optimized by 81.92%, and the total cost can be reduced by 31.38%.
    Type of Medium: Online Resource
    ISSN: 1530-8669 , 1530-8677
    URL: Article
    DOI: 10.1155/2018/8052620
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2045240-8
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  • 6
    Online Resource
    Online Resource
    HMGA1 As a Potential Prognostic and Therapeutic Biomarker in Breast Cancer
    Hindawi Limited ; 2022
    In:  Disease Markers Vol. 2022 ( 2022-11-26), p. 1-12
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2022 ( 2022-11-26), p. 1-12
    Abstract: Background. High-mobility group AT-hook1 (HMGA1) protein plays an important role in various diseases. However, the contribution of HMGA1 in breast cancer remains to be tapped. Methods. The expression of HMGA1 was analyzed in The Cancer Genome Atlas (TCGA) and TIMER database, and immunohistochemistry was performed in 39 breast cancer (BC) patients. The correlation between HMGA1 expression and prognosis was evaluated using Kaplan–Meier plotter (KM plotter) in patients with breast cancer. Then, cBioPortal and bc-GenExMiner were requisitioned to analyze the contribution of HMGA1 expression to clinical features. In order to reveal the function of HMGA1 in breast cancer cells, enrichment analysis was performed using the clusterProfiler R software package. Moreover, CCK8 assay, EdU assay, and Cell Cycle Assay were performed to assess the proliferation, and transwell assay was used to evaluate cell migration and invasion. Flow cytometry was used to explore the role of HMGA1 on cell apoptosis. After that, the effect of HMGA1 on signaling pathways in BC cells was detected by western blot. Results. HMGA1 was highly expressed in a variety of tumors tissues, including BC. High HMGA1 expression was correlated with poor prognosis in BC patients. Meanwhile, HMGA1 expression was increased in molecular phenotypes with poor prognosis (ER-, PR-, and HER2+) and associated with high-grade group, lymph node metastasis, and NPI (Nottingham Prognostic Index). Further, function analysis revealed HMGA1 was enriched in DNA replication and cell cycle pathways in breast cancer. Moreover, knockdown of HMGA1 caused apoptosis, inhibited proliferation, migration, and invasion of MCF-7 and MDA-MB-231 cells, in which the oncogenic signaling pathway of PI3K/AKT/MMP9 played a critical role. Conclusions. HMGA1 was important for breast cancer progression and was a critical prognostic indicator, prompting a potential therapeutic target of breast cancer.
    Type of Medium: Online Resource
    ISSN: 1875-8630 , 0278-0240
    URL: Article
    DOI: 10.1155/2022/7466555
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2033253-1
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