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  • 1
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    Cultivated Land Quality Evaluated Using the RNN Algorithm Based on Multisource Data
    MDPI AG ; 2022
    In:  Remote Sensing Vol. 14, No. 23 ( 2022-11-27), p. 6014-
    Details
    In: Remote Sensing, MDPI AG, Vol. 14, No. 23 ( 2022-11-27), p. 6014-
    Abstract: Cultivated land quality (CLQ) is associated with national food security, benign economic development, social harmony, and stability. The scientific evaluation of CLQ provides the basis for achieving the “trinity” protection of cultivated land quantity, and quality, as well as ecology. However, the current research on CLQ evaluation has some limitations, mainly the poor consideration of evaluation indicators, time-consuming and labor-intensive data acquisition, and low precision of evaluation at the regional scale. Therefore, this study introduced multisource data to evaluate CLQ and proposed a new method for CLQ evaluation (natural grade evaluation, utilization grade evaluation, and economic grade evaluation), combining multisource data and the recurrent neural network (RNN) algorithm. Initially, optimal indicators were determined by correlation analysis and generalized linear regression coefficient methods based on factors related to CLQ acquired from multisource data. Then, CLQ evaluation models were constructed with the RNN algorithm on the basis of the aforementioned optimal indicators. Finally, the models were adopted to map CLQ. The present study was carried out in Guangzhou City, Guangdong Province, China. According to the results: (1) CLQ showed close relationship to pH, effective soil layer thickness (EST), chemical fertilizer application rate (CHFE), organic matter content (OMC), annual accumulated temperature (TEMA), 5–15 cm soil depth soil cation exchange capacity (CEC515), 0–5 cm soil depth soil cation exchange capacity (CEC05), 5–15 cm soil depth soil organic carbon content (SOC515), 0–5 cm soil depth soil organic carbon content (SOC05), field slope (FS), groundwater level (GWL), and terrain slope (TS). (2) All modeling accuracies (R2) were greater than 0.80 for the CLQ evaluation models constructed based on the RNN algorithm. The area and spatial distribution of each grade of CLQ evaluation were consistent with the actual situation. The best and the worst quality cultivated land occupied a small area, and the area without a gap with the actual CLQ was as high as 76%, indicating that the model results were reliable. The study shows the suitability of the method for evaluating CLQ at the regional scale, offering a scientific foundation for the rational utilization and management of cultivated land resources, as well as a reference for evaluating CLQ in the future.
    Type of Medium: Online Resource
    ISSN: 2072-4292
    URL: Article
    DOI: 10.3390/rs14236014
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2513863-7
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  • 2
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    Hsa_circ_0001666 suppresses the progression of colorectal cancer through the miR‐576‐5p/PCDH10 axis
    Wiley ; 2021
    In:  Clinical and Translational Medicine Vol. 11, No. 11 ( 2021-11)
    Details
    In: Clinical and Translational Medicine, Wiley, Vol. 11, No. 11 ( 2021-11)
    Abstract: Though circular RNAs, new non‐coding RNA classes have demonstrated that they have an essential role in the initiation as well as development of CRC (colorectal cancer), whereas in CRC the function and mechanism of hsa_circ_0001666 are less known. Methods Hsa_circ_0001666 was identified by bioinformatics analysis of a circRNA microarray from the GEO database, and its expression in both CRC cell lines and tissues was analysed. A series of in vitro along with in vivo experiments were carried out for exploring the hsa_circ_0001666 functions, including transwell, wound healing, flow cytometry, colony formation, Edu, CCK‐8, soft agar colony formation, tumor xenografts and lung/liver metastasis in mice. RNA pull‐down, RIP (RNA immunoprecipitation), luciferase reporter assay, FISH (fluorescence in situ hybridization) and rescue experiments were used for determining the correlation among hsa_circ_0001666, miR‐576‐5p and PCDH10. Results Hsa_circ_0001666 was downregulated in both CRC cell lines along with tumour tissues. A higher expression level of hsa_circ_0001666 indicated a better clinical prognosis in patients with CRC. Hsa_circ_0001666 knockdown significantly supported CRC cell proliferation along with invasion and inhibited cell apoptosis in vitro. Hsa_circ_0001666 knockdown accelerated the CRC growth and metastasis in vivo. Moreover, the mechanistic study showed that hsa_circ_0001666, acting as ‘ceRNA’ of miR‐576‐5p, prevented PCDH10 downregulation, as well as suppressed EMT and stemness of CRC cells, and the Wnt/β‐catenin signalling pathway. Inhibiting miR‐576‐5p or overexpressing PCDH10 could reverse phenotypic changes caused by knocking down of hsa_circ_0001666. Conclusions Hsa_circ_0001666 suppresses CRC progression through the miR‐576‐5p/PCDH10 axis and may provide a new insight for the diagnosis and treatment of CRC.
