GLORIA

GEOMAR Library Ocean Research Information Access

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • MDPI AG  (4)
  • Wang, Jianhai  (4)
Material
Publisher
  • MDPI AG  (4)
Language
Years
  • 1
    Online Resource
    Online Resource
    MDPI AG ; 2024
    In:  Processes Vol. 12, No. 3 ( 2024-02-22), p. 447-
    In: Processes, MDPI AG, Vol. 12, No. 3 ( 2024-02-22), p. 447-
    Abstract: Fractured-vuggy carbonate reservoirs are tectonically complex; their reservoirs are dominated by holes and fractures, which are extremely nonhomogeneous and are difficultly exploited. Conventional water injection can lead to water flooding, and the recovery effect is poor. This paper takes the injection of foam and solid particles to control bottom water as the research direction. Firstly, the rheological properties of foam were studied under different foam qualities and the presence of particles. The ability of foam to carry particles was tested. By designing a microcosmic model of a fractured-vuggy reservoir, we investigated the remaining oil types and the distribution caused by bottom water. Additionally, we analyzed the mechanisms of remaining oil mobilization and bottom water plugging during foam flooding and foam–particle co-injection. The experimental results showed that foam was a typical power-law fluid. Foam with a quality of 80% had good stability and apparent viscosity. During foam flooding, foam floated at the top of the dissolution cavities, effectively driving attic oil. Additionally, the gas cap is released when the foam collapses, which can provide pressure energy to supplement the energy of the reservoir. Collaborative injection of foam and solid particles into the reservoir possessed several advantages. On one hand, it inherited the benefits of foam flooding. On the other hand, the foam transported particles deep into the reservoir. Under the influence of gravity, particles settled and accumulated in the fractures or cavities, forming bridge plugs at the connection points, effectively controlling bottom water channeling. The co-injection of foam and solid particles holds significant potential for applications.
    Type of Medium: Online Resource
    ISSN: 2227-9717
    Language: English
    Publisher: MDPI AG
    Publication Date: 2024
    detail.hit.zdb_id: 2720994-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    Online Resource
    Online Resource
    MDPI AG ; 2022
    In:  International Journal of Molecular Sciences Vol. 23, No. 23 ( 2022-12-01), p. 15065-
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 23, No. 23 ( 2022-12-01), p. 15065-
    Abstract: Lung homeostasis and regeneration depend on lung epithelial progenitor cells. Lkb1 (Liver Kinase B1) has known roles in the differentiation of airway epithelial cells during embryonic development. However, the effects of Lkb1 in adult lung epithelial progenitor cell regeneration and its mechanisms of action have not been determined. In this study, we investigated the mechanism by which Lkb1 regulates lung epithelial progenitor cell regeneration. Organoid culture showed that loss of Lkb1 significantly reduced the proliferation of club cells and alveolar type 2 (AT2) cells in vitro. In the absence of Lkb1, there is a slower recovery rate of the damaged airway epithelium in naphthalene-induced airway epithelial injury and impaired expression of surfactant protein C during bleomycin-induced alveolar epithelial damage. Moreover, the expression of autophagy-related genes was reduced in club cells and increased in AT2 cells, but the expression of Claudin-18 was obviously reduced in AT2 cells after Lkb1 knockdown. On the whole, our findings indicated that Lkb1 may promote the proliferation of lung epithelial progenitor cells via a niche-dependent pathway and is required for the repair of the damaged lung epithelium.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2019364-6
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    In: Energies, MDPI AG, Vol. 14, No. 22 ( 2021-11-12), p. 7554-
    Abstract: A reservoir-scale numerical conceptual model was established according to the actual geological characteristics of a carbonate fractured-vuggy reservoir. Considering the difference in density and viscosity of fluids under reservoir conditions, CFD (computational fluid dynamic) porous medium model was applied to simulate the process of nitrogen displacement in a fractured-vuggy reservoir after water flooding. The effects of gas injection rate, injection mode, and injector–producer location relation were studied. The results show that nitrogen flooding can yield additional oil recovery of 7–15% after water flooding. Low-speed nitrogen injection is beneficial in obtaining higher oil recovery. High speed injection can expand the sweep area, but gas channeling occurs more easily. In gas–water mixed injection mode, there is fluid disturbance in the reservoir. The gas channeling is faster in low injector–high producer mode, while the high injector–low producer mode is beneficial for increasing the gas sweep range. Nevertheless, the increment of recovery is closely related to well pattern. After nitrogen flooding, there are still a lot of remaining oil distributed in the trap area of gas cap and bottom water in the reservoir that water and gas injection can’t sweep. The establishment of the numerical conceptual model compensates for the deficiency of physical simulation research, stating that only limited parameters can be simulated during experiments, and provides theoretical bases for nitrogen flooding in fractured-vuggy reservoir.
    Type of Medium: Online Resource
    ISSN: 1996-1073
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2437446-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 4
    In: Biomolecules, MDPI AG, Vol. 12, No. 5 ( 2022-05-22), p. 728-
    Abstract: (1) Background: Abnormal repair after alveolar epithelial injury drives the progression of idiopathic pulmonary fibrosis (IPF). The maintenance of epithelial integrity is based on the self-renewal and differentiation of alveolar type 2 (AT2) cells, which require sufficient energy. However, the role of glutamine metabolism in the maintenance of the alveolar epithelium remains unclear. In this study, we investigated the role of glutamine metabolism in AT2 cells of patients with IPF and in mice with bleomycin-induced fibrosis. (2) Methods: Single-cell RNA sequencing (scRNA-seq), transcriptome, and metabolomics analyses were conducted to investigate the changes in the glutamine metabolic pathway during pulmonary fibrosis. Metabolic inhibitors were used to stimulate AT2 cells to block glutamine metabolism. Regeneration of AT2 cells was detected using bleomycin-induced mouse lung fibrosis and organoid models. (3) Results: Single-cell analysis showed that the expression levels of catalytic enzymes responsible for glutamine catabolism were downregulated (p 〈 0.001) in AT2 cells of patients with IPF, suggesting the accumulation of unusable glutamine. Combined analysis of the transcriptome (p 〈 0.05) and metabolome (p 〈 0.001) revealed similar changes in glutamine metabolism in bleomycin-induced pulmonary fibrosis in mice. Mechanistically, inhibition of the key enzymes involved in glucose metabolism, glutaminase-1 (GLS1) and glutamic-pyruvate transaminase-2 (GPT2) leads to reduced proliferation (p 〈 0.01) and differentiation (p 〈 0.01) of AT2 cells. (4) Conclusions: Glutamine metabolism is required for alveolar epithelial regeneration during lung injury.
    Type of Medium: Online Resource
    ISSN: 2218-273X
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2701262-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...