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  • Royal Society of Chemistry (RSC)  (17)
  • Wang, Ji  (17)
  • 2020-2024  (17)
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  • Royal Society of Chemistry (RSC)  (17)
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  • 2020-2024  (17)
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  • 1
    Online Resource
    Online Resource
    Molecular dynamics investigation on the interaction of human angiotensin-converting enzyme with tetrapeptide inhibitors
    Royal Society of Chemistry (RSC) ; 2021
    In:  Physical Chemistry Chemical Physics Vol. 23, No. 11 ( 2021), p. 6685-6694
    Details
    In: Physical Chemistry Chemical Physics, Royal Society of Chemistry (RSC), Vol. 23, No. 11 ( 2021), p. 6685-6694
    Type of Medium: Online Resource
    ISSN: 1463-9076 , 1463-9084
    URL: Article
    DOI: 10.1039/D1CP00172H
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2021
    detail.hit.zdb_id: 1476283-3
    detail.hit.zdb_id: 1476244-4
    detail.hit.zdb_id: 1460656-2
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  • 2
    Online Resource
    Online Resource
    Unveiling the strong dependence of the α -relaxation dispersion on mixing thermodynamics in binary glass-forming liquids
    Royal Society of Chemistry (RSC) ; 2021
    In:  Physical Chemistry Chemical Physics Vol. 23, No. 9 ( 2021), p. 5644-5651
    Details
    In: Physical Chemistry Chemical Physics, Royal Society of Chemistry (RSC), Vol. 23, No. 9 ( 2021), p. 5644-5651
    Type of Medium: Online Resource
    ISSN: 1463-9076 , 1463-9084
    URL: Article
    DOI: 10.1039/D0CP06358D
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2021
    detail.hit.zdb_id: 1476283-3
    detail.hit.zdb_id: 1476244-4
    detail.hit.zdb_id: 1460656-2
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  • 3
    Online Resource
    Online Resource
    Neuroprotective effects of fermented yak milk-derived peptide LYLKPR on H 2 O 2 -injured HT-22 cells
    Royal Society of Chemistry (RSC) ; 2022
    In:  Food & Function Vol. 13, No. 23 ( 2022), p. 12021-12038
    Details
    In: Food & Function, Royal Society of Chemistry (RSC), Vol. 13, No. 23 ( 2022), p. 12021-12038
    Abstract: This study explored the neuroprotective effect of the peptide LYLKPR derived from fermented yak milk by Lactiplantibacillus plantarum JLAU103 on H 2 O 2 -injured HT-22 cells. Peptide LYLKPR showed good stability in the simulated gastrointestinal tract and strong penetrating ability of the blood–brain barrier (BBB) in vitro . LYLKPR could activate the Nrf2/Keap-1/HO-1 pathway, increase the activities of SOD and CAT, and reduce the levels of ROS and MDA in HT-22 cells. In addition, LYLKPR controlled the activation of the NLRP3 inflammasome by inhibiting the oxidative stress, ultimately preventing the cleavage of pro-IL-18 and pro-IL-1β by caspase-1, and reducing the level of intracellular mature IL-18 by 29.08%. Based on the molecular docking verification, LYLKPR could effectively bind to the Keap-1 protein, and directly inhibit the inflammasome to significantly increase intracellular BDNF, synaptophysin, and PSD95, and protect synaptic function. Collectively, LYLKPR ameliorated oxidative stress-mediated neuronal injury by inhibiting the NLRP3 inflammasome via modulation of the Nrf2/Keap-1/HO-1 pathway.
    Type of Medium: Online Resource
    ISSN: 2042-6496 , 2042-650X
    URL: Article
    DOI: 10.1039/D2FO02131E
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2022
    detail.hit.zdb_id: 2578152-2
    SSG: 21
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  • 4
    Online Resource
    Online Resource
    Purified diet versus whole food diet and the inconsistent results in studies using animal models
    Royal Society of Chemistry (RSC) ; 2022
    In:  Food & Function Vol. 13, No. 8 ( 2022), p. 4286-4301
    Details
    In: Food & Function, Royal Society of Chemistry (RSC), Vol. 13, No. 8 ( 2022), p. 4286-4301
    Abstract: In animal models, purified diets (PDs) and whole food diets (WFDs) are used for different purposes. In similar studies, different dietary patterns may lead to inconsistent results. The aim of this study was to evaluate and compare the effects of WFDs and PDs on changes in the metabolism of mice. We found that different dietary patterns produced different results in lipid metabolism experiments. Compared with those of the PD-fed mice, the WFD-fed mice had higher body weights and serum glucose, serum lipid, and liver lipid levels ( p 〈 0.01), as well as low glucose tolerance ( p 〈 0.01) and insulin sensitivity ( p 〈 0.05). The body weight and fasting blood glucose increased by 20% in the WFD-fed mice, and the white adipose tissue weight increased by ∼50%. The WFD-fed mice also had a comparatively higher abundance of Lactobacillus , Turicibacter , Bifidobacterium , Desulfovibrio , and Candidatus saccharimonas ( p 〈 0.01), which were positively correlated with lipid accumulation. Dietary patterns should be chosen cautiously in studies that use rodents as models. Inappropriate selection of animal dietary patterns may lead to experimental systematic errors and paradoxical results.
    Type of Medium: Online Resource
    ISSN: 2042-6496 , 2042-650X
    URL: Article
    DOI: 10.1039/D1FO04311K
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2022
    detail.hit.zdb_id: 2578152-2
    SSG: 21
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  • 5
    Online Resource
    Online Resource
    Effects of ligand functionalization on the band gaps and luminescent properties of a Zr 12 oxo-cluster based metal–organic framework
    Royal Society of Chemistry (RSC) ; 2021
    In:  CrystEngComm Vol. 23, No. 16 ( 2021), p. 2961-2967
    Details
    In: CrystEngComm, Royal Society of Chemistry (RSC), Vol. 23, No. 16 ( 2021), p. 2961-2967
    Type of Medium: Online Resource
    ISSN: 1466-8033
    URL: Article
    DOI: 10.1039/D0CE01843K
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2021
    detail.hit.zdb_id: 2025075-7
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  • 6
    Online Resource
    Online Resource
    Novel disulfide bond bridged 7-ethyl-10-hydroxyl camptothecin-undecanoic acid conjugate/human serum albumin nanoparticles for breast cancer therapy
    Royal Society of Chemistry (RSC) ; 2023
    In:  Journal of Materials Chemistry B Vol. 11, No. 11 ( 2023), p. 2478-2489
    Details
    In: Journal of Materials Chemistry B, Royal Society of Chemistry (RSC), Vol. 11, No. 11 ( 2023), p. 2478-2489
    Abstract: 7-Ethyl-10-hydroxyl camptothecin (SN38), a semisynthetic derivative of camptothecin, exhibited extreme pharmacological activities in treating a range of cancers. However, its poor aqueous solubility and low stability hinder its clinical applications. Hence, a redox-responsive SN38 prodrug encapsulated human serum albumin (HSA) nanoparticle is developed to realize its potential in the clinic. First, a disulfide bond bridged 7-ethyl-10-hydroxyl camptothecin-undecanoic acid conjugate (SN38-SS-COOH) was synthesized and characterized structurally. After that, SN38-SS-COOH/HSA nanoