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  • 1
    Online Resource
    Online Resource
    Risk factors of extrauterine growth restriction in very preterm infants with bronchopulmonary dysplasia: a multi-center study in China
    Springer Science and Business Media LLC ; 2022
    In:  BMC Pediatrics Vol. 22, No. 1 ( 2022-12)
    Details
    In: BMC Pediatrics, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-12)
    Abstract: Nutritional deficiency soon after birth is a risk factor of chronic lung disease (bronchopulmonary dysplasia, BPD). Afflicted infants are further prone to inadequate growth during hospitalization (extrauterine growth restriction, EUGR). This multi-center retrospective study investigated risk factors of EUGR, specifically in very preterm infants with BPD. Method Data of infants with BPD who were born less than 32 weeks gestation ( n  = 1010) were collected from 7 regions of China. All infants were non-small for gestational age at birth. Infants were characterized as EUGR or non-EUGR at 36 weeks gestation or discharge, or stratified by gestational age or birthweight. Logistic regression analysis was applied. Results In 65.5% of the population, the BPD was mild. Infants with severe BPD (8.3%) had the highest rate of EUGR (72.6%, P   〈  0.001). Groups stratified by gestational age did not differ in rates of EUGR, but the birthweight of the EUGR group was significantly lower than that of the non-EUGR ( P   〈  0.001). Birthweights of  〈  1000, 1000–1499, and ≥ 1500 g showed EUGR rates of 65.9%, 43.4%, and 23.8%, respectively ( P   〈  0.001). Overall, the independent risk factors of EUGR were: moderate-to-severe BPD, gestational hypertension, cesarean section, cumulative fasting time, time required to achieve 110 kcal/kg/d, and hemodynamically significant patent ductus arteriosus (hsPDA). Conclusion In very preterm infants with BPD, the lower the birthweight or the more severe the BPD, the greater the risk of EUGR. In those with hsPDA, or moderate-to-severe BPD, it is especially important to prevent EUGR through perinatal management, enteral nutrition, and nutritional strategies.
    Type of Medium: Online Resource
    ISSN: 1471-2431
    URL: Article
    DOI: 10.1186/s12887-022-03405-z
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2041342-7
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  • 2
    Online Resource
    Online Resource
    Case of amyloidosis cutis dyschromica with dermoscopy
    Wiley ; 2019
    In:  The Journal of Dermatology Vol. 46, No. 2 ( 2019-02)
    Details
    In: The Journal of Dermatology, Wiley, Vol. 46, No. 2 ( 2019-02)
    Type of Medium: Online Resource
    ISSN: 0385-2407 , 1346-8138
    URL: Issue
    URL: Article
    DOI: 10.1111/jde.2019.46.issue-2
    DOI: 10.1111/1346-8138.14593
    RVK:
    XA 53120
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2222121-9
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  • 3
    Online Resource
    Online Resource
    Photoprotective Effects of Cannabidiol against Ultraviolet-B-Induced DNA Damage and Autophagy in Human Keratinocyte Cells and Mouse Skin Tissue
    MDPI AG ; 2022
    In:  Molecules Vol. 27, No. 19 ( 2022-10-10), p. 6740-
    Details
    In: Molecules, MDPI AG, Vol. 27, No. 19 ( 2022-10-10), p. 6740-
    Abstract: Cannabidiol (CBD) has emerged as a phytocannabinoid with various beneficial effects for the skin, including anti-photoaging effects, but its mechanisms of action are not fully elucidated. The study assessed CBD’s photoprotective effects against acute ultraviolet B (UVB)-induced damage in HaCaT human keratinocyte cells and murine skin tissue. CBD (8 μM) alleviated UVB-induced cytotoxicity, apoptosis, and G2/M cell cycle arrest in HaCaT cells. The contents of γH2AX and cyclobutane pyrimidine dimers were decreased after CBD treatment. CBD reduced the production of reactive oxygen species and modulated the expression of antioxidant-related proteins such as nuclear factor erythroid 2-related factor 2 in UVB-stimulated HaCaT cells. Furthermore, CBD mitigated the UVB-induced cytotoxicity by activating autophagy. In addition, a cream containing 5% CBD showed effectiveness against UVB-induced photodamage in a murine model. The CBD cream improved the skin’s condition by lowering the photodamage scores, reducing abnormal skin proliferation, and decreasing expression of the inflammation-related protein cyclooxygenase-2 in UVB-irradiated skin tissue. These findings indicate that CBD might be beneficial in alleviating UVB-induced skin damage in humans. The photoprotective effects of CBD might be attributed to its modulatory effects on redox homeostasis and autophagy.
