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  • Oxford University Press (OUP)  (6)
  • Wang, Qifeng  (6)
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  • Oxford University Press (OUP)  (6)
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  • 1
    Online Resource
    Online Resource
    365. PROGNOSTIC COMPARISON OF LYMPHOVASCULAR INVASION AND LYMPH NODE METASTASIS IN ESOPHAGEAL CANCER PATIENTS
    Oxford University Press (OUP) ; 2022
    In:  Diseases of the Esophagus Vol. 35, No. Supplement_2 ( 2022-09-24)
    Details
    In: Diseases of the Esophagus, Oxford University Press (OUP), Vol. 35, No. Supplement_2 ( 2022-09-24)
    Abstract: The incidence and mortality of esophageal cancer are high-ranking in the world, more than half of cases occur in China. The cornerstone of treatment for resectable esophageal cancer is esophagectomy. Lymphovascular invasion and lymph node metastasis are both vital prognostic factors for patients who have been through esophagectomy. But in fact, the combined influence of these two factors on prognosis remains controversial. Samples were obtained from the Sichuan Cancer Hospital & Institute Esophageal Cancer Case Management Database (SCH-ECCM Database). We retrospectively analyzed esophageal cancer patients who underwent esophagectomy from Jan. 2010 to Dec. 2016. Patients were divided into two groups according to the postoperative pathological outcomes: patients with only lymph node metastasis were pointed into group A, patients with only lymphovascular invasion were distributed to group B. Clinical outcomes and survival data were compared using TNM stages of AJCC 8th edition. After 68.1 months of median follow-up time, 1596 patients who received esophagectomy were included. The median overall survival (OS) was 45.9 months (95% CI 38.5–53.2). Only lymph node metastasis group achieved median OS of 34.9 months (95% CI 30.7–39.1), however, only lymphovascular invasion group did not reach the median OS time. The OS at 1, 3, and 5 years were 91%, 70%, and 64% in the only lymphovascular invasion group group, respectively. In the only lymph node metastasis group, the OS rates at 1, 3, and 5 years were 82%, 49%, and 37%, respectively (HR 0.438, 95% CI 0.3074–0.624, P = 0.0012). Esophageal cancer patients with only lymph node metastasis had significantly worse OS than the patients with only lymphovascular invasion. It reveals that we should pay more attention to these risk factors, and further studies need to be done to stratify the accurate subgroups.
    Type of Medium: Online Resource
    ISSN: 1120-8694 , 1442-2050
    URL: Article
    DOI: 10.1093/dote/doac051.365
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2004949-3
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  • 2
    Online Resource
    Online Resource
    373. STRATEGIES ON OPTIMAL LYMPHADENECTOMY IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA: A RETROSPECTIVE ANALYSIS OF 1517 CASES IN A SINGLE CANCER CENTER
    Oxford University Press (OUP) ; 2022
    In:  Diseases of the Esophagus Vol. 35, No. Supplement_2 ( 2022-09-24)
    Details
    In: Diseases of the Esophagus, Oxford University Press (OUP), Vol. 35, No. Supplement_2 ( 2022-09-24)
    Abstract: The incidence and mortality of esophageal cancer are high-ranking in the world in cancer, it is the forth primary cause of cancer-related death and has the sixth highest incidence rate in China. Our purpose is to discuss the impact of the number of lymph nodes dissection in esophagectomy for esophageal squamous cell carcinoma to patients’ overall survival (OS), especially in the patients who have positive lymph nodes in recent years. Data were from the Sichuan Cancer Hospital & Institute Esophageal Cancer Case Management Database. We retrospective analyzed patients who underwent esophagectomy from Jan. 2010 to Dec. 2016. Patients were divided into two groups: Negative lymph nodes in the pathological results were assigned to N0 group, while patients with positive lymph nodes were divided into N+ group. The median number of resected lymph nodes (RLNs) during operation was 24, patients were assigned to group A/N0 and A/N+ according to RLNs number of 15–24, and number of RLNs more than 24 were assigned to group B/N0 and B/N+. After 62.8 months of median follow-up time, 1517 patients who received esophagectomy were included. In the N+ group, the median overall survival (OS) of N+ A group was 27.8 months (95% CI 23.8–31.8) compared to N+ B group was 33.3 months (95% CI 28.2–38.5). The OS at 1, 3, and 5 years were 80%, 40%, and 30% in the N+ A group, and there were 82%, 48%, and 35% in the N+ B group, respectively (P = 0.038  & lt; 0.05). (HR 1.18, 95% CI 1.008–1.380, P = 0.038). Increasing the harvest of number of lymph nodes during surgery more than 24 could improve the OS of esophageal squamous cell carcinoma patients. It is demonstrated patients without lymph metastasis have a better OS than those with lymph metastasis. When we reached dissection more than 15 lymph nodes, there will be no more benefits in OS for further harvest of lymph node numbers. Patients with different stages may be given different lymph nodes dissection strategies.
