In:
Chemical Communications, Royal Society of Chemistry (RSC), Vol. 58, No. 71 ( 2022), p. 9946-9949
Abstract:
Bacteria-mediated reactions can utilize the natural activities of bacteria to produce bioactive products. Here, bacteria-mediated polymerization of the acrylamide-functionalized peptide Trp-Arg-Lys (Am-WRK) afforded an antibacterial polymer, PAm-WRK, which simulates the cationic and hydrophobic structures of antimicrobial peptides. Facultative anaerobes with strong reductive abilities exhibited better reactivity and achieved selective antibacterial effects through non-covalent interactions with bacterial membranes. This bacteria-mediated synthesis of AMP-mimic polymers provides a new strategy for overcoming bacterial resistance and for the in situ generation of bioactive functional materials.
Type of Medium:
Online Resource
ISSN:
1359-7345
,
1364-548X
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2022
detail.hit.zdb_id:
1472881-3
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