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  • Hindawi Limited  (21)
  • Wang, Jie  (21)
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  • Hindawi Limited  (21)
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  • 1
    Online Resource
    Online Resource
    Clinical Effect of Nursing Based on the Kano Model in Emergency Multiple Injuries
    Hindawi Limited ; 2022
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2022 ( 2022-7-14), p. 1-7
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2022 ( 2022-7-14), p. 1-7
    Abstract: Multiple injury refers to the injury of two or more anatomical parts of the body caused by mechanical injury factors. Even if only one injury exists alone, it can endanger limbs or lives. Therefore, nursing plays an important role in its treatment. Here, we investigated the application and clinical effect of nursing based on the Kano model in emergency multiple injuries. A case-control study was designed, where 48 patients with multiple injuries in the emergency department were divided into the control group to perform routine care and 48 patients were divided into the study group to carry on nursing based on the Kano model. The first-aid indexes, success rate of rescue, inflammatory response indicators, satisfaction rate of nursing, incidence of adverse events, and prognosis were compared between the two groups. A monofactor analysis showed that the emergency response time, admission time, and emergency department rescue time were shorter in the study group than those in the control group, indicating a higher success rate of rescue with nursing based on the Kano model. For the immunity of patients, the scores of mental states and the serum levels of inflammatory factors were lower in the study group than those in the control group. In addition, the rate of nursing satisfaction and good prognosis in the study group was significantly higher than those in the control group, and the incidence of adverse events was significantly lower than that in the control group. These results indicated that nursing based on the Kano model in patients with emergency multiple injuries can reduce the body inflammatory reaction, reduce the risk of adverse events, improve the prognosis of patients, and obtain high patient satisfaction.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2022/3586290
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2148302-4
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  • 2
    Online Resource
    Online Resource
    Simultaneous Determination of 8 Small Antihypertensive Peptides with Tyrosine at the C-Terminal in L aminaria japonica Hydrolysates by RP-HPLC Method : Small Peptides in Laminaria japonica Hydrolysates
    Hindawi Limited ; 2016
    In:  Journal of Food Processing and Preservation Vol. 40, No. 3 ( 2016-06), p. 492-501
    Details
    In: Journal of Food Processing and Preservation, Hindawi Limited, Vol. 40, No. 3 ( 2016-06), p. 492-501
    Type of Medium: Online Resource
    ISSN: 0145-8892
    URL: Article
    DOI: 10.1111/jfpp.12628
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2175273-4
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  • 3
    Online Resource
    Online Resource
    Analysis of Anesthesia Methods in Percutaneous Kyphoplasty for Treatment of Vertebral Compression Fractures
    Hindawi Limited ; 2020
    In:  Journal of Healthcare Engineering Vol. 2020 ( 2020-01-09), p. 1-6
    Details
    In: Journal of Healthcare Engineering, Hindawi Limited, Vol. 2020 ( 2020-01-09), p. 1-6
    Abstract: Aim . Percutaneous kyphoplasty (PKP) is a routine operation for the treatment of vertebral compression fracture (VCF). Both local anesthesia and general anesthesia are widely used for PKP. However, which type of anesthesia is better for PKP still remains uncertain. This study aimed to find out whether local anesthesia or general anesthesia is more suitable for PKP. Methods . This is a retrospective clinical trial. A total of 85 single-level VCF patients who received PKP 12 months ago were recruited in this study. 45 patients who received local anesthesia were in group L, and 40 patients with general anesthesia were in group G. Clinical, radiological, and economic data between the two groups were collected. Results . No difference was found on preoperative data between the two groups. The duration of operation time in group L was longer than that in group G. Within 12 months after PKP, more complications happened in group G than those in group L. Results . This study found that there was no difference between group L and group G before the operation in terms of baseline. The operation time in group L was shorter than that in group G and the difference was significant. The VAS pain score in group L was significantly higher than that in group G. Clinical and radiological indicators were all improved after surgery, while no other difference was detected between the two groups. More severe complications happened in group G within 12 months after PKP, and the cost in group L was significantly less than that in group G. Conclusion . Both local anesthesia and general anesthesia were reliable for PKP. However, local anesthesia was more efficient and safer with less expense and more bearable pain when compared with general anesthesia.