    Type of Medium: Online Resource
    ISSN: 1120-8694 , 1442-2050
    URL: Article
    DOI: 10.1093/dote/doac051.373
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2004949-3
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  • 3
    Online Resource
    Online Resource
    696 LONG-TERM OUTCOMES OF MINIMALLY INVASIVE ESOPHAGECTOMY COMPARED TO OPEN ESOPHAGECTOMY: A RETROSPECTIVE ANALYSIS OF 2958 CASES IN SINGLE CANCER CENTER
    Oxford University Press (OUP) ; 2021
    In:  Diseases of the Esophagus Vol. 34, No. Supplement_1 ( 2021-09-17)
    Details
    In: Diseases of the Esophagus, Oxford University Press (OUP), Vol. 34, No. Supplement_1 ( 2021-09-17)
    Abstract: Esophageal cancer is the fourth primary cause of cancer-related death in the male in China.The cornerstone of treatment for resectable esophageal cancer is surgery. With the development of minimally invasive esophagectomy (MIE), it is gradually adopted as an alternative to open esophagectomy (OE) in real-world practice. The purpose of this study is to explore whether MIE vs. OE will bring survival benefits to patients with the advancement of treatment techniques and concepts. Methods Data were obtained from the Sichuan Cancer Hospital & Institute Esophageal Cancer Case Management Database (SCH-ECCM Database). We retrospective analyzed esophageal cancer patients who underwent esophagectomy from Jan. 2010 to Nov. 2017. Patients were divided into two groups: MIE and OE groups. Clinical outcome and survival data were compared using TNM stages of AJCC 8th edition. Results After 65.3 months of median follow-up time, 2958 patients who received esophagectomy were included. 1106 of 2958 patients (37.4%) were underwent MIE, 1533 of 2958 patients (51.8%) were underwent OE. More than half of the patients (56.7%, 1673/2958) were above stage III. The median overall survival (OS) of 2958 patients was 51.6 months (95% CI 45.2–58.1). The MIE group's median OS was 74.6 months compared to 42.4 months in the OE group (95% CI 1.23–1.54, P  & lt; 0.001). The OS at 1, 3, and 5 years were 90%, 68%, 58% in the MIE group; 85%, 54%, 42% in the OE group,respectively (P & lt;0.001). Conclusion The nearly 8-year follow-up data from this single cancer center suggests that with the advancement of minimally invasive surgical technology, MIE can bring significant benefits to patients' long-term survival compared with OE. Following the continuous progression of minimally invasive surgery and establishing a mature surgical team, MIE should be encouraged.
    Type of Medium: Online Resource
    ISSN: 1120-8694 , 1442-2050
    URL: Article
    DOI: 10.1093/dote/doab052.696
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2004949-3
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  • 4
    Online Resource
    Online Resource
    366. SURGERY VERSUS NON-SURGICAL TREATMENT FOR THORACIC ESOPHAGEAL CANCER IN PATIENTS OLDER THAN 70 YEARS: A RETROSPECTIVE ANALYSIS OF 749 CASES
    Oxford University Press (OUP) ; 2022
    In:  Diseases of the Esophagus Vol. 35, No. Supplement_2 ( 2022-09-24)
    Details
    In: Diseases of the Esophagus, Oxford University Press (OUP), Vol. 35, No. Supplement_2 ( 2022-09-24)
    Abstract: The highest incidence of esophageal cancer is in East Asia, but as for advanced age people, there are also many non-tumor factors affecting overall survival (OS), such as cardiovascular and cerebrovascular diseases. Our purpose is to determine whether the older patients after esophagectomy had better OS than those treated with non-surgical treatment. Data were obtained from the Sichuan Cancer Hospital & Institute Esophageal Cancer Case Management Database (SCH-ECCM Database) and Department of Radiation Oncology Database. We retrospective analyzed esophageal cancer patients older than 70 years who underwent esophagectomy or radiotherapy/chemotherapy from Jan. 2009 to Dec. 2017. The patients were divided into two groups: surgery group (S group), and non-surgery group (NS group). Outcome measures depend on OS. After 60.6 months of median follow-up time, 749 patients were included. 532 of 749 patients (71.0%) underwent surgery, 217 of 749 patients (39.0%) underwent non-surgical treatment including radiotherapy and/or chemotherapy. In the S group, the median OS of was 39.7 months (95% CI 33.7–45.7), while the NS group was only 24.0 months (95% CI 19.6–28.4). The OS at 1, 3, and 5 years were 84%, 52%, and 39% in the S group, respectively. In the NS group, the OS rates at 1, 3, and 5 years were 72%, 32%, and 29%, respectively (HR 0.69, 95% CI 0.561–0.846, P & lt;0.0001). Esophageal cancer patients older than 70 years who underwent esophagectomy had significantly better OS than those who underwent non-surgical treatment based on radiotherapy and/or chemotherapy.
