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  • Oxford University Press (OUP)  (193)
Materialart
Verlag/Herausgeber
  • Oxford University Press (OUP)  (193)
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  • 1
    In: Horticulture Research, Oxford University Press (OUP), Vol. 8, No. 1 ( 2021-12)
    Kurzfassung: The marvelously diverse Orchidaceae constitutes the largest family of angiosperms. The genus Cymbidium in Orchidaceae is well known for its unique vegetation, floral morphology, and flower scent traits. Here, a chromosome-scale assembly of the genome of Cymbidium ensifolium (Jianlan) is presented. Comparative genomic analysis showed that C. ensifolium has experienced two whole-genome duplication (WGD) events, the most recent of which was shared by all orchids, while the older event was the τ event shared by most monocots. The results of MADS-box genes analysis provided support for establishing a unique gene model of orchid flower development regulation, and flower shape mutations in C. ensifolium were shown to be associated with the abnormal expression of MADS-box genes. The most abundant floral scent components identified included methyl jasmonate, acacia alcohol and linalool, and the genes involved in the floral scent component network of C. ensifolium were determined. Furthermore, the decreased expression of photosynthesis-antennae and photosynthesis metabolic pathway genes in leaves was shown to result in colorful striped leaves, while the increased expression of MADS-box genes in leaves led to perianth-like leaves. Our results provide fundamental insights into orchid evolution and diversification.
    Materialart: Online-Ressource
    ISSN: 2662-6810 , 2052-7276
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 2021
    ZDB Id: 2781828-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    In: Horticulture Research, Oxford University Press (OUP), Vol. 8 ( 2021-12-01)
    Materialart: Online-Ressource
    ISSN: 2052-7276
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 2021
    ZDB Id: 2781828-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    In: Monthly Notices of the Royal Astronomical Society, Oxford University Press (OUP), Vol. 508, No. 1 ( 2021-10-04), p. 279-286
    Kurzfassung: The properties of the young pulsars and their relations to the supernova remnants (SNRs) have been the interesting topics. At present, 383 SNRs in the Milky Way Galaxy have been published, which are associated with 64 radio pulsars and 46 pulsars with high-energy emissions. However, we noticed that 630 young radio pulsars with the spin periods of less than half a second have been not yet observed the SNRs surrounding or nearby them, which arises a question of that could the two types of young radio pulsars with/without SNRs hold the distinctive characteristics? Here, we employ the statistical tests on the two groups of young radio pulsars with (52) and without (630) SNRs to reveal if they share the different origins. Kolmogorov–Smirnov (K–S) and Mann–Whitney–Wilcoxon (M–W–W) tests indicate that the two samples have the different distributions with parameters of spin period (P), derivative of spin period ($\dot{P}$), surface magnetic field strength (B), and energy loss rate ($\dot{E}$). Meanwhile, the cumulative number ratio between the pulsars with and without SNRs at the different spin-down ages decreases significantly after $\rm 10\!-\!20\, kyr$. So we propose that the existence of the two types of supernovae (SNe), corresponding to their SNR lifetimes, which can be roughly ascribed to the low- and high-energy SNe. Furthermore, the low-energy SNe may be formed from the $\rm 8\!-\!12\, M_{\odot }$ progenitor, e.g. possibly experiencing the electron capture, while the main-sequence stars of $\rm 12\!-\!25\, M_{\odot }$ may produce the high-energy SNe probably by the iron core collapse.
