In:
Cardiovascular Innovations and Applications, Compuscript, Ltd., Vol. 7, No. 1 ( 2023)
Abstract:
Objective: This study evaluated the optimal systolic blood pressure (SBP) target for older patients with hypertension. Method: A Bayesian network meta-analysis was conducted. The risk of bias of the included studies was assessed by using a modified version of the Cochrane risk of bias. The trial outcomes comprised the following clinical events: major adverse cardiovascular events (MACE), cardiovascular mortality, all-cause mortality, myocardial infarction, heart failure and stroke. Results: A total of six trials were included. We reclassified all treatment therapies into three conditions according to the final achieved SBP after intervention ( 〈 130 mmHg, 130–139 mmHg and ≥140 mmHg). Our results demonstrated that anti-hypertensive treatment with an SBP target 〈 130 mmHg, compared with treatment with an SBP target ≥140 mmHg, significantly decreased the incidence of MACE (OR 0.43, 95%CI 0.19–0.76), but no statistical difference was found in other comparisons. Although the results showed a trend toward more intensive anti-hypertension therapy having better effects on preventing cardiovascular mortality, all-cause mortality, myocardial infarction, heart failure, and stroke, no significant differences were found among groups. Conclusions: Our meta-analysis suggested that SBP 〈 130 mmHg might be the optimal BP control target for patients ≥60 years of age; however, further evidence is required to support our findings.
Type of Medium:
Online Resource
ISSN:
2009-8618
,
2009-8782
DOI:
10.15212/CVIA.2023.0008
Language:
English
Publisher:
Compuscript, Ltd.
Publication Date:
2023
detail.hit.zdb_id:
3018803-9
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