    Type of Medium: Online Resource
    ISSN: 2040-2295 , 2040-2309
    URL: Article
    DOI: 10.1155/2020/3965961
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2545054-2
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  • 4
    Online Resource
    Online Resource
    Identification of a Novel ACTN4 Gene Mutation Which Is Resistant to Primary Nephrotic Syndrome Therapy
    Hindawi Limited ; 2019
    In:  BioMed Research International Vol. 2019 ( 2019-12-16), p. 1-7
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2019 ( 2019-12-16), p. 1-7
    Abstract: ACTN4 , a gene which codes for the protein α -actinin-4, is critical for the maintenance of the renal filtration barrier. It is well known that ACTN4 mutations can lead to kidney dysfunction, such as familial focal segmental glomerulosclerosis (FSGS), a common cause of primary nephrotic syndrome (PNS). To elucidate whether other mutations of ACTN4 exist in PNS patients, we sequenced the ACTN4 gene in biopsies collected from 155 young PNS patients (≤16 years old). The patients were classified into five groups: FSGS, minimal change nephropathy, IgA nephropathy, membranous nephropathy, and those without renal puncture. Ninety-eight healthy people served as controls. Samples were subjected to Illumina’s next generation sequencing protocols using FastTarget target gene capture method. We identified 5 ACTN4 mutations which occurred only in PNS patients: c.1516G  〉  A (p.G506S) on exon 13 identified in two PNS patients, one with minimal change nephropathy and another without renal puncture; c.1442 + 10G  〉  A at the splice site in a minimal change nephropathy patient; c.2191-4G  〉  A at the cleavage site, identified from two FSGS patients; and c.1649A  〉  G (p.D550G) on exon 14 together with c.2191-4G  〉  A at the cleavage sites, identified from two FSGS patients. Among these, c.1649A  〉  G (p.D550G) is a novel ACTN4 mutation. Patients bearing the last two mutations exhibited resistance to clinical therapies.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2019/5949485
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2698540-8
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  • 5
    Online Resource
    Online Resource
    Wireless Sensor-Based Smart-Clothing Platform for ECG Monitoring
    Hindawi Limited ; 2015
    In:  Computational and Mathematical Methods in Medicine Vol. 2015 ( 2015), p. 1-8
    Details
    In: Computational and Mathematical Methods in Medicine, Hindawi Limited, Vol. 2015 ( 2015), p. 1-8
    Abstract: The goal of this study is to use wireless sensor technologies to develop a smart clothes service platform for health monitoring. Our platform consists of smart clothes, a sensor node, a gateway server, and a health cloud. The smart clothes have fabric electrodes to detect electrocardiography (ECG) signals. The sensor node improves the accuracy of QRS complexes detection by morphology analysis and reduces power consumption by the power-saving transmission functionality. The gateway server provides a reconfigurable finite state machine (RFSM) software architecture for abnormal ECG detection to support online updating. Most normal ECG can be filtered out, and the abnormal ECG is further analyzed in the health cloud. Three experiments are conducted to evaluate the platform’s performance. The results demonstrate that the signal-to-noise ratio (SNR) of the smart clothes exceeds 37 dB, which is within the “very good signal” interval. The average of the QRS sensitivity and positive prediction is above 99.5%. Power-saving transmission is reduced by nearly 1980 times the power consumption in the best-case analysis.
    Type of Medium: Online Resource
    ISSN: 1748-670X , 1748-6718
    URL: Article
    DOI: 10.1155/2015/295704
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2256917-0
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  • 6
    Online Resource
    Online Resource
    Defect Contour Detection of Complex Structural Chips
    Hindawi Limited ; 2021
    In:  Mathematical Problems in Engineering Vol. 2021 ( 2021-5-27), p. 1-11
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2021 ( 2021-5-27), p. 1-11
    Abstract: In the manufacture of chips, it is important to detect defects to assess whether the chip is potentially damageable that could cause unnecessary cost. Most assessment rules are set in light of characteristics determined by defect contours, such as area and range. However, conventional image process methods seldom show a satisfactory performance on chips with complex structures because they are difficult to distinguish defect contours from edges of structures. To solve this issue, this study proposes a method based on region segmentation search. The positions of structures in the image are calculated by edge matching to obtain the number of structure layers in each pixel. Regions whose pixels have the same number are divided into subregions which are coded by the two-pass algorithm. The edges in each subregion are then extracted by the Canny operator to construct edge information of the whole image. Interpolation is used to correct incomplete defect edges according to their endpoints. The remaining interference contours are eliminated on the basis of their shapes. A study of a certain kind of chips is presented. Different illumination situations were simulated to verify the robustness of the proposed method. Most bubbles in the images were detected successfully with their contours coded accurately. Because of this, more than 92% of assessment results of chips were identical to the ones in reality engineering, which proves that the method proposed by this study can efficiently detect the defect contours and improve the ability obviously relative to the current approaches.
