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  • 1
    In: Hypertension Research, Springer Science and Business Media LLC
    Abstract: Not only systolic blood pressure (SBP) but also diastolic blood pressure (DBP) increases the risk of recurrence in the short- or long-term outcomes of stroke. The interaction between DBP and antiplatelet treatment for China stroke patients is unclear. This multicenter, observational cohort study included 2976 minor ischemic stroke patients. Patients accepted single antiplatelet therapy (SAPT) or dual antiplatelet therapy (DAPT) after arrival, and baseline DBP levels were trichotomized into 〈 90 mmHg, 90–110 mmHg and ≥110 mmHg. We explore the interaction effect between antiplatelet therapy and DBP on 90-days composite vascular events. A total of 257 (8.6%) patients reached a composite vascular event during follow-up. The interaction term between DBP levels and treatment group (SAPT vs. DAPT) was significant ( P for interaction = 0.013). DAPT’s adjusted HR for composite events in patients with DBP between 90 and 110 mmHg was 0.56 (95% confidence interval, 0.36 0.88; P  = 0.011) and DBP ≥ 110 mmHg was 4.35 (95% confidence interval, 1.11–19.94; P  = 0.046). The association between treatment and DBP was still consistent after propensity score matching of the baseline characteristics. The interaction term of DBP ×  treatment was not significant for the safety outcomes of severe bleeding ( P for interaction = 0.301) or hemorrhage stroke ( P for interaction = 0.831). In this cohort study based on the real world, patients with a DBP between 90 and 110 mmHg received a greater benefit from 90 days of DAPT than those with lower and higher baseline DBP. REGISTRATION: ( https://www.chictr.org.cn ; Unique identifier: ChiCTR1900025214)
    Type of Medium: Online Resource
    ISSN: 0916-9636 , 1348-4214
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2110941-2
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  • 2
    In: Cardiovascular Diabetology, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2023-04-19)
    Abstract: The triglyceride-glucose (TyG) index, a simple measure of insulin resistance, is associated with intracranial atherosclerosis (ICAS) and stroke. In hypertensive populations, this association may be pronounced. The aim was to investigate the relationship between TyG and symptomatic intracranial atherosclerosis (sICAS) and recurrence risk in ischemic stroke patients with hypertension. Methods This prospective, multicenter cohort study included patients with acute minor ischemic stroke with a preadmission diagnosis of hypertension from September 2019 to November 2021 with a 3-month follow-up. The presence of sICAS was determined by a combination of clinical manifestations, the location of the infarction, and the corresponding artery with moderate-to-severe stenosis. ICAS burden was determined by the degree and number of ICAS occurrences. Fasting blood glucose (FBG) and triglyceride (TG) were measured to calculate TyG. The main outcome was ischemic stroke recurrence during the 90-day follow-up. Multivariate regression models were used to explore the association of TyG, sICAS, and ICAS burden with stroke recurrence. Results There were 1281 patients with a mean age of 61.6 ± 11.6 years; 70.1% were male, and 26.4% were diagnosed with sICAS. There were 117 patients who experienced stroke recurrence during follow-up. Patients were categorized according to quartiles of TyG. After adjusting for confounders, the risk of sICAS was greater (OR 1.59, 95% CI 1.04–2.43, p = 0.033) and the risk of stroke recurrence was significantly higher (HR 2.02, 95% CI 1.07–3.84, p = 0.025) in the fourth TyG quartile than in the first quartile. The restricted cubic spline (RCS) plot revealed a linear relationship between TyG and sICAS, and the threshold value for TyG was 8.4. Patients were then dichotomized into low and high TyG groups by the threshold. Patients with high TyG combined with sICAS had a higher risk of recurrence (HR 2.54, 95% CI 1.39–4.65) than patients with low TyG without sICAS. An interaction effect on stroke recurrence between TyG and sICAS was found (p = 0.043). Conclusion TyG is a significant risk factor for sICAS in hypertensive patients, and there is a synergistic effect of sICAS and higher TyG on ischemic stroke recurrence. Trial registration number: The study was registered on 16 August 2019 at https://www.chictr.org.cn/showprojen.aspx?proj=41160 (No. ChiCTR1900025214).