    Materialart: Online-Ressource
    ISSN: 0035-8711 , 1365-2966
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 2021
    ZDB Id: 2016084-7
    SSG: 16,12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    In: Stem Cells, Oxford University Press (OUP), Vol. 37, No. 7 ( 2019-07-01), p. 958-972
    Kurzfassung: Direct in vivo reprogramming of cardiac fibroblasts into myocytes is an attractive therapeutic intervention in resolving myogenic deterioration. Current transgene-dependent approaches can restore cardiac function, but dependence on retroviral delivery and persistent retention of transgenic sequences are significant therapeutic hurdles. Chemical reprogramming has been established as a legitimate method to generate functional cell types, including those of the cardiac lineage. Here, we have extended this approach to generate progenitor cells that can differentiate into endothelial cells and cardiomyocytes using a single inhibitor protocol. Depletion of terminally differentiated cells and enrichment for proliferative cells result in a second expandable progenitor population that can robustly give rise to myofibroblasts and smooth muscle. Deployment of a genome-wide knockout screen with clustered regularly interspaced short palindromic repeats-guide RNA library to identify novel mediators that regulate the reprogramming revealed the involvement of DNA methyltransferase 1-associated protein 1 (Dmap1). Loss of Dmap1 reduced promoter methylation, increased the expression of Nkx2-5, and enhanced the retention of self-renewal, although further differentiation is inhibited because of the sustained expression of Cdh1. Our results hence establish Dmap1 as a modulator of cardiac reprogramming and myocytic induction. Stem Cells  2019;37:958–972
    Materialart: Online-Ressource
    ISSN: 1066-5099 , 1549-4918
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 2019
    ZDB Id: 2030643-X
    ZDB Id: 1143556-2
    ZDB Id: 605570-9
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    In: Stem Cells Translational Medicine, Oxford University Press (OUP), Vol. 5, No. 2 ( 2016-02-01), p. 164-174
    Kurzfassung: Several progenitor cell populations have been reported to exist in hearts that play a role in cardiac turnover and/or repair. Despite the presence of cardiac stem and progenitor cells within the myocardium, functional repair of the heart after injury is inadequate. Identification of the signaling pathways involved in the expansion and differentiation of cardiac progenitor cells (CPCs) will broaden insight into the fundamental mechanisms playing a role in cardiac homeostasis and disease and might provide strategies for in vivo regenerative therapies. To understand and exploit cardiac ontogeny for drug discovery efforts, we developed an in vitro human induced pluripotent stem cell-derived CPC model system using a highly enriched population of KDRpos/CKITneg/NKX2.5pos CPCs. Using this model system, these CPCs were capable of generating highly enriched cultures of cardiomyocytes under directed differentiation conditions. In order to facilitate the identification of pathways and targets involved in proliferation and differentiation of resident CPCs, we developed phenotypic screening assays. Screening paradigms for therapeutic applications require a robust, scalable, and consistent methodology. In the present study, we have demonstrated the suitability of these cells for medium to high-throughput screens to assess both proliferation and multilineage differentiation. Using this CPC model system and a small directed compound set, we identified activin-like kinase 5 (transforming growth factor-β type 1 receptor kinase) inhibitors as novel and potent inducers of human CPC differentiation to cardiomyocytes. Significance Cardiac disease is a leading cause of morbidity and mortality, with no treatment available that can result in functional repair. This study demonstrates how differentiation of induced pluripotent stem cells can be used to identify and isolate cell populations of interest that can translate to the adult human heart. Two separate examples of phenotypic screens are discussed, demonstrating the value of this biologically relevant and reproducible technology. In addition, this assay system was able to identify novel and potent inducers of differentiation and proliferation of induced pluripotent stem cell-derived cardiac progenitor cells.
    Materialart: Online-Ressource
    ISSN: 2157-6564 , 2157-6580
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 2016
    ZDB Id: 2642270-0
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    In: Interactive CardioVascular and Thoracic Surgery, Oxford University Press (OUP), Vol. 34, No. 5 ( 2022-05-02), p. 799-807
    Kurzfassung: OBJECTIVES Uniportal video-assisted thoracoscopic surgery (UniVATS) is widely used as a minimally invasive thoracic operation. The goal of our study was to analyse the effect of long-term experience with the UniVATS lobectomy on the learning curve. METHODS The learning curves were quantitatively evaluated by the unadjusted cumulative sum, and they were segmented using joinpoint linear regression analysis. The variables were compared between subgroups using trend analysis, and linear regression analysis was applied to correlate clinical characteristics at different stages of the learning curve with the duration of the operation. RESULTS The learning curve for the UniVATS lobectomy can be divided into 3 phases of proficiency at ∼200–300 procedures, with a fourth phase as the number of procedures increases. The 1st–52nd, 52nd–156th, 156th–244th and 244th–538th procedures comprised the preliminary learning stage, preliminary proficiency stage, proficiency stage and advanced proficiency stage, respectively. Surgical outcomes and their variability between stages improved with increasing case numbers, with the most significant addition of an auxiliary operating port and conversions. In multivariable analysis, as stages progressed, influences other than surgical experience increased the operative time, with male and extensive pleural adhesions in the preliminary proficiency stage; male and incomplete pulmonary fissures in the proficiency stage; and male, extensive pleural adhesions and incomplete pulmonary fissures in the advanced proficiency stage. CONCLUSIONS As the number of procedures increases, there may be 4 different proficiency stages in the UniVATS lobectomy learning curve. The surgeon enters the fourth stage at approximately the 244th procedure. Moreover, at stage 4, the perioperative indicators tend to stabilize, and influences other than surgical experience become more significant.