    Type of Medium: Online Resource
    ISSN: 2001-1326 , 2001-1326
    URL: Issue
    URL: Article
    DOI: 10.1002/ctm2.v11.11
    DOI: 10.1002/ctm2.565
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2697013-2
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  • 3
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    Land-Use Modes of the Dike–Pond System in the Pearl River Delta of China and Implications for Rural Revitalization
    MDPI AG ; 2021
    In:  Land Vol. 10, No. 5 ( 2021-04-23), p. 455-
    Details
    In: Land, MDPI AG, Vol. 10, No. 5 ( 2021-04-23), p. 455-
    Abstract: Rural revitalization is a global problem. The measures should be adjusted to local conditions to make targeted efforts. Natural and socioeconomic resource factors should be considered in rural revitalization. Therefore, this study focuses on the dike–pond system, which is an important traditional agricultural cultural heritage in the Pearl River Delta of China, to illustrate the importance of identifying the utilization mode of a certain land-use type in village integrated with socioeconomic factors to promote rural revitalization. The study used principal component analysis (PCA) and the variance inflation factor (VIF) to identify the main factors influencing the land-use modes of the dike–pond systems, systematic cluster analysis to identify the modes, and interpretive structural modeling to clarify the influence relationships and structures of the factors. We found that the seven modes reflected the different characteristics, organizational structures, and interaction relationships of the factors. There were significant differences in the ecological processes between the seven modes. More detailed village planning should be performed. Strengthening the economic affordability of the operator should be regarded as important in policy guidance and support measures. Agricultural support measures need to be adjusted to different land-use type systems, and localized resources should be revitalized by the theory of “human–earth–sphere”.
    Type of Medium: Online Resource
    ISSN: 2073-445X
    URL: Article
    DOI: 10.3390/land10050455
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2682955-1
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  • 4
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    Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac4C acetylation of KIF23 mRNA
    Springer Science and Business Media LLC ; 2022
    In:  Journal of Experimental & Clinical Cancer Research Vol. 41, No. 1 ( 2022-12-15)
    Details
    In: Journal of Experimental & Clinical Cancer Research, Springer Science and Business Media LLC, Vol. 41, No. 1 ( 2022-12-15)
    Abstract: N 4 -acetylcytidine (ac 4 C) as a significant RNA modification has been reported to maintain the stability of mRNA and to regulate the translation process. However, the roles of both ac 4 C and its ‘writer’ protein N-acetyltransferase 10 (NAT10) played in the disease especially colorectal cancer (CRC) are unclear. At this point, we discover the underlying mechanism of NAT10 modulating the progression of CRC via mRNA ac 4 C modification. Methods The clinical significance of NAT10 was explored based on the TCGA and GEO data sets and the 80 CRC patients cohort of our hospital. qRT-PCR, dot blot, WB, and IHC were performed to detect the level of NAT10 and ac 4 C modification in CRC tissues and matched adjacent tissues. CCK-8, colony formation, transwell assay, mouse xenograft, and other in vivo and in vitro experiments were conducted to probe the biological functions of NAT10. The potential mechanisms of NAT10 in CRC were clarified by RNA-seq, RIP-seq, acRIP-seq, luciferase reporter assays, etc. Results The levels of NAT10 and ac 4 C modification were significantly upregulated. Also, the high expression of NAT10 had important clinical values like poor prognosis, lymph node metastasis, distant metastasis, etc. Furthermore, the in vitro experiments showed that NAT10 could inhibit apoptosis and enhance the proliferation, migration, and invasion of CRC cells and also arrest them in the G2/M phase. The in vivo experiments discovered that NAT10 could promote tumor growth and liver/lung metastasis. In terms of mechanism, NAT10 could mediate the stability of KIF23 mRNA by binding to its mRNA 3’UTR region and up-regulating its mRNA ac 4 c modification. And then the protein level of KIF23 was elevated to activate the Wnt/β-catenin pathway and more β-catenin was transported into the nucleus which led to the CRC progression. Besides, the inhibitor of NAT10, remodelin, was applied in vitro and vivo which showed an inhibitory effect on the CRC cells. Conclusions NAT10 promotes the CRC progression through the NAT10/KIF23/GSK-3β/β-catenin axis and its expression is mediated by GSK-3β which forms a feedback loop. Our findings provide a potential prognosis or therapeutic target for CRC and remodelin deserves more attention. Graphical Abstract
