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  • SAGE Publications  (17)
  • Wang, Lei  (17)
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  • SAGE Publications  (17)
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  • 1
    Online Resource
    Online Resource
    Clinicopathological, Immunohistochemical, and Molecular Characteristics of Pigmented Microcystic Chromophobe Renal Cell Carcinoma with Favorable Prognosis
    SAGE Publications ; 2024
    In:  International Journal of Surgical Pathology
    Details
    In: International Journal of Surgical Pathology, SAGE Publications
    Abstract: Background. Pigmented microcystic chromophobe renal cell carcinoma (RCC) is a subtype of chromophobe RCC. Its distinct histopathologic features are microcystic and microtubular pattern, pigmentation, and microcalcifications. Pigmented microcystic chromophobe RCC has ultrastructure, immunophenotypic structure, and molecular results similar to chromophobe RCC. Methods. We report five tumors of pigmented microcystic chromophobe RCC. Morphological observation and immunohistochemical examination were performed, and clinical and molecular features were analyzed. Results. Microscopically, all five tumors showed brown pigmentation, microcystic, and tubular cystic structures, one tumor presented microscopic calcifications. All tumors were positive for EMA, AE1/AE3, PAX8, KRT7, KIT (CD117), claudin 7, KRT8, and E-cadherin, and three tumors expressed P504S. All tumors were negative for vimentin, CA9, KRT20, TFE3, TFEB, Melan-A, HMB45, FH, SDHB, and GATA3. Ki-67 index varied from less than 1% to 2%. In three tumors, next-generation sequencing of the 688 gene was performed, the results found gene variants with potential clinical significance such as JMJD1C, MYCL, TP53, PI3KCA, KRAS, APC, GLI1, LRRK2, and gene variants with unclear clinical significance such as NTRK1 and RAD50; All patients remained alive over a follow-up period of 8–46 months without tumor recurrence and sarcomatoid transformation. Conclusions. Pigmented microcystic chromophobe RCC has a relatively benign biological behavior, and distant metastases and sarcomatoid transformation are rare. This overview of five additional tumors of pigmented microcystic chromophobe RCC offers further insight into this special subtype of chromophobe RCC.
    Type of Medium: Online Resource
    ISSN: 1066-8969 , 1940-2465
    URL: Article
    DOI: 10.1177/10668969231217632
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2024
    detail.hit.zdb_id: 2070102-0
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  • 2
    Online Resource
    Online Resource
    Stem Cells from Human Exfoliated Deciduous teeth Promote Hair Regeneration in Mouse
    SAGE Publications ; 2021
    In:  Cell Transplantation Vol. 30 ( 2021-01-01), p. 096368972110429-
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 30 ( 2021-01-01), p. 096368972110429-
    Abstract: Stem cells in different types may interact with each other to maintain homeostasis or growth and the interactions are complicated and extensive. There is increasing evidence that mesenchymal-epithelial interactions in early morphogenesis stages of both tooth and hair follicles show many similarities. In order to explore whether stem cells from one tissue could interact with cells from another tissue, a series of experiments were carried out. Here we successfully extracted and identified stem cells from human exfoliated deciduous teeth (SHED) of 8–12 years old kids, and then found that SHED could promote hair regeneration in a mouse model. In vitro, SHED shortened the hair regeneration cycle and promoted the proliferation and aggregation of dermal cells. In vivo, when SHED and skin cells of C57 mice were subcutaneously co-transplanted to nude mice, more hair was formed than skin cells without SHED. To further explore the molecular mechanism, epidermal and dermal cells were freshly extracted and co-cultured with SHED. Then several signaling molecules in hair follicle regeneration were detected and we found that the expression of Sonic Hedgehog (Shh) and Glioma-associated oncogene 1 (Gli1) was up-regulated. It seems that SHED may boost the prosperity of hairs by increase Shh/Gli1 pathway, which brings new perspectives in tissue engineering and damaged tissue repairing.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.1177/09636897211042927
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2020466-8
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  • 3
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    Online Resource
    Transcriptome Analysis of Induced Pluripotent Stem Cell (iPSC)-derived Pancreatic β-like Cell Differentiation
