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  • 1
    In: Solar Energy Materials and Solar Cells, Elsevier BV, Vol. 230 ( 2021-09), p. 111278-
    Type of Medium: Online Resource
    ISSN: 0927-0248
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 2012677-3
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  • 2
    Online Resource
    Online Resource
    Spandidos Publications ; 2021
    In:  Experimental and Therapeutic Medicine Vol. 22, No. 3 ( 2021-07-01)
    In: Experimental and Therapeutic Medicine, Spandidos Publications, Vol. 22, No. 3 ( 2021-07-01)
    Type of Medium: Online Resource
    ISSN: 1792-0981 , 1792-1015
    Language: Unknown
    Publisher: Spandidos Publications
    Publication Date: 2021
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  • 3
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 13 ( 2023-7-6)
    Abstract: To explore the early onset, development and histological features of gastric signet-ring cell carcinoma (SRCC). Methods Three hundred and sixty-two patients with differentiated adenocarcinoma with signet-ring cells were enrolled. Histomorphological and immunohistochemical features and patterns of the specimens were observed in detail. Results Infection of the gastric mucosa, especially by Helicobacter pylori , can cause massive cell proliferation and transformation in the deep gastric foveola, the isthmus of the gastric gland, and the proliferative zone of the upper neck of the gland. Signet-ring-like heterocysts monoclonally proliferated after the redifferentiation and reproliferation, extending horizontally along the gastric foveola. Gastric foveolar-type SRCC grew infiltratively into the lamina propria of the mucosa and the submucosa, signet-ring cells could differentiate into undifferentiated adenocarcinoma with signet-ring cell differentiation, mucinous adenocarcinoma with signet-ring cell differentiation, gastric adenocarcinoma with signet-ring cell differentiation, and fundus gland adenocarcinoma with signet-ring cell differentiation. Conclusion Early SRCC developed from the proliferative zones of the fundus of the gastric foveola and the neck of the gastric gland, growing horizontally along the gastric foveola. It developed into gastric adenocarcinoma with signet-ring cell differentiation after reproliferation and retransformation in the mucosa.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2649216-7
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  • 4
    Online Resource
    Online Resource
    Hindawi Limited ; 2020
    In:  Journal of Oncology Vol. 2020 ( 2020-10-13), p. 1-7
    In: Journal of Oncology, Hindawi Limited, Vol. 2020 ( 2020-10-13), p. 1-7
    Abstract: Objective. To explore the relationship between the HER2 gene and PD-1/PD-L1 in gastric cancer and its significance. Methods. Immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) were used to detect HER2 protein expression, HER2 gene amplification, and PD-1/PD-L1 expression in 78 cases of gastric cancer. Results. The expression rate of HER2 protein was 43.6% (34/78), of which 19.4% (14/78) were HER2 3+, 14.1% (11/78) were HER2 2+, and 11.5% (9/78) were HER2 1+. The results showed that 19.2% (15/78) of samples had HER2 gene amplification, 3.8% (3/78) of samples had a HER2/CEP17 ratio 〈 2.0, and 19.2% (15/78) of samples had HER2 gene amplificationf and HER2 copy/cell ≥6.0, as detected by FISH. The positive rate of PD-L1 was 38.5% (30/78) in gastric cancer cells and 50.0% (39/78) in interstitial lymphocytes. The expression of the HER2 gene, PD-L1, and PD-1 in gastric cancer was correlated with the stage and lymph node metastasis of gastric cancer ( P 〈 0.05 ). Conclusions. The combined detection of the HER2 gene and PD-1/PD-L1 in gastric cancer provides an important reference index for the prognosis of gastric cancer and the benefit of targeted antitumor drugs.
    Type of Medium: Online Resource
    ISSN: 1687-8469 , 1687-8450
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2461349-6
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  • 5
    Online Resource
    Online Resource
    Institute of Electrical and Electronics Engineers (IEEE) ; 2019
    In:  IEEE Access Vol. 7 ( 2019), p. 147713-147720
    In: IEEE Access, Institute of Electrical and Electronics Engineers (IEEE), Vol. 7 ( 2019), p. 147713-147720
    Type of Medium: Online Resource
    ISSN: 2169-3536
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2019
    detail.hit.zdb_id: 2687964-5
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  • 6
    In: Gastroenterology Research and Practice, Hindawi Limited, Vol. 2021 ( 2021-3-9), p. 1-11
    Abstract: Objective. To investigate the histomorphological characteristics and pathological types of hyperproliferation of gastric surface epithelial cells. Methods. Hematoxylin and Eosin, Periodic acid–Schiff, and immunohistochemical staining were performed on biopsy specimens obtained from 723 patients with hyperproliferation of gastric surface epithelial cells and/or hyperplasia of gastric pits. Follow-up gastroscopic reexaminations were performed on 475 patients included. Improvement probability was analyzed using Kaplan-Meyer as well as Cox proportional hazards models. Results. Seven different histomorphologies and clinicopathologies of hyperproliferation of gastric surface epithelial cells were identified: (1) common hyperplasia of gastric epithelial cells, which was characterized by focal glandular epithelial hyperplasia of gastric pits with chronic inflammation; (2) drug-induced hyperplasia of gastric epithelial cells, which was characterized by increased hyperplasia of gastric pits and cells arranged in a monolayer; (3) Helicobacter pylori (Hp) infection-induced hyperplasia of gastric epithelial cells, which was characterized by the disappearance of oval, spherical, and bounded membrane-enclosed mucus-containing granules in the cytoplasm and on the nucleus together with cytoplasmic swelling and vacuolation; (4) metaplastic hyperplasia of gastric epithelial cells, which was characterized by the coexistence of intestinal metaplastic cells with hyperplastic gastric epithelial cells; (5) atrophic hyperplasia of gastric epithelial cells, which was characterized by the mucosal atrophy accompanied with hyperplasia of gastric pits; (6) low-grade neoplasia of epithelial cells, which was characterized by the mild to moderate dysplasia of gastric epithelial cells; and (7) high-grade neoplasia of epithelial cells, which was characterized by the evident dysplasia of hyperplastic epithelial cells and losses of cell polarity. The different pathological types are associated with different improvement probabilities. Conclusions. This study demonstrated the histomorphological characteristics and pathological types, which might guide clinicians to track malignant cell transformation, perform precise treatment, predict the clinical prognosis, and control the development of gastric cancer.