    Type of Medium: Online Resource
    ISSN: 1756-9966
    URL: Article
    DOI: 10.1186/s13046-022-02551-7
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2430698-8
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  • 5
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    Estimation of Soil Nutrient Content Using Hyperspectral Data
    MDPI AG ; 2021
    In:  Agriculture Vol. 11, No. 11 ( 2021-11-11), p. 1129-
    Details
    In: Agriculture, MDPI AG, Vol. 11, No. 11 ( 2021-11-11), p. 1129-
    Abstract: Soil nutrients play a vital role in plant growth and thus the rapid acquisition of soil nutrient content is of great significance for agricultural sustainable development. Hyperspectral remote-sensing techniques allow for the quick monitoring of soil nutrients. However, at present, obtaining accurate estimates proves to be difficult due to the weak spectral features of soil nutrients and the low accuracy of soil nutrient estimation models. This study proposed a new method to improve soil nutrient estimation. Firstly, for obtaining characteristic variables, we employed partial least squares regression (PLSR) fit degree to select an optimal screening algorithm from three algorithms (Pearson correlation coefficient, PCC; least absolute shrinkage and selection operator, LASSO; and gradient boosting decision tree, GBDT). Secondly, linear (multi-linear regression, MLR; ridge regression, RR) and nonlinear (support vector machine, SVM; and back propagation neural network with genetic algorithm optimization, GABP) algorithms with 10-fold cross-validation were implemented to determine the most accurate model for estimating soil total nitrogen (TN), total phosphorus (TP), and total potassium (TK) contents. Finally, the new method was used to map the soil TK content at a regional scale using the soil component spectral variables retrieved by the fully constrained least squares (FCLS) method based on an image from the HuanJing-1A Hyperspectral Imager (HJ-1A HSI) of the Conghua District of Guangzhou, China. The results identified the GBDT-GABP was observed as the most accurate estimation method of soil TN ( of 0.69, the root mean square error of cross-validation (RMSECV) of 0.35 g kg−1 and ratio of performance to interquartile range (RPIQ) of 2.03) and TP ( of 0.73, RMSECV of 0.30 g kg−1 and RPIQ = 2.10), and the LASSO-GABP proved to be optimal for soil TK estimations ( of 0.82, RMSECV of 3.39 g kg−1 and RPIQ = 3.57). Additionally, the highly accurate LASSO-GABP-estimated soil TK (R2 = 0.79) reveals the feasibility of the LASSO-GABP method to retrieve soil TK content at the regional scale.
    Type of Medium: Online Resource
    ISSN: 2077-0472
    URL: Article
    DOI: 10.3390/agriculture11111129
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2651678-0
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  • 6
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    Spatial Variation and Influencing Factors of Trace Elements in Farmland in a Lateritic Red Soil Region of China
    MDPI AG ; 2022
    In:  Agronomy Vol. 12, No. 2 ( 2022-02-14), p. 478-
    Details
    In: Agronomy, MDPI AG, Vol. 12, No. 2 ( 2022-02-14), p. 478-
    Abstract: Trace elements in farmland soil are important indicators of soil quality and farmland health, and also maintain the nutrient balance and promote the healthy growth of plants. In this study, taking Conghua District of Guangzhou city as the study area, the effects of topography, soil, land use, and other factors on trace elements in soil were investigated, and the spatial variability of boron (B), manganese (Mn), molybdenum (Mo), copper (Cu), and zinc (Zn) in farmland soil in a typical red soil region were mapped using a geographically weighted regression (GWR) method. The pH and land economic index (LEI) were important factors affecting the changes in trace element concentrations in the five soils, and the Cu and Zn concentrations were clearly affected by human factors. In the study area, 86.99% of B measurements were classified as low and very low levels, 50.61% and 49.20% of Mo measurements were also low and very low, 71.79% of Mn measurements were classified as moderate, while 91.02% of Cu and 52.95% of Zn measurements were classified as high. After a cross validation, the GWR Kriging (GWRK) model results of each element were relatively stable, and the order of the fitting coefficient (R2) was Cu 〉 Zn 〉 B 〉 Mn 〉 Mo. This study clarifies the spatial distribution and influencing factors of soil microelements in the studied region. This information can be used to improve the nutrient imbalance, further guide agricultural production, strengthen the management of farmland, and improve the healthy productivity of cultivated land.