    SAGE Publications ; 2017
    In:  Cell Transplantation Vol. 26, No. 8 ( 2017-08), p. 1380-1391
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 26, No. 8 ( 2017-08), p. 1380-1391
    Abstract: Diabetes affects millions of people worldwide, and β-cell replacement is one of the promising new strategies for treatment. Induced pluripotent stem cells (iPSCs) can differentiate into any cell type, including pancreatic β cells, providing a potential treatment for diabetes. However, the molecular mechanisms underlying the differentiation of iPSC-derived β cells have not yet been fully elucidated. Here, we generated pancreatic β-like cells from mouse iPSCs using a 3-step protocol and performed deep RNA sequencing to get a transcriptional landscape of iPSC-derived pancreatic β-like cells during the selective differentiation period. We then focused on the differentially expressed genes (DEGs) during the time course of the differentiation period, and these genes underwent Gene Ontology annotation and Kyoto Encyclopedia of Genes and Genomes pathway analysis. In addition, gene-act networks were constructed for these DEGs, and the expression of pivotal genes detected by quantitative real-time polymerase chain reaction was well correlated with RNA sequence (RNA-seq). Overall, our study provides valuable information regarding the transcriptome changes in β cells derived from iPSCs during differentiation, elucidates the biological process and pathways underlying β-cell differentiation, and promotes the identification and functional analysis of potential genes that could be used for improving functional β-cell generation from iPSCs.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.1177/0963689717720281
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2020466-8
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  • 4
    Online Resource
    Online Resource
    Transcriptome analysis of the induced pluripotent stem cell (iPSC)-derived pancreatic β-like cell differentiation
    SAGE Publications ; 2017
    In:  Cell Transplantation
    Details
    In: Cell Transplantation, SAGE Publications
    Type of Medium: Online Resource
    ISSN: 0963-6897
    URL: Article
    DOI: 10.3727/096368917X695399
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2020466-8
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  • 5
    Online Resource
    Online Resource
    Serum prolactin levels, plasma risperidone levels, polymorphism of cytochrome P450 2D6 and clinical response in patients with schizophrenia
    SAGE Publications ; 2007
    In:  Journal of Psychopharmacology Vol. 21, No. 8 ( 2007-11), p. 837-842
    Details
    In: Journal of Psychopharmacology, SAGE Publications, Vol. 21, No. 8 ( 2007-11), p. 837-842
    Abstract: The object of this study is to assess 1) the relationship between plasma antipsychotic drug concentration, serum prolactin levels and the clinical efficacy of risperidone, 2) the relationship between the CYP2D6 polymorphisms and metabolizing of risperidone and 3) the role of 9-hydroxyrisperidone in elevating prolactin levels. One-hundred and eighteen Chinese schizophrenia patients (40 males, 78 females, age 15—60 years) were given risperidone at dosages ranging from 2—8 mg/day for 8 weeks. Clinical efficacy was determined using the Brief Psychiatric Rating Scores (BPRS). Serum prolactin levels were assayed before and after the 8 week treatment and plasma risperidone and 9-hydroxyrisperidone levels were also measured at the end of the 8-week treatment. The results showed there was no significant correlation between the concentration of active moiety and clinical response. Risperidone treatment significantly increased serum prolactin levels. Furthermore, changes of prolactin levels were not correlated with the clinical response. For the risperidone/ 9-hydroxyrisperidone ratio, there was a statistically significant difference among the CYP2D6*1/*1, *1/*10, *10/*10 genotypes (Kruskal—Wallis test, p = 0.012). No significant differences were found in the concentration of 9-hydroxyrisperidone and active moiety among the genotypes. In addition, the concentration of 9-hydroxyrisperidone was not significantly correlated with the increase of serum prolactin. In conclusion, our study has, for the first time, produced evidence that in Chinese schizophrenic patients, the metabolism of risperidone is dependent on CYP2D6. Neither changes in serum prolactin levels nor plasma concentration of active moiety were significantly correlated with clinical efficacy of risperidone. 9-hydroxyrisperidone may not play a predominant role in elevating serum prolactin level.