    Type of Medium: Online Resource
    ISSN: 1420-3049
    URL: Article
    DOI: 10.3390/molecules27196740
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2008644-1
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  • 4
    Online Resource
    Online Resource
    Port‐wine stains associated with large vestibular aqueduct syndrome caused by mutations in GNAQ and SLC26A4 genes: A case report
    Wiley ; 2020
    In:  The Journal of Dermatology Vol. 47, No. 1 ( 2020-01), p. 78-81
    Details
    In: The Journal of Dermatology, Wiley, Vol. 47, No. 1 ( 2020-01), p. 78-81
    Abstract: Port‐wine stains (PWS) are capillary malformations associated with mutation in the GNAQ (NM_000441.1) gene. Large vestibular aqueduct syndrome (LVAS), caused by mutation in the SLC26A4 (NM_002072) gene, is an inner ear malformation that can lead to hearing loss. To our knowledge, LVAS in PWS patients has never been reported. Here, we describe a case of a 9‐year‐old female patient diagnosed with PWS on the face and neck, coexisting with large vestibular aqueduct syndrome. Further analyses revealed a somatic mutation in GNAQ and a compound heterozygous mutation in the SLC26A4 gene. Some PWS patients have associated abnormalities, such as glaucoma and choroidal hemangioma, leptomeningeal angiomas and atrophy or hypertrophy of bone and soft tissue. We present here the first case that reveals the possibility that capillary malformations are associated with inner ear malformation. More case reports and further studies are needed to determine whether these conditions coexist in other patients.
    Type of Medium: Online Resource
    ISSN: 0385-2407 , 1346-8138
    URL: Issue
    URL: Article
    DOI: 10.1111/jde.v47.1
    DOI: 10.1111/1346-8138.15130
    RVK:
    XA 53120
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2222121-9
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  • 5
    Online Resource
    Online Resource
    Suppression of experimental abdominal aortic aneurysms in the mice by treatment with Ginkgo biloba extract (EGb 761)
    Elsevier BV ; 2013
    In:  Journal of Ethnopharmacology Vol. 150, No. 1 ( 2013-10), p. 308-315
    Details
    In: Journal of Ethnopharmacology, Elsevier BV, Vol. 150, No. 1 ( 2013-10), p. 308-315
    Type of Medium: Online Resource
    ISSN: 0378-8741
    URL: Article
    DOI: 10.1016/j.jep.2013.08.048
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2013
    detail.hit.zdb_id: 1491279-X
    SSG: 15,3
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  • 6
    Online Resource
    Online Resource
    Morphology-dependent bactericidal activities of Ag/CeO2 catalysts against Escherichia coli
    Elsevier BV ; 2014
    In:  Journal of Inorganic Biochemistry Vol. 135 ( 2014-06), p. 45-53
    Details
    In: Journal of Inorganic Biochemistry, Elsevier BV, Vol. 135 ( 2014-06), p. 45-53
    Type of Medium: Online Resource
    ISSN: 0162-0134
    URL: Article
    DOI: 10.1016/j.jinorgbio.2014.02.016
    RVK:
    VA 5310
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2014
    detail.hit.zdb_id: 1491314-8
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    Sanshool improves UVB-induced skin photodamage by targeting JAK2/STAT3-dependent autophagy
    Springer Science and Business Media LLC ; 2019
    In:  Cell Death & Disease Vol. 10, No. 1 ( 2019-01-08)
    Details
    In: Cell Death & Disease, Springer Science and Business Media LLC, Vol. 10, No. 1 ( 2019-01-08)
