In:
Frontiers in Microbiology, Frontiers Media SA, Vol. 14 ( 2023-7-21)
Abstract:
Monkeypox (mpox) is a zoonotic infectious disease caused by the mpox virus. Mpox symptoms are similar to smallpox with less severity and lower mortality. As yet mpox virus is not characterized by as high transmissibility as some severe acute respiratory syndrome 2 (SARS-CoV-2) variants, still, it is spreading, especially among men who have sex with men (MSM). Thus, taking preventive measures, such as vaccination, is highly recommended. While the smallpox vaccine has demonstrated considerable efficacy against the mpox virus due to the antigenic similarities, the development of a universal anti-mpox vaccine remains a necessary pursuit. Recently, nucleic acid vaccines have garnered special attention owing to their numerous advantages compared to traditional vaccines. Importantly, DNA vaccines have certain advantages over mRNA vaccines. In this study, a potentially universal DNA vaccine candidate against mpox based on conserved epitopes was designed and its efficacy was evaluated via an immunoinformatics approach. The vaccine candidate demonstrated potent humoral and cellular immune responses in silico , indicating the potential efficacy in vivo and the need for further research.
Type of Medium:
Online Resource
ISSN:
1664-302X
DOI:
10.3389/fmicb.2023.1203355
DOI:
10.3389/fmicb.2023.1203355.s001
DOI:
10.3389/fmicb.2023.1203355.s002
DOI:
10.3389/fmicb.2023.1203355.s003
DOI:
10.3389/fmicb.2023.1203355.s004
DOI:
10.3389/fmicb.2023.1203355.s005
DOI:
10.3389/fmicb.2023.1203355.s006
DOI:
10.3389/fmicb.2023.1203355.s007
DOI:
10.3389/fmicb.2023.1203355.s008
DOI:
10.3389/fmicb.2023.1203355.s009
DOI:
10.3389/fmicb.2023.1203355.s010
DOI:
10.3389/fmicb.2023.1203355.s011
DOI:
10.3389/fmicb.2023.1203355.s012
DOI:
10.3389/fmicb.2023.1203355.s013
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2023
detail.hit.zdb_id:
2587354-4
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