    Type of Medium: Online Resource
    ISSN: 0269-8811 , 1461-7285
    URL: Article
    DOI: 10.1177/0269881107077357
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2028926-1
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  • 6
    Online Resource
    Online Resource
    Immune checkpoint inhibitors plus chemotherapy in patients with locally advanced or metastatic pulmonary sarcomatoid carcinoma: a multicentric real-world study
    SAGE Publications ; 2022
    In:  Therapeutic Advances in Medical Oncology Vol. 14 ( 2022-01), p. 175883592211367-
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 14 ( 2022-01), p. 175883592211367-
    Abstract: Immune checkpoint inhibitors (ICIs) have demonstrated promising efficacy as monotherapy in patients with pulmonary sarcomatoid carcinoma (PSC). We performed the current multi-institutional, real-world study to assess the efficacy of ICIs plus chemotherapy in patients with PSC. Methods: All consecutive patients with locally advanced or metastatic PSC from three centers treated with ICIs between January 2018 and July 2021 were enrolled. Programmed death ligand 1 (PD-L1) expression was stained and evaluated using immunohistochemical with 22C3. Single-cell RNA sequencing (scRNA-seq) was performed in two patients with PSC and two patients with adenocarcinoma to understand the cell-type-specific transcriptome landscape of cancer cells and tumor microenvironment (TME) of PSC. Results: A cohort of 42 PSC patients was identified. In the overall population, the objective response rate (ORR) was 73.8%, median progression-free survival (mPFS) was 10.3 months and median overall survival was not reached and 2-year survival rate was 51.2%. For 34 treatment-naïve patients who received first-line ICIs plus chemotherapy, the ORR was 70.6%, mPFS was 10.3 months and 2-year survival rate was 57.8%. In patients with PD-L1 tumor proportion score (TPS)  〈  1%, 1–49%, and ⩾50%, the ORR was 33.3%, 72.7%, and 85.7% and mPFS was 6.0, 6.7, and 10.3 months, respectively. Notably, two patients with transformed PSC from lung adenocarcinoma after epidermal growth factor receptor-tyrosine kinase inhibitor treatment also responded well to ICIs plus chemotherapy. scRNA-seq revealed immune-cell-inflamed TME, lower intratumoral heterogeneity, and activated immune response pathway in PSC. Conclusions: Our study demonstrated remarkable efficacy of ICIs plus chemotherapy as first-line therapy for patient with locally advanced or metastatic PSC.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/17588359221136759
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2503443-1
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  • 7
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    Six-month results of stenting of the femoropopliteal artery and predictive value of interleukin-6: Comparison with high-sensitivity C-reactive protein
    SAGE Publications ; 2020
    In:  Vascular Vol. 28, No. 6 ( 2020-12), p. 715-721
    Details
    In: Vascular, SAGE Publications, Vol. 28, No. 6 ( 2020-12), p. 715-721
    Abstract: To determine the association of pre- and postinterventional serum levels of interleukin-6 and high-sensitivity C-reactive protein at the six-month evaluation of restenosis after stenting of the femoropopliteal artery. Methods Sixty-eight consecutive patients with steno-occlusive femoropopliteal artery disease of Rutherford category III or IV who underwent stent implantation were included. Six-month patency was evaluated with color-coded duplex ultrasound. The association of in-stent restenosis with interleukin-6 and high-sensitivity C-reactive protein levels at baseline, and 24-h postintervention was assessed with a multivariate logistic regression analysis. Results In-stent restenosis was found in 15 patients (22.1%) within six months. Interleukin-6 and high-sensitivity C-reactive protein levels were significantly increased at 24-h postintervention compared to their preintervention values ( p  〈  0.001 and p = 0.002, respectively). Interleukin-6 values at baseline (odds ratio, 1.11; 95% confidence interval: 1.00, 1.23; p = 0.044) and 24-h postintervention (odds ratio, 1.04; 95% confidence interval: 1.02, 1.06; p  〈  0.001) were independently associated with six-month in-stent restenosis. Twenty-four-hour postinterventional high-sensitivity C-reactive protein levels were also found to be related to restenosis (odds ratio, 1.15; 95% confidence interval: 1.04, 1.26; p = 0.006), but high-sensitivity C-reactive protein levels at baseline did not show an independent association with in-stent restenosis (odds ratio, 0.57; 95% confidence interval: 0.35, 1.80; p = 0.667). Smoking, diabetes mellitus, and cumulative stent length were other parameters associated with an increased risk for in-stent restenosis. Conclusions Femoropopliteal artery angioplasty with stent placement induces an inflammatory response. Interleukin-6 is a powerful independent predictor of intermediate-term outcomes for stenting of the femoropopliteal artery, suggesting that its predictive value may be superior to that of high-sensitivity C-reactive protein.
    Type of Medium: Online Resource
    ISSN: 1708-5381 , 1708-539X
    URL: Article
    DOI: 10.1177/1708538120921005
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2143006-8
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  • 8
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    A generalized control scheme for system uncertainty estimation and cancellation
    SAGE Publications ; 2021
    In:  Transactions of the Institute of Measurement and Control Vol. 43, No. 13 ( 2021-09), p. 2921-2933
    Details
    In: Transactions of the Institute of Measurement and Control, SAGE Publications, Vol. 43, No. 13 ( 2021-09), p. 2921-2933
    Abstract: This paper addresses the control of a continuous-time system with possibly large uncertainty of unknown internal dynamics or external disturbance. A novel control scheme is proposed to estimate and cancel the system uncertainty effectively so as to enhance disturbance rejection (DR) performance. Unlike asymptotic analysis with infinite gain in the literature, the estimation transient analysis is carried out for the proposed scheme with a finite estimator gain and the precise error formulas are derived, based on a classical low-order plant description. The control performance associated with a realizable gain is quantified by tight bounds with respect to the ideal case, which enables easy parameter tuning. The necessary and sufficient condition for the internal stability of the control system is established, along with a D-decomposition method for determining the complete set of the gain intervals that could internally stabilize the plant. In the presence of measurement noise, a low-pass filter is introduced to attenuate its adverse effect. Simulations and semi-realistic experiments are performed to demonstrate the effectiveness of the proposed scheme, which shows evident improvement on DR performance over the well-known active DR control.