    Type of Medium: Online Resource
    ISSN: 1475-2840
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2093769-6
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  • 3
    In: Cardiovascular Drugs and Therapy, Springer Science and Business Media LLC
    Type of Medium: Online Resource
    ISSN: 0920-3206 , 1573-7241
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2003553-6
    SSG: 15,3
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  • 4
    In: Advanced Optical Materials, Wiley, Vol. 10, No. 22 ( 2022-11)
    Abstract: The luminescence thermal quenching (LTQ) behavior is one of the detrimental effects which result in poor stability and hinder the practical applications of luminescent nanocrystals (NCs) severely. Suppressing the LTQ effect is fundamentally important, especially for the recent rising star lead halide perovskite NCs while related investigations are rare. Herein, taking CsPbBr 3 NCs with high photoluminescence quantum yield (PLQY) as examples, a surface anchoring mechanism is proposed and the LTQ effect is successfully overcome. By introducing hybrid ligand system with large binding effect and steric hindrance, ligand desorption induces irreversible LTQ effect and the formation of surface atom vibration related transient traps is suppressed. As a result, 96.3% and 75.6% of the initial PL intensity are maintained up to 378 and 423 K, respectively, which are even superior to conventional core–shell NCs. Notably, after being treated under 333 K for 15 days, a PL intensity remnant of 〉 88.4% is achieved. Such anti‐LTQ mechanism is also extended to blue perovskite NCs. Temperature‐tolerant stimulated emission and high temperature lasing phenomenon are fulfilled with considerable thermal stability. This work provides a new mechanism which can possibly help to solve the bottleneck toward practical luminescence applications for perovskite nanostructures.
    Type of Medium: Online Resource
    ISSN: 2195-1071 , 2195-1071
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2708158-8
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  • 5
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2020
    In:  Fish Physiology and Biochemistry Vol. 46, No. 2 ( 2020-04), p. 759-770
    In: Fish Physiology and Biochemistry, Springer Science and Business Media LLC, Vol. 46, No. 2 ( 2020-04), p. 759-770
    Type of Medium: Online Resource
    ISSN: 0920-1742 , 1573-5168
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2015453-7
    SSG: 21,3
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2022
    In:  Nature Communications Vol. 13, No. 1 ( 2022-04-29)
    In: Nature Communications, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2022-04-29)
    Abstract: Organic semiconductors offer a tunable platform for photocatalysis, yet the more difficult exciton dissociation, compared to that in inorganic semiconductors, lowers their photocatalytic activities. In this work, we report that the charge carrier lifetime is dramatically prolonged by incorporating a suitable donor-acceptor (β-ketene-cyano) pair into a covalent organic framework nanosheet. These nanosheets show an apparent quantum efficiency up to 82.6% at 450 nm using platinum as co-catalyst for photocatalytic H 2 evolution. Charge carrier kinetic analysis and femtosecond transient absorption spectroscopy characterizations verify that these modified covalent organic framework nanosheets have intrinsically lower exciton binding energies and longer-lived charge carriers than the corresponding nanosheets without the donor-acceptor unit. This work provides a model for gaining insight into the nature of short-lived active species in polymeric organic photocatalysts.
    Type of Medium: Online Resource
    ISSN: 2041-1723
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2553671-0
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  • 7
    Online Resource
    Online Resource
    Frontiers Media SA ; 2022
    In:  Frontiers in Plant Science Vol. 13 ( 2022-9-29)
    In: Frontiers in Plant Science, Frontiers Media SA, Vol. 13 ( 2022-9-29)
    Abstract: Despite the importance of non-structural carbohydrates (NSC) for growth and survival in woody plants, we know little about whole-tree NSC storage. Here, Catalpa bungei trees fertilized using different schedules, including water and fertilizer integration, hole application, and no fertilization, were used to measure the spatial variations of sugar, starch, and NSC concentrations in the leaf, branch, stem, bark, and root. By calculating the volume of whole-tree NSC pools and the contribution of distinct organs, we were also able to compare the storage under various fertilization regimes. We found that the spatial distribution patterns of each organ undergoing different fertilization regimes were remarkably similar. Height-related increases in the sugar and NSC concentrations of the leaf and bark were observed. The concentrations of sugar and NSC in the branch did not appear to vary longitudinally or horizontally. The sugar and NSC concentrations in the stem fluctuated with height, first falling and then rising. The coarse root contained larger amounts of NSC components in comparison to fine root. Contrary to no fertilization, fertilization enhanced the distribution ratio of the leaf, branch, and stem NSC pools while decreasing the distribution ratio of the root NSC pool. Particularly, the addition of fertilizer and water significantly increased the biomass of the organs, enhancing the carbon sink of each organ and whole-tree in comparison to other fertilization regimes. Our main goal was to strengthen the empirical groundwork for comprehending the functional significance of NSC allocation and stock variations at the organ-level of C. bungei trees.