    Abstract: Ultraviolet radiation is markedly increased because of pollution and the depletion of the stratospheric ozone layer. Excessive exposure to sunlight can negatively affect the skin, resulting in sunburn, photo-aging, or skin cancer. In this study, we first determined the photoprotective effect of sanshool, a major component in Zanthoxylum bungeanum , on UVB-irradiated responses in human dermal fibroblasts (HDFs) and nude mouse. We found that sanshool treatment can protect cells against the effects of UVB irradiation by (i) increasing cell viability, (ii) inhibiting MMP expression, and (iii) inducing autophagy. We also used the recombinant CSF2 or anti-CSF2 antibody co-cultured with human dermal fibroblasts (HDFs) and found that CSF2 contributes to sanshool-induced autophagy. Sanshool hindered the UVB-induced activation of JAK2-STAT3 signaling in HDFs, thereby inhibiting the expression of MMPs and activation of autophagic flux. Exposure of the dorsal skin of hairless mice to UVB radiation and subsequent topical application of sanshool delayed the progression of skin inflammation, leading to autophagy and inhibiting the activation of JAK2-STAT3 signaling. These results provide a basis for the study of the photoprotective effect of sanshool and suggest that it can be potentially used as an agent against UVB-induced skin damage in humans.
    Type of Medium: Online Resource
    ISSN: 2041-4889
    URL: Article
    DOI: 10.1038/s41419-018-1261-y
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 2541626-1
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  • 8
    Online Resource
    Online Resource
    Influence of functional groups on toxicity of carbon nanomaterials
    Copernicus GmbH ; 2019
    In:  Atmospheric Chemistry and Physics Vol. 19, No. 12 ( 2019-06-24), p. 8175-8187
    Details
    In: Atmospheric Chemistry and Physics, Copernicus GmbH, Vol. 19, No. 12 ( 2019-06-24), p. 8175-8187
    Abstract: Abstract. It has been recognized that carbon nanomaterials and soot particles are toxic for human health, but the influence of functionalization on their toxicity as well as the evolution of the toxicity of carbon nanomaterials due to chemical aging in the atmosphere is still controversial. In the current study, the oxidation potential measured by dithiothreitol (DTT) decay rate and the cytotoxicity to murine macrophage cells of different functionalized carbon nanomaterials were investigated to understand the role of functionalization in their toxicities. The DTT decay rates of special black 4A (SB4A), graphene, graphene oxide, single-walled carbon nanotubes (SWCNTs), SWCNT-OH and SWCNT-COOH were 45.9±3.0, 58.5±6.6, 160.7±21.7, 38.9±8.9, 57.0±7.2 and 36.7±0.2 pmol min−1 µg−1, respectively. Epoxide was found to be mainly responsible for the highest DTT decay rate of graphene oxide compared to other carbon nanomaterials based on comprehensive characterizations. Both carboxylation and hydroxylation showed little influence on the oxidation potential of carbon nanomaterials, while epoxidation contributes to the enhancement of oxidation potential. All these carbon nanomaterials were toxic to the murine J774 cell line. However, oxidized carbon nanomaterials (graphene oxide, SWCNT-OH and SWCNT-COOH) showed weaker cytotoxicity to the J774 cell line compared to the corresponding control sample as far as the metabolic activity was considered and stronger cytotoxicity to the J774 cell line regarding the membrane integrity and DNA incorporation. These results imply that epoxidation might enhance the oxidation potential of carbon nanomaterials.