    Type of Medium: Online Resource
    ISSN: 0142-3312 , 1477-0369
    URL: Article
    DOI: 10.1177/01423312211010509
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2025882-3
    SSG: 3,2
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  • 9
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    Effect of axial slot casing treatment on a counter-rotating axial-flow compressor aerodynamic performance and stability
    SAGE Publications ; 2023
    In:  Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering Vol. 237, No. 5 ( 2023-04), p. 1185-1198
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering, SAGE Publications, Vol. 237, No. 5 ( 2023-04), p. 1185-1198
    Abstract: Counter-rotating axial-flow compressor (CRAC) technology is an important technical way to improve the thrust-to-weight ratio of aero-engines. To explore the stall margin improvement potential of axial slot casing treatment (ASCT) in the CRAC, a two-stage CRAC is selected to investigate the influence of axial position and radial deflection angle of slots on the stabilization capability of ASCT by numerical method. The paper also revealed the stability expansion mechanism of ASCT in the CRAC and the effect of casing treatment on the rotor/rotor interference effect between the front and rear rotors. Results show that the axial position of slots has little effect on stall margin improvement capacity of ASCT but has a great influence on peak efficiency. Increasing the radial deflection angle of slots to further improve the stabilization ability of ASCT is not remarkable, but it is beneficial to decline the efficiency penalty. The suppression of tip leakage flow by slots and the transport of low-energy fluid near the blade tip can delay the occurrence of the stall, and the maximum stall margin is improved by about 10.75%. Besides, the ASCT decreases the unsteady interference effect between the rotors and inhibits the potential flow effect of the downstream blade passage and improves the inlet flow field quality of the rear rotors.
    Type of Medium: Online Resource
    ISSN: 0954-4100 , 2041-3025
    URL: Article
    DOI: 10.1177/09544100221119030
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2032759-6
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  • 10
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    Regulation of Th1/Th2 and Th17/Treg by pDC/mDC imbalance in primary immune thrombocytopenia
    SAGE Publications ; 2021
    In:  Experimental Biology and Medicine Vol. 246, No. 15 ( 2021-08), p. 1688-1697
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 246, No. 15 ( 2021-08), p. 1688-1697
    Abstract: This study investigates the regulatory effect of plasmacytoid dendritic cells (pDC)/myeloid dendritic cells (mDC) imbalance on balance of Th1/Th2 and Th17/Treg in primary immune thrombocytopenia (ITP). A total of 30 untreated ITP patients and 20 healthy controls were recruited. Compared with healthy control, the pDC proportion of ITP patients was significantly reduced ( P = 0.004), while the mDC proportion was not significantly changed ( P = 0.681), resulting in a decrease in the pDC/mDC ratio ( P = 0.001). Additionally, compared with controls, serum levels of interleukin (IL)-6, IL-12, and IL-23 were increased in ITP patients ( P  〈  0.001), and mRNA levels of IL-12p40, IL-12p35, and IL-23p19 were also increased ( P =0.014, P = 0.043, P  〈  0.001). Compared with the healthy control, the proportion of Th1 and Th17 cells in ITP patients increased ( P = 0.001, P = 0.031). Serum levels of interferon gamma (IFN-γ) and IL-17 in ITP patients also increased ( P = 0.025, P = 0.005). Furthermore, T-bet and RORγt mRNA levels were increased in peripheral blood of ITP patients ( P = 0.018, P  〈  0.001). Correspondingly, the proportion of Th2 and Treg cells decreased ( P = 0.007, P  〈  0.001), along with a decrease in serum IL-4 and transforming growth factor beta (TGF-β) ( P = 0.028, P = 0.042), and an increase in GATA-3 mRNA ( P  〈  0.001). However, there was no significant difference in Foxp3 mRNA levels ( P = 0.587). Pearson correlation analysis showed that the proportion of total dendritic cells (DCs) was positively correlated with IL-12 ( r = 0.526, P = 0.003) and IL-23 ( r = 0.501, P = 0.005) in ITP patients. Th1/Th2 ratio, IFN-γ, and IL-12 levels were negatively correlated with platelet counts ( r = −0.494, P = 0.009; r = –0.415, P = 0.028; r = –0.492, P = 0.032). However, IL-23 was positively correlated with IL-17 ( r = 0.489, P = 0.006) and negatively correlated with platelet count ( r = –0.564, P = 0.001). The ratio of IL-6 and Th17 cells was negatively correlated with platelet count ( r = –0.443, P = 0.014; r = –0.471, P = 0.011). The imbalance of pDC/mDC and the increase of IL-6, IL-12, and IL-23 lead to the increased differentiation of CD4+ T cells into Th1 and Th17 cells, which might be the important mechanisms underlying the imbalance of Th1/Th2 and Th17/Treg in ITP patients.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1177/15353702211009787
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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