    Type of Medium: Online Resource
    ISSN: 1664-462X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2687947-5
    detail.hit.zdb_id: 2613694-6
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  • 8
    Online Resource
    Online Resource
    Frontiers Media SA ; 2023
    In:  Frontiers in Endocrinology Vol. 14 ( 2023-2-27)
    In: Frontiers in Endocrinology, Frontiers Media SA, Vol. 14 ( 2023-2-27)
    Abstract: The relationship between thyroid autoimmunity (TAI) and adverse pregnancy outcomes is disputable, and their dose-dependent association have not been fully clarified. Objective To investigate the association and dose-dependent effect of TAI with multiple maternal and fetal-neonatal complications. Methods This study is a multi-center retrospective cohort study based on singleton pregnancies of three medical college hospitals from July 2013 to October 2021. The evolution of thyroid function parameters in TAI and not TAI women were described, throughout pregnancy. The prevalences of maternal and fetal-neonatal complications were compared between the TAI and control group. Logistic regression was performed to study the risk effects and dose-dependent effects of thyroid autoantibodies on pregnancy complications, with adjustment of maternal age, BMI, gravidity, TSH concentrations, FT4 concentrations and history of infertility. Results A total of 27408 participants were included in final analysis, with 5342 (19.49%) in the TAI group and 22066 (80.51%) in control group. TSH concentrations was higher in TAI women in baseline and remain higher before the third trimester. Positive thyroid autoantibodies were independently associated with higher risk of pregnancy-induced hypertension (OR: 1.215, 95%CI: 1.026-1.439), gestational diabetes mellitus (OR: 1.088, 95%CI: 1.001-1.183), and neonatal admission to NICU (OR: 1.084, 95%CI: 1.004-1.171). Quantitative analysis showed that increasing TPOAb concentration was correlated with higher probability of pregnancy-induced hypertension, and increasing TGAb concentration was positively correlated with pregnancy-induced hypertension, small for gestational age and NICU admission. Both TPOAb and TGAb concentration were negatively associated with neonatal birthweight. Conclusion Thyroid autoimmunity is independently associated with pregnancy-induced hypertension, gestational diabetes mellitus, neonatal lower birthweight and admission to NICU. Dose-dependent association were found between TPOAb and pregnancy-induced hypertension, and between TGAb and pregnancy-induced hypertension, small for gestational age and NICU admission.
    Type of Medium: Online Resource
    ISSN: 1664-2392
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2592084-4
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  • 9
    Online Resource
    Online Resource
    Elsevier BV ; 2024
    In:  International Journal of Biological Macromolecules Vol. 261 ( 2024-03), p. 129672-
    In: International Journal of Biological Macromolecules, Elsevier BV, Vol. 261 ( 2024-03), p. 129672-
    Type of Medium: Online Resource
    ISSN: 0141-8130
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2024
    detail.hit.zdb_id: 1483284-7
    SSG: 12
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  • 10
    Online Resource
    Online Resource
    Frontiers Media SA ; 2024
    In:  Frontiers in Forests and Global Change Vol. 7 ( 2024-4-24)
    In: Frontiers in Forests and Global Change, Frontiers Media SA, Vol. 7 ( 2024-4-24)
    Abstract: The development and morphology of branches, a crucial step in producing high-quality large-diameter lumber, may be influenced by fertilization. The response of branch attributes to different fertilization regimes, however, is still poorly understood. The Catalpa bungei plantations, which had been growing for 6 years in northern China, were chosen to study how various fertilization measures affected branch attributes. The two fertilization techniques used were hole fertilization (HF) and water and fertilizer integration (WF), with no fertilization (CK) as a control. The quantity, density, morphology (e.g., diameter, length, and angle), and position (e.g., height and orientation) of branches, and organ biomass of 18 standard trees (total of 516 branches) were investigated. The results demonstrated a considerable increase in tree height, diameter at breast height (DBH), canopy ratio, branch quantity, and organ biomass following the addition of fertilizer. Both the maximum branch diameter and the number of branches rose with fertilization. Following fertilization, the number of branches rose by 16% (HF) and 28% (WF) compared to non-fertilized trees, while the maximum branch diameter increased by 3.5% (HF) and 17.3% (WF), respectively. WF led to an increase in the number of branches and largest branch diameter in comparison to CK and HF. The length, angle, and diameter of branches, however, were not affected significantly by different fertilization treatments. There were roughly equal amounts of branches in four orientations. The mixed-model analysis revealed that the number of branches was positively correlated with branch density and tree height. The branch diameter increased with the increase of branch length and angle. The branch length was negatively correlated with branch height and angle. The branch angle showed a larger angle at the bottom of the canopy. Tree height plus diameter at breast height combined, or just the diameter at breast height indicator alone, can both reliably predict the total biomass of trees. The branch models created in this research may offer some theoretical backing for understanding the crown dynamics of valuable tree species in northern China.
    Type of Medium: Online Resource
    ISSN: 2624-893X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2024
    detail.hit.zdb_id: 2968523-0
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