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  • SAGE Publications  (4)
  • Wang, Kai  (4)
  • 2015-2019  (4)
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  • SAGE Publications  (4)
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  • 2015-2019  (4)
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  • 1
    In: Journal of Bioactive and Compatible Polymers, SAGE Publications, Vol. 30, No. 2 ( 2015-03), p. 209-221
    Abstract: Poly(3-hydroxybutyrate-co-4-hydroxybutyrate), poly(ε-caprolactone), and poly(1actide-co-glycolide) films were prepared by solution casting and electrospinning. The degradability of cast films was evaluated in vitro and in vivo by recording the weight remaining, observing the morphology, and measuring change in molecular weight and M w / M n polydispersity. In addition, cell proliferation on electrospun films was tested by MTT assay, and cell infiltration into electrospun films was assessed through subcutaneous implantation in rats. By analyzing data obtained from these tests, we discovered that the degradation rates of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) copolymers were between those of poly(ε-caprolactone) and poly(1actide-co-glycolide) and could be controlled by adjusting 4-hydroxybutyrate content. Moreover, tissue responses to materials made from poly(3-hydroxybutyrate-co-4-hydroxybutyrate) were milder compared with those elicited by poly(ε-caprolactone) and poly(1actide-co-glycolide), and poly(3-hydroxybutyrate-co-4-hydroxybutyrate) films exhibited a good and moderate cell infiltration. Therefore, our data demonstrate that poly(3-hydroxybutyrate-co-4-hydroxybutyrate) copolymers are promising candidates for the construction of scaffolds designed for various types of tissue regeneration with special biodegradability requirements.
    Type of Medium: Online Resource
    ISSN: 0883-9115 , 1530-8030
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2073790-7
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2018
    In:  Journal of Bioactive and Compatible Polymers Vol. 33, No. 2 ( 2018-03), p. 119-133
    In: Journal of Bioactive and Compatible Polymers, SAGE Publications, Vol. 33, No. 2 ( 2018-03), p. 119-133
    Abstract: Biodegradable pH-sensitive amphiphilic block polymer (mPEG-Hyde-PLGA) was synthesized via ring-opening polymerization, initiated from a hydrazone-containing macro-initiator. In this way, a pH-sensitive hydrazone bond was inserted into the backbone of block copolymer, linking hydrophilic poly(ethylene glycol) segment and hydrophobic poly(lactic-co-glycolic acid) segment. The copolymer self-assembled to form stable micelles with mean diameters below 100 nm and served as a drug delivery system for doxorubicin, with drug loading content of 5.3%. pH sensitivity of the hydrazone-containing micelles was investigated by changes in diameter and size distribution observed by dynamic light scattering measurements when the micelles were encountered to acidic medium. Small pieces and larger aggregates were found by transmission electron microscopy resulting from the disassociation of the micelles in acidic conditions. It was also noted that doxorubicin release from the pH-sensitive micelles is significantly faster at pH 4.0 and pH 5.0 compared to pH 7.4, while almost no difference was detected in the case of pH non-sensitive micelles. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays on HepG-2 and MCF-7 cells revealed that doxorubicin-loaded pH-sensitive micelles had higher antitumor activity than pH-insensitive ones. This pH-sensitive drug delivery system based on hydrazone-containing block copolymer has been proved as a promising drug formulation for cancer therapy.
    Type of Medium: Online Resource
    ISSN: 0883-9115 , 1530-8030
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2073790-7
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  • 3
    Online Resource
    Online Resource
    SAGE Publications ; 2017
    In:  The Journal of Vascular Access Vol. 18, No. 1 ( 2017-01), p. 1-2
    In: The Journal of Vascular Access, SAGE Publications, Vol. 18, No. 1 ( 2017-01), p. 1-2
    Abstract: Peripherally inserted central catheters (PICCs) have been placed through the peripheral veins, and the best location for the tip of the PICCs is the lower third of the superior vena cava (SVC) and cavo-atrial junction. PICCs are commonly used in intravenous administration, parenteral nutrition therapy, chemotherapy, as well as in critical care units. The success rates in venipuncture are enhanced when ultrasonographic guides are used by the bedside PICC teams. There have been few reports of PICCs placed in super elderly patients with permanent cardiac pacemakers. We share a case of two successful PICC insertions in a 97-year-old patient with bilateral pacemaker placement, that have not been reported previously.
    Type of Medium: Online Resource
    ISSN: 1129-7298 , 1724-6032
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2079292-X
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  • 4
    Online Resource
    Online Resource
    SAGE Publications ; 2019
    In:  Advances in Mechanical Engineering Vol. 11, No. 6 ( 2019-06), p. 168781401985426-
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 11, No. 6 ( 2019-06), p. 168781401985426-
    Abstract: To improve the accuracy of road safety evaluation, this article presents a method to calculate the average crash probability for highway sections based on fault tree and energy method. First, the average crash probability of sections was formulated based on fault tree theory, taking lateral instability, rollover, and rear-end crash into account. Second, an instability factor, which described the extent of steering instability and tire sideslip, was proposed based on energy method. Thereafter, the relationships between the instability factor and probability of lateral instability crash, the load transfer ratio and probability of rollover crash, the available sight distance and probability of rear-end crash were investigated. Then, the driver–vehicle–road multi-body dynamics model was developed based on the three-dimensional alignments of Ning-Luo Expressway using CarSim, the dynamics indexes such as lateral velocity, wheel vertical load were obtained, and the average crash probability of each section was calculated. Finally, the correlation between average crash probability and the average number of accidents was analyzed to validate the accuracy of the proposed method. Results reveal that the proposed method can improve the accuracy of evaluation results, compared with existing methods, thus providing theoretical basis for black spot identification of both design phase and in-service highways.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2501620-9
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