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  • Wang, Shutao  (4)
  • Zhang, Xiaobin  (4)
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  • 1
    Online Resource
    Online Resource
    Self‐Pumping Janus Hydrogel with Aligned Channels for Accelerating Diabetic Wound Healing
    Wiley ; 2023
    In:  Macromolecular Rapid Communications Vol. 44, No. 7 ( 2023-04)
    Details
    In: Macromolecular Rapid Communications, Wiley, Vol. 44, No. 7 ( 2023-04)
    Abstract: Excessive exudate secreted from diabetic wounds often results in skin overhydration, severe infections, and secondary damage upon dressing changes. However, conventional wound dressings are difficult to synchronously realize the non‐maceration of wound sites and rapid exudate transport due to their random porous structure. Herein, a self‐pumping Janus hydrogel with aligned channels (JHA) composed of hydrophilic poly (ethylene glycol) diacrylate (PEGDA) hydrogel layer and hydrophobic polyurethane (PU)/graphene oxide (GO)/polytetrafluoroethylene (PTFE) layer is designed to rapidly export exudate and accelerate diabetic wound healing. In the design, the ice‐templating process endows the hydrophilic hydrogel layer with superior liquid transport ability and mechanical strength due to the formation of aligned channel structure. The hydrophobic layer with controlled thickness functions as an effective barrier to prevent exudate from wetting the skin surface. Experiments in diabetic rat model show that JHA can significantly promote re‐epithelialization and collagen deposition, shorten the inflammation phase, and accelerate wound healing. This unique JHA dressing may have great potential for real‐life usage in clinical patients.
    Type of Medium: Online Resource
    ISSN: 1022-1336 , 1521-3927
    URL: Issue
    URL: Article
    DOI: 10.1002/marc.v44.7
    DOI: 10.1002/marc.202200814
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1475027-2
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Video2.AVI
    Frontiers Media SA ; 2023
    In:  Frontiers in Bioengineering and Biotechnology Vol. 11 ( 2023-4-4)
    Details
    In: Frontiers in Bioengineering and Biotechnology, Frontiers Media SA, Vol. 11 ( 2023-4-4)
    Abstract: Massive exudates oversecreted from burn wounds always delay the healing process, accompanied by undesired adhesion, continuous inflammation, and high infection risk. Conventional dressings with limited draining ability cannot effectively remove the excessive exudates but constrain them in the wetted dressings immersing the wound bed. Herein, we fabricate an enhanced fractal self-pumping dressing by floating and accumulating hollow glass microspheres in the hydrogel precursor, that can continuously drain water at a non-declining high speed and effectively promote burn wound healing. Small hollow glass microspheres can split the fractal microchannels into smaller ones with higher fractal dimensions, resulting in higher absorption efficiency. In an in vivo burn wound model on the dorsum of murine, the enhanced fractal self-pumping dressing can significantly reduce the appearance of the wound area and alleviate tissue edema along the healing process. This study sheds light on designing high-efficiency and continuous-draining dressings for clinical applications.
    Type of Medium: Online Resource
    ISSN: 2296-4185
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fbioe.2023.1188782
    DOI: 10.3389/fbioe.2023.1188782.s001
    DOI: 10.3389/fbioe.2023.1188782.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2719493-0
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Design of Adhesive Hemostatic Hydrogels Guided by the Interfacial Interactions with Tissue Surface
    Wiley ; 2023
    In:  Advanced NanoBiomed Research Vol. 3, No. 2 ( 2023-02)
    Details
    In: Advanced NanoBiomed Research, Wiley, Vol. 3, No. 2 ( 2023-02)
    Abstract: Adhesive hemostatic hydrogels, as one of the most important wound dressings, have attracted tremendous attention because of their unique advantages in injured tissue. Many intensive efforts are devoted to designing ingenious adhesive hemostatic hydrogels based on interfacial interactions with tissue surfaces, such as covalent bonds, hydrogen bonds, electrostatic interactions, cation–π interactions, and π–π stacking interactions. Herein, an overview of the recent progress in adhesive hemostatic hydrogels is provided, especially focusing on diverse covalent/noncovalent interfacial interactions between the active groups of adhesive hydrogels and tissue surface. The commonly used forms and the hemostatic evaluation models of the adhesive hydrogels are also summarized. Finally, the critical issues that should be concerned for current adhesive hemostatic hydrogels and the developing directions toward practical applications are discussed.
    Type of Medium: Online Resource
    ISSN: 2699-9307 , 2699-9307
    URL: Issue
    URL: Article
    DOI: 10.1002/anbr.v3.2
    DOI: 10.1002/anbr.202200115
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 3009938-9
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    Online Resource
  • 4
    Online Resource
    Online Resource
    A Rapid Self‐Pumping Organohydrogel Dressing with Hydrophilic Fractal Microchannels to Promote Burn Wound Healing
    Wiley ; 2023
    In:  Advanced Materials Vol. 35, No. 38 ( 2023-09)
    Details
    In: Advanced Materials, Wiley, Vol. 35, No. 38 ( 2023-09)
    Abstract: Burn wounds pose great challenges for conventional dressings because massive exudates oversecreted from swollen tissues and blisters seriously delay wound healing. Herein, a self‐pumping organohydrogel dressing with hydrophilic fractal microchannels is reported that can rapidly drain excessive exudates with ≈30 times enhancement in efficiency compared with the pure hydrogel, and effectively promote burn wound healing. A creaming‐assistant emulsion interfacial polymerization approach is proposed to create the hydrophilic fractal hydrogel microchannels in the self‐pumping organohydrogel through a dynamic floating‐colliding‐coalescing process of organogel precursor droplets. In a murine burn wound model, the rapid self‐pumping organohydrogel dressings can markedly reduce dermal cavity by ≈42.5%, accelerate blood vessel regeneration by ≈6.6 times, and hair follicle regeneration by ≈13.5 times, compared with the commercial dressing (Tegaderm). This study paves an avenue for designing high‐performance functional burn wound dressings.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v35.38
    DOI: 10.1002/adma.202301765
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1474949-X
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