In:
Cancer Science, Wiley, Vol. 109, No. 2 ( 2018-02), p. 340-353
Abstract:
Long non‐coding RNA s (lnc RNA s) are transcripts longer than 200 nt that are involved in tumorigenesis and play a key role in cancer progression. To determine whether lnc RNA s are involved in acute myeloid leukemia ( AML ), we analyzed the expression profile of lnc RNA s and mRNA s in AML . Five pairs of AML patients and iron deficiency anemia ( IDA ) controls were screened by microarray. Through coexpression analysis, differently expressed transcripts were divided into modules, and lnc RNA s were functionally annotated. We further analyzed the clinical significance of crucial lnc RNA s from modules in public data. Finally, the expression of three lnc RNA s, RP 11‐222K16.2, AC 092580.4, and RP 11‐305O.6, were validated in newly diagnosed AML , AML relapse, and IDA patient groups by quantitative RT ‐ PCR , which may be associated with AML patients’ overall survival. Further analysis showed that RP 11‐222K16.2 might affect the differentiation of natural killer cells, and promote the immunized evasion of AML by regulating Eomesodermin expression. Analysis of this study revealed that dysregulated lnc RNA s and mRNA s in AML vs IDA controls could affect the immune system and hematopoietic cell differentiation. The biological functions of those lnc RNA s need to be further validated.
Type of Medium:
Online Resource
ISSN:
1347-9032
,
1349-7006
DOI:
10.1111/cas.2018.109.issue-2
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2115647-5
detail.hit.zdb_id:
2111204-6
Permalink