    Type of Medium: Online Resource
    ISSN: 1687-630X , 1687-6121
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2435460-0
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  • 7
    Online Resource
    Online Resource
    Inderscience Publishers ; 2015
    In:  International Journal of Reasoning-based Intelligent Systems Vol. 7, No. 3/4 ( 2015), p. 186-
    In: International Journal of Reasoning-based Intelligent Systems, Inderscience Publishers, Vol. 7, No. 3/4 ( 2015), p. 186-
    Type of Medium: Online Resource
    ISSN: 1755-0556 , 1755-0564
    Language: English
    Publisher: Inderscience Publishers
    Publication Date: 2015
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  • 8
    Online Resource
    Online Resource
    Hindawi Limited ; 2021
    In:  Wireless Communications and Mobile Computing Vol. 2021 ( 2021-04-17), p. 1-14
    In: Wireless Communications and Mobile Computing, Hindawi Limited, Vol. 2021 ( 2021-04-17), p. 1-14
    Abstract: In order to improve recognition accuracy of clothing style and fully exploit the advantages of deep learning in extracting deep semantic features from global to local features of clothing images, this paper utilizes the target detection technology and deep residual network (ResNet) to extract comprehensive clothing features, which aims at focusing on clothing itself in the process of feature extraction procedure. Based on that, we propose a multideep feature fusion algorithm for clothing image style recognition. First, we use the improved target detection model to extract the global area, main part, and part areas of clothing, which constitute the image, so as to weaken the influence of the background and other interference factors. Then, the three parts were inputted, respectively, to improve ResNet for feature extraction, which has been trained beforehand. The ResNet model is improved by optimizing the convolution layer in the residual block and adjusting the order of the batch-normalized layer and the activation layer. Finally, the multicategory fusion features were obtained by combining the overall features of the clothing image from the global area, the main part, to the part areas. The experimental results show that the proposed algorithm eliminates the influence of interference factors, makes the recognition process focus on clothing itself, greatly improves the accuracy of the clothing style recognition, and is better than the traditional deep residual network-based methods.
    Type of Medium: Online Resource
    ISSN: 1530-8677 , 1530-8669
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2045240-8
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  • 9
    In: Gastric Cancer, Springer Science and Business Media LLC, Vol. 26, No. 5 ( 2023-09), p. 721-733
    Abstract: To investigate the occurrence and development of gastric mucosal atrophic lesions and their histopathological characteristics. Methods Histopathological diagnosis and immunohistochemical staining using the EnVision two-step method were conducted on 1969 gastric mucosal atrophic lesions obtained from gastroscopic biopsy specimens. A total of 48-month three-stage endoscopic biopsy follow-ups were performed. Results When the gastric mucosal epithelium was affected by infection, chemical irritation, or immune or genetic factors, the gastric mucosal epithelium glands atrophied, the mucosa became thinner, the number of glands decreased, the intestinal epithelium progressed to metaplasia and smooth muscle fibre became hyperplasia. Such changes may lead to the proliferation and dysplasia of epithelial cells of the gastric mucosa and neoplastic hyperplasia in nature; this is referred to as gastric mucosal atrophic lesions in this study. According to this definition, the present study divided gastric mucosal atrophy into four types: (1) glandular atrophy of the lamina propria; (2) compensatory proliferative atrophy; (3) intestinal metaplasia atrophy; and (4) smooth muscle proliferative atrophy. The incidence rates of the above were 40.1% (789/1969), 14.3% (281/1969), 27.8% (547/1969) and 17.9% (352/1969), respectively. One- to 4-year follow-ups found that the changes were not significant and that the percentages of patients with disease exacerbation were 85.7% (1688/1969) and 9.8% (192/1969). The percentages of patients who developed low-grade intraepithelial neoplasia and high-grade intraepithelial neoplasia were 2.8% (55/1969) and 1.1% (21/1969), respectively; 0.7% (13/1969) of patients developed intramucosal cancer. Conclusion Gastric mucosal atrophic lesions and histopathological staging are based on the morphological characteristics of gastric mucosal atrophy and the hypothesis of malignant transformation of cells during the occurrence and development of mucosal atrophy. Mastering pathological staging is beneficial to clinicians for enacting precise treatment and is important for reducing the incidence of gastric cancer.
    Type of Medium: Online Resource
    ISSN: 1436-3291 , 1436-3305
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 1481763-9
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  • 10
    In: Food and Chemical Toxicology, Elsevier BV, Vol. 108 ( 2017-10), p. 467-477
    Type of Medium: Online Resource
    ISSN: 0278-6915
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2017
    detail.hit.zdb_id: 1483645-2
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