    Type of Medium: Online Resource
    ISSN: 1563-5147 , 1024-123X
    URL: Article
    DOI: 10.1155/2021/5518675
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 7
    Online Resource
    Online Resource
    Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer
    Hindawi Limited ; 2021
    In:  Mediators of Inflammation Vol. 2021 ( 2021-4-1), p. 1-20
    Details
    In: Mediators of Inflammation, Hindawi Limited, Vol. 2021 ( 2021-4-1), p. 1-20
    Abstract: Non-small-cell lung cancer (NSCLC) remains the most common malignancy with the highest morbidity and mortality worldwide. In our previous study, we found that a classic traditional Chinese medicine (TCM) formula Ze-Qi-Tang (ZQT), which has been used in the treatment of respiratory diseases for thousands of years, could directly inhibit the growth of human NSCLC cells via the p53 signaling pathway. In this study, we explored the immunomodulatory functions of ZQT. We found that ZQT significantly prolonged the survival of orthotopic lung cancer model mice by modulating the tumor microenvironment (TME). ZQT remarkably reduced the number of MDSCs (especially G-MDSCs) and inhibited their immunosuppressive activity by inducing apoptosis in these cells via the STAT3/S100A9/Bcl-2/caspase-3 signaling pathway. When G-MDSCs were depleted, the survival promotion effect of ZQT and its inhibitory effect on lung luminescence signal disappeared in tumor-bearing mice. This is the first study to illustrate the immunomodulatory effect of ZQT in NSCLC and the underlying molecular mechanism.
    Type of Medium: Online Resource
    ISSN: 1466-1861 , 0962-9351
    URL: Article
    DOI: 10.1155/2021/8856326
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2008065-7
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  • 8
    Online Resource
    Online Resource
    A Novel Necroptosis-Related miRNA Signature for Predicting the Prognosis of Breast Cancer Metastasis
    Hindawi Limited ; 2022
    In:  Disease Markers Vol. 2022 ( 2022-3-25), p. 1-9
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2022 ( 2022-3-25), p. 1-9
    Abstract: Objective. Necroptosis was recently identified as a form of programmed cell death that plays an essential role in breast cancer metastasis. MicroRNAs (miRNAs) have long been recognized to affect cell death and tumor growth. In this study, we aimed to screen for necroptosis-associated miRNAs that predict breast cancer metastasis. Method. This study used The Cancer Genome Atlas (TCGA) public database to obtain miRNA expression data and associated clinical data from breast cancer patients and then retrieved miRNA data related to necrosis and apoptosis. Next, using Cox regression model analysis (univariate or multivariate) as well as a comparison analysis (differential analysis), a prognostic multi-miRNA molecular marker was established. Finally, prognosis-related miRNAs were utilized to identify target genes, and the functions of the target genes were analyzed for enrichment to investigate the probable mechanisms of the miRNAs. Results. Ten miRNAs were screened through differential analysis to build models: hsa-miR-148a-3p, hsa-miR-223-3p, hsa-miR-331-3p, has-miR-181a-5p, hsa-miR-181b-5p, hsa-miR-181c-5p, hsa-miR-181d-5p, hsa-miR-200a-5p, hsa-miR-141-3p, and hsa-miR-425-5p. The multivariate Cox regression model was an independent prognostic factor (univariate Cox regression results: HR = 3.2642 , 95 % CI = 1.5773 − 6.7554 , P = 0.0014 ; multivariate Cox regression results: HR = 3.1578 , 95 % CI = 1.5083 − 6 , P = 0.0023 ). The survival curve of the risk score also revealed that patients with a high risk score had a poor prognosis ( P = 2 e − 04 ). The receiver operating characteristic (ROC) curve showed that the model has a certain prediction ability. Batch survival analysis of the miRNAs in the model was conducted and showed that hsa-miR-331-3p ( P = 0.0182 ) was strongly associated with prognosis. Twenty-three predicted target genes were obtained, and Gene Ontology (GO) enrichment analysis showed that these target genes were strongly enriched in transcriptional initiation and cell membrane trafficking. Conclusion. Our research identified a novel miRNA marker for predicting breast cancer patient prognosis and lays the groundwork for future research on necroptosis-related genes.