    Materialart: Online-Ressource
    ISSN: 1569-9285
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 2022
    ZDB Id: 2096257-5
    ZDB Id: 3167862-2
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Online-Ressource
    Online-Ressource
    Oxford University Press (OUP) ; 1995
    In:  Cardiovascular Research Vol. 29, No. 1 ( 1995-1), p. 44-49
    In: Cardiovascular Research, Oxford University Press (OUP), Vol. 29, No. 1 ( 1995-1), p. 44-49
    Materialart: Online-Ressource
    ISSN: 1755-3245 , 0008-6363
    RVK:
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 1995
    ZDB Id: 1499917-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    In: Stem Cells Translational Medicine, Oxford University Press (OUP), Vol. 9, No. 1 ( 2020-01-01), p. 47-60
    Kurzfassung: Identification of small molecules with the potential to selectively proliferate cardiac progenitor cells (CPCs) will aid our understanding of the signaling pathways and mechanisms involved and could ultimately provide tools for regenerative therapies for the treatment of post-MI cardiac dysfunction. We have used an in vitro human induced pluripotent stem cell-derived CPC model to screen a 10,000-compound library containing molecules representing different target classes and compounds reported to modulate the phenotype of stem or primary cells. The primary readout of this phenotypic screen was proliferation as measured by nuclear count. We identified retinoic acid receptor (RAR) agonists as potent proliferators of CPCs. The CPCs retained their progenitor phenotype following proliferation and the identified RAR agonists did not proliferate human cardiac fibroblasts, the major cell type in the heart. In addition, the RAR agonists were able to proliferate an independent source of CPCs, HuES6. The RAR agonists had a time-of-differentiation-dependent effect on the HuES6-derived CPCs. At 4 days of differentiation, treatment with retinoic acid induced differentiation of the CPCs to atrial cells. However, after 5 days of differentiation treatment with RAR agonists led to an inhibition of terminal differentiation to cardiomyocytes and enhanced the proliferation of the cells. RAR agonists, at least transiently, enhance the proliferation of human CPCs, at the expense of terminal cardiac differentiation. How this mechanism translates in vivo to activate endogenous CPCs and whether enhancing proliferation of these rare progenitor cells is sufficient to enhance cardiac repair remains to be investigated. Significance statement Progenitor cells are rare and difficult to isolate, and little is known about the molecular mechanisms required for their proliferation and differentiation. Identification of small molecules that selectively proliferate cardiac progenitor cells will aid in the understanding of the signaling mechanisms involved and could provide tools for regenerative therapies for the treatment of cardiac dysfunction. A phenotypic screen identified retinoic acid receptor agonists as potent proliferators of induced pluripotent stem cell-derived cardiac progenitor cells. The agonists did not proliferate human cardiac fibroblasts, the major cell type in the heart but did proliferate human pluripotent stem cells, HuES6, in a time-of-differentiation-dependent manner.
    Materialart: Online-Ressource
    ISSN: 2157-6564 , 2157-6580
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 2020
    ZDB Id: 2642270-0
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Online-Ressource
    Online-Ressource
    Oxford University Press (OUP) ; 2019
    In:  Nucleic Acids Research Vol. 47, No. D1 ( 2019-01-08), p. D8-D14
    In: Nucleic Acids Research, Oxford University Press (OUP), Vol. 47, No. D1 ( 2019-01-08), p. D8-D14
    Materialart: Online-Ressource
    ISSN: 0305-1048 , 1362-4962
    RVK:
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 2019
    ZDB Id: 1472175-2
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    In: Human Molecular Genetics, Oxford University Press (OUP), Vol. 21, No. 9 ( 2012-5-1), p. 2132-2141
    Materialart: Online-Ressource
    ISSN: 1460-2083 , 0964-6906
    RVK:
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 2012
    ZDB Id: 1474816-2
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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