    Type of Medium: Online Resource
    ISSN: 1120-8694 , 1442-2050
    URL: Article
    DOI: 10.1093/dote/doac051.366
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2004949-3
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  • 5
    Online Resource
    Online Resource
    362. CLINICAL VALUE AND EFFICACY INDEX OF LYMPHADENECTOMY FOR THORACIC ESOPHAGEAL SQUAMOUS CELL CARCINOMA
    Oxford University Press (OUP) ; 2022
    In:  Diseases of the Esophagus Vol. 35, No. Supplement_2 ( 2022-09-24)
    Details
    In: Diseases of the Esophagus, Oxford University Press (OUP), Vol. 35, No. Supplement_2 ( 2022-09-24)
    Abstract: Esophageal squamous cell carcinoma (ESCC) has high mortality in China. The cornerstone of treatment for resectable esophageal cancer is still surgery. It is vital to find the regularity of lymph node metastasis and the value of dissection for thoracic ESCC in China, to provide a basis for accurate staging and the relationship between overall survival (OS) and lymph node dissection. Cases were collected from 2957 patients in Sichuan Cancer Hospital & Institute Esophageal Cancer Case Management Database (SCH-ECCM Database) from January 2010 to August 2017. The stations of lymph node were referenced according to CSCO diagnosis and treatment guidelines and JES, 11th Ed. According to the frequency and patient’s survival of metastases to each station of investigated tumor location were used to calculate the Efficacy Index (EI). EI was calculated by multiplying the frequency (%) and 5-year survival rate of metastases (%) in patients, and then dividing by the number of 100. The median follow-up time was 59.5 months. The EI was high in supraclavicular and mediastinal zones in patients with upper esophageal tumors, and the EI of 106recR was 13.72, which was the highest among lymph node stations. The EI was high in mediastinal zone followed by celiac and supraclavicular zones in patients with middle esophageal tumors, 104R with EI of 15.54 was the highest among lymph node stations. As for patients with lower esophageal tumors, the EI was high in celiac zone followed by mediastinal zones, the EI of left gastric artery was 10.86, over every lymph node stations. The EI of right recurrent nerve lymph nodes is the highest in upper esophageal cancer, as for middle esophageal cancer right supraclavicular lymph nodes had high metastasis rate and EI, but the left gastric lymph nodes had high metastasis rate and EI in the lower esophageal cancer. Although the lymph node metastasis rate of ESCC is still high, the more efficient lymphadenectomy should be considered based on further studies.
    Type of Medium: Online Resource
    ISSN: 1120-8694 , 1442-2050
    URL: Article
    DOI: 10.1093/dote/doac051.362
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
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  • 6
    Online Resource
    Online Resource
    376. THE IMPACT OF OVERALL SURVIVAL ON TWO-FIELD OR THREE-FIELD LYMPHADENECTOMY IN MIDDLE AND LOWER THORACIC ESOPHAGEAL SQUAMOUS CELL CARCINOMA
    Oxford University Press (OUP) ; 2022
    In:  Diseases of the Esophagus Vol. 35, No. Supplement_2 ( 2022-09-24)
    Details
    In: Diseases of the Esophagus, Oxford University Press (OUP), Vol. 35, No. Supplement_2 ( 2022-09-24)
    Abstract: More than 50% of esophageal cancer cases worldwide occur in China. Squamous cell carcinoma is the main subtype of esophageal cancer in East Asian. The manner of lymphadenectomy during surgery is related to the OS, but the effect of removed lymph node count for middle and lower thoracic esophageal squamous cell carcinoma (ESCC) in China is still controversial. Data were obtained from the Sichuan Cancer Hospital & Institute Esophageal Cancer Case Management Database (SCH-ECCM Database) from Jan. 2010 to Dec. 2017. Patients were divided into two groups: For patients without suspicious tumor-positive cervical lymph nodes, 2-field systematic lymphadenectomy was performed and were belonged 2F group, while patients with suspicious tumor-positive cervical lymph nodes, 3-field systematic lymphadenectomy was performed and were put into 3F group. According to the quartile number of resected lymph nodes during operation. Four subgroups were designed for analysis in 2F group and 3F group, depending on the intensity of the lymphadenectomy. After 60.0 months (95% CI 56.5–63.4) of median follow-up time. The median OS of 2F group patients was 46.9 months (95% CI 39.3–54.5), 3F group was 34.0 months (95% CI 26.1–42.0). The OS at 1, 3, and 5 years were 87%, 57%, and 46% in the 2F group. In the 3F group, the OS rates at 1, 3, and 5 years were 82%, 49%, and 41% (P = 0.029). According to the quartile number of RLNs, there were different survival outcomes in 3F sub-groups, while in the 2F groups, the OS between A/B/C/D group was not significantly different (Fig A & B). ESCC patients with suspicious tumor-positive cervical lymph nodes have significantly worse OS than patients who without tumor-positive cervical lymph nodes. Different lymph nodes number removed in 3F patients could lead the entirely different survival outcomes. However, this still needs further large scale study to verify in China.
    Type of Medium: Online Resource
    ISSN: 1120-8694 , 1442-2050
    URL: Article
    DOI: 10.1093/dote/doac051.376
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2004949-3
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