    Type of Medium: Online Resource
    ISSN: 1875-8630 , 0278-0240
    URL: Article
    DOI: 10.1155/2022/3391878
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2033253-1
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  • 9
    Online Resource
    Online Resource
    New Choke Ring Design for Eliminating Multipath Effects in the GNSS System
    Hindawi Limited ; 2022
    In:  International Journal of Antennas and Propagation Vol. 2022 ( 2022-10-11), p. 1-6
    Details
    In: International Journal of Antennas and Propagation, Hindawi Limited, Vol. 2022 ( 2022-10-11), p. 1-6
    Abstract: An anti-multipath antenna is an antenna that can effectively suppress multipath signals from the source of signal reception. There are many problems in the traditional choke design, such as excessive volume and low elevation gain damage. In this paper, the conventional choke ring is improved by using the complementary trapezoidal structure, and the detailed design process is given. The measured results show that the choke has good resistance to a multipath effect in the navigation frequency band (1.1–1.7 GHz) and can significantly improve the front-to-back ratio of the antenna.
    Type of Medium: Online Resource
    ISSN: 1687-5877 , 1687-5869
    URL: Article
    DOI: 10.1155/2022/1527674
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2397585-4
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  • 10
    Online Resource
    Online Resource
    Analysis of the Molecular Mechanism of Acute Coronary Syndrome Based on circRNA-miRNA Network Regulation
    Hindawi Limited ; 2020
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2020 ( 2020-04-29), p. 1-17
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2020 ( 2020-04-29), p. 1-17
    Abstract: Background . With the development of biological technology, biomarkers for the prevention and diagnosis of acute coronary syndrome (ACS) have become increasingly evident. However, the study of novel circular RNAs (circRNAs) in ACS is still in progress. This study aimed to investigate whether the regulation of circRNA-miRNA networks is involved in ACS pathogenesis. Methods . We used microarray analysis to detect significantly expressed circRNAs and miRNAs in the peripheral blood of patients in the control group (CG) and ACS groups, including an unstable angina pectoris (UAP) group and an acute myocardial infarction (AMI) group. A circRNA-miRNA interaction network analysis was carried out with open-source bioinformatics. The gene ontology (GO), pathway, and disease enrichment analyses for differentially expressed circRNAs were further analysed with hierarchical clustering. Results . A total of 266 circRNAs (121 upregulated and 145 downregulated, P 〈 0.05 , fold change FC ≥2) and 3 miRNAs (1 upregulated and 2 downregulated, P 〈 0.05 , FC ≥ 1.2) were differentially expressed in the ACS groups compared with those in the CG. In addition, among these expressed circRNAs and miRNAs, a single circRNA could bind to more than 1–100 miRNAs, and vice versa. Next, an AMI-UAP network, an AMI-CG network, a UAP-CG network, and an AMI-CG-UAP network were constructed. The top 30 enriched GO terms among the three groups were emphasized as differentially expressed. Disease enrichment analysis showed that these differentially expressed circRNAs are involved in the pathogenesis of cardiovascular diseases. KEGG pathway analysis was performed to identify pathways associated with circRNAs targeting mRNAs. Conclusion . CircRNAs are closely related to the pathological process of ACS via a mechanism that may be related to the up- or down-regulation of circRNAs and miRNAs and circRNA-miRNA coexpression. The metabolic pathways, signalling pathways, and diseases affected by these circRNAs can be predicted by enrichment analysis.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2020/1584052
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2148302-4
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