In:
Journal of Occupational Health, Wiley, Vol. 54, No. 4 ( 2012-07), p. 263-270
Abstract:
Estimation of a Safe Level for Occupational Exposure to Vinyl Chloride Using a Benchmark Dose Method in Central China: Jie JIAO, et al . Department of Occupational Health and Toxicology, School of Public Health, Fudan University, China— Objectives The aim of this study was to estimate a benchmark dose (BMD) for chromosome damage induced by vinyl chloride monomer (VCM) in VCMexposed workers in central China and validate the published results in Shanghai. Methods VCMexposed workers who had been exposed to VCM for at least one year (n=463) and matched subjects not exposed to VCM or other toxins (n=273) were asked to participate in this study. Micronucleus (MN) frequency based on the cytokinesis‐block micronucleus assay (CBMN) was used as a biomarker for chromosome damage induced by VCM exposure. Results The MN frequency in the VCM‐exposed workers was significantly higher than that in the control group, and multivariate Poisson regression suggested that gender, smoking status and VCM exposure were the significant factors influencing the risk of increased MN frequency. When subjects were further stratified according to gender and smoking status, the results showed that female VCMexposed workers were more susceptible than the males to the risk of increased MN frequency. The MN frequency of smokers was significantly higher than that of nonsmokers in the control group. Our study also suggested that there was a strong dose‐response relationship between VCM CED and the increased risk of MN frequency in the total group, males and females. The BMDL 10 was found to be 630.6, 670.2 and 273.7 mgyear for all VCM‐exposed workers, males and females, respectively. Conclusions These results invite further scrutiny of the current VCM occupational exposure limits and warrant further study of the risk of VCM genotoxicity and carcinogenicity.
Type of Medium:
Online Resource
ISSN:
1341-9145
,
1348-9585
DOI:
10.1539/joh.11-0157-OA
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
1340985-2
detail.hit.zdb_id:
2075956-3
Permalink