    Type of Medium: Online Resource
    ISSN: 2073-4395
    URL: Article
    DOI: 10.3390/agronomy12020478
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2607043-1
    SSG: 23
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  • 7
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    Circ-GALNT16 restrains colorectal cancer progression by enhancing the SUMOylation of hnRNPK
    Springer Science and Business Media LLC ; 2021
    In:  Journal of Experimental & Clinical Cancer Research Vol. 40, No. 1 ( 2021-12)
    Details
    In: Journal of Experimental & Clinical Cancer Research, Springer Science and Business Media LLC, Vol. 40, No. 1 ( 2021-12)
    Abstract: Recent studies have investigated the role of circular RNAs (circRNAs) as significant regulatory factors in multiple cancer progression. Nevertheless, the biological functions of circRNAs and the underlying mechanisms by which they regulate colorectal cancer (CRC) progression remain unclear. Methods A novel circRNA (circ-GALNT16) was identified by microarray and qRT-PCR. A series of in vitro and in vivo phenotype experiments were performed to investigate the role of circ-GALNT16 in CRC. The FISH, RNA pulldown assay, RIP assay, RNA sequencing, coimmunoprecipitation, and ChIP were performed to investigate the molecular mechanisms of circ-GALNT16 in CRC progression. Results Circ-GALNT16 was downregulated in CRC and was negatively correlated with poor prognosis. Circ-GALNT16 suppressed the proliferation and metastatic ability of CRC cells in vitro and in vivo . Mechanistically, circ-GALNT16 could bind to the KH3 domain of heterogeneous nuclear ribonucleoprotein K (hnRNPK), which promoted the SUMOylation of hnRNPK. Additionally, circ-GALNT16 could enhance the formation of the hnRNPK-p53 complex by facilitating the SUMOylation of hnRNPK. RNA sequencing assay identified serpin family E member 1 as the target gene of circ-GALNT16 at the transcriptional level. Rescue assays revealed that circ-GALNT16 regulated the expression of Serpine1 by inhibiting the deSUMOylation of hnRNPK mediated by SUMO-specific peptidase 2 and then regulating the sequence-specific DNA binding ability of the hnRNPK-p53 transcriptional complex. Conclusions Circ-GALNT16 suppressed CRC progression by inhibiting Serpine1 expression through regulating the sequence-specific DNA binding ability of the SENP2-mediated hnRNPK-p53 transcriptional complex and might function as a biomarker and therapeutic target for CRC.
    Type of Medium: Online Resource
    ISSN: 1756-9966
    URL: Article
    DOI: 10.1186/s13046-021-02074-7
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
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  • 8
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    CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer progression via promoting degradation of MOB1A to inhibit the Hippo pathway
    Springer Science and Business Media LLC ; 2022
    In:  Cell Death & Disease Vol. 13, No. 9 ( 2022-09-19)
    Details
    In: Cell Death & Disease, Springer Science and Business Media LLC, Vol. 13, No. 9 ( 2022-09-19)
    Abstract: Cancer-associated fibroblasts (CAFs) are the most abundant stromal components in the tumor microenvironment (TME) and closely involved in tumor progression. However, the precise biological functions and molecular mechanisms of CAFs in the TME have yet to be understood. Here, we demonstrate that WEE2-AS1 is highly expressed in the CAF-derived small extracellular vesicles (sEVs). Moreover, WEE2-AS1 is markedly higher in plasma sEVs of CRC patients than in healthy subjects and its high level predicts advanced pathological staging and poor survival. Then, we conducted a series of in vitro and in vivo experiments. Elevated expression of WEE2-AS1 in sEVs increases CRC cell proliferation in vitro. Importantly, aberrant CAF-sEVs WEE2-AS1 leads to tumor formation and progression in BALB/c nude mice and promotes AOM/DSS-induced tumorigenesis. Mechanistically, WEE2-AS1 functions as a modular scaffold for the MOB1A and E3 ubiquitin-protein ligase praja2 complexes, leading to MOB1A degradation via the ubiquitin-proteasome pathway. The Hippo pathway is then inhibited and more YAP are transported into the nucleus, where they activate downstream gene transcription. Together, our data reveal that CAF-sEVs WEE2-AS1 interacts with MOB1A, promotes degradation of MOB1A, inhibits the Hippo pathway, and facilitates the growth of CRC cells. Hence, exosomal WEE2-AS1 may be a promising therapeutic target and circulating biomarker for CRC diagnosis and prognosis.