    Type of Medium: Online Resource
    ISSN: 1680-7324
    URL: Article
    URL: Article
    DOI: 10.5194/acp-19-8175-2019
    DOI: 10.5194/acp-19-8175-2019-supplement
    Language: English
    Publisher: Copernicus GmbH
    Publication Date: 2019
    detail.hit.zdb_id: 2092549-9
    detail.hit.zdb_id: 2069847-1
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  • 9
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    Online Resource
    Guillain-Barré syndrome in southern China: retrospective analysis of hospitalised patients from 14 provinces in the area south of the Huaihe River
    BMJ ; 2018
    In:  Journal of Neurology, Neurosurgery & Psychiatry Vol. 89, No. 6 ( 2018-06), p. 618-626
    Details
    In: Journal of Neurology, Neurosurgery & Psychiatry, BMJ, Vol. 89, No. 6 ( 2018-06), p. 618-626
    Abstract: The clinical and epidemiological profiles of Guillain-Barré syndrome (GBS) in southern China have yet to be fully recognised. We aimed to investigate the subtypes of GBS in southern China, compare the clinical features of demyelinating form with that of axonal form and test whether preceding infections and age have influence on the clinical phenotype, disease course and severity of GBS. Methods Medical records of patients with a diagnosis of GBS admitted to 31 tertiary hospitals, located in 14 provinces in southern China, from 1 January 2013 to 30 September 2016, were collected and retrospectively reviewed. Results Finally. 1056 patients, including 887 classic GBS and 169 variants, were enrolled. The 661 classic patients with available electromyographic data were grouped as having acute inflammatory demyelinating polyneuropathy (AIDP, 49.0%), acute motor axonal neuropathy (AMAN, 18.8%), inexcitable (0.9%) and equivocal (31.3%). In contrast to AIDP, patients with AMAN were characterised by earlier nadir (P=0.000), higher Hughes score at nadir (P=0.003) and at discharge (P=0.000). Preceding upper respiratory infections were identified in 369 (34.9%) patients, who were more inclined to develop AIDP (P = 0.000) and Miller-Fisher syndrome (P = 0.027), whereas gastrointestinal infection were found in 89 (8.4%) patients, who were more prone to develop AMAN (P=0.000), with more severe illness (P=0.001) and longer hospital stay (P=0.009). Children (≤15 years) and the elderly (≥56 years) were more severe at nadir, the elderly had the longest hospital stay (P=0.023). Conclusion AIDP is the predominant form in southern China, which is different from data of northern China. The different subtypes, preceding infection and age of onset can partially determine the disease progression, severity and short-term recovery speed of GBS. Clinical trial registration ChiCTR-RRC-17014152.
    Type of Medium: Online Resource
    ISSN: 0022-3050 , 1468-330X
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.1136/jnnp-2017-316930
    DOI: 10.1136/jnnp-2017-316930.supp1
    DOI: 10.1136/jnnp-2017-316930.supp2
    RVK:
    XA 10000
    Language: English
    Publisher: BMJ
    Publication Date: 2018
    detail.hit.zdb_id: 1480429-3
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  • 10
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    Online Resource
    Sohlh1 and Lhx8 are prominent biomarkers to estimate the primordial follicle pool in mice
    Springer Science and Business Media LLC ; 2023
    In:  Reproductive Biology and Endocrinology Vol. 21, No. 1 ( 2023-05-16)
    Details
    In: Reproductive Biology and Endocrinology, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2023-05-16)
    Abstract: Efficient evaluation of the primordial follicle pool (PFP) of mammalian models is an essential subject in biomedical research relating to ovarian physiology and pathogenesis. Our recent study has identified a gene signature including Sohlh1 , Nobox , Lhx8 , Tbpl2 , Stk31 , Padi6 , and Vrtn strongly correlated with ovarian reserve by using bioinformatics analysis. Aimed to investigate the validity of these candidate biomarkers for evaluating the PFP, we utilized an OR comparison model to decode the relationship between the numbers of PFP and candidate biomarkers in the present study. Our results suggest that these biomarkers Sohlh1, Nobox, Lhx8, Tbpl2, Stk31, Padi6 , and Vrtn possess independent potential to evaluate the number of the PFP. And the combination of Sohlh1 and Lhx8 can be used as the optimal biomarkers for rapid assessment of the PFP in the murine ovary. Our findings provide a new perspective for evaluating the PFP of the ovary in animal studies and the clinic.
    Type of Medium: Online Resource
    ISSN: 1477-7827
    URL: Article
    DOI: 10.1186/s12958-023-01097-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2119215-7
    SSG: 12
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