    Type of Medium: Online Resource
    ISSN: 2041-4889
    URL: Article
    DOI: 10.1038/s41419-022-05240-7
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2541626-1
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  • 9
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    Long non-coding RNA Lnc-LALC facilitates colorectal cancer liver metastasis via epigenetically silencing LZTS1
    Springer Science and Business Media LLC ; 2021
    In:  Cell Death & Disease Vol. 12, No. 2 ( 2021-02-26)
    Details
    In: Cell Death & Disease, Springer Science and Business Media LLC, Vol. 12, No. 2 ( 2021-02-26)
    Abstract: Colorectal cancer (CRC) is one of the most common cancers around the world and endangers human health seriously. Liver metastasis is an important factor affecting the long-term prognosis of CRC and the specific mechanism of CRLM (colorectal cancer with liver metastasis) is not fully understood. LZTS1 has been found dysregulated in many cancers, especially in CRC. Theories suggested that hypermethylation of the promoter regions of LZTS1 was responsible for LZTS1 abnormal expression in multiple malignant tumors. Although the role of LZTS1 in CRC cell proliferation has been reported, its role in CRLM remains unclear. Numerous studies reported Long non-coding RNA (lncRNA) could regulate the gene expression level by regulating gene methylation status in many tumors. However, whether there were lncRNAs could change the methylation status of LZTS1 or not in CRLM was unknown. In this study, we aimed to investigate whether there are lncRNAs can regulate the expression of LZTS1 through affecting DNA methylation in CRLM. We found that upregulated Lnc-LALC in CRC was negatively correlated with LZTS1 expression, and Lnc-LALC could regulate LZTS1 expression in both mRNA and protein level in our study. Functionally, Lnc-LALC enhanced the CRC cells metastasis ability in vitro and vivo through inhibiting the expression of LZTS1 . Furthermore, the precise mechanisms exploration showed that lnc-LALC could recruit DNA methyltransferases (DNMTs) to the LZTS1 promoter by combining with Enhancer of zeste homolog 2(EZH2) and then altered the expression of LZTS1 via DNMTs-mediated DNA methylation. Collectively, our data demonstrated the important role of Lnc-LALC/ LZTS1 axis in CRLM development.
    Type of Medium: Online Resource
    ISSN: 2041-4889
    URL: Article
    DOI: 10.1038/s41419-021-03461-w
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
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  • 10
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    CircRNA circ_0124554 blocked the ubiquitination of AKT promoting the skip lymphovascular invasion on hepatic metastasis in colorectal cancer
    Springer Science and Business Media LLC ; 2021
    In:  Cell Death & Disease Vol. 12, No. 3 ( 2021-03-15)
    Details
    In: Cell Death & Disease, Springer Science and Business Media LLC, Vol. 12, No. 3 ( 2021-03-15)
    Abstract: Colorectal cancer (CRC) is the fourth most common cancer in men and the third most common cancer in women worldwide. The incidence and mortality of CRC was increasing rapidly in China. Lymph node-negative colorectal cancer patients with synchronous liver metastasis (LNLM1) was defined as “skip” lymph vascular invasion on hepatic metastasis, who presenting poor prognosis. We aiming to investigate the potential mechanism for the “skip” lymph vascular invasion on hepatic metastasis in colorectal cancer. The microarray was applied for screening the transcription landscape of circRNA in lymph node negative CRC patients with synchronous liver metastasis (LNLM1) or without liver metastasis (LNLM0). We identified the aberrant increased circRNA circ_0124554 (also entitled as circ-LNLM) in tumor tissues of LNLM1 patients comparing with either the tumor tissues of LNLM0 or adjacent tissues of LNLM1. Circ-LNLM1 expression was highly correlated with liver metastasis and vascular invasion. Ectopic expression of cytoplasmic located circ-LNLM could promote invasion of CRC cells and induced the liver metastasis in animal models through the direct binding with AKT. The phosphorylation of AKT (T308/S473) was activated due to the blocked ubiquitination site of Lys in 0-52aa peptide of circ-LNLM. Endogenous plasma expression of circ-LNLM induced poor prognosis of LNLM1 and could distinguish LNLM1 patients from LNLM0. In conclusion, the circ-LNLM blocked the ubiquitination of AKT could promote the early metastasis especially for the lymph node-negative colorectal cancer patients with synchronous liver metastasis. The circ-LNLM might be prognosis and diagnosis biomarker for LNLM1 patients.
    Type of Medium: Online Resource
    ISSN: 2041-4889
    URL: Article
    DOI: 10.1038/s41419-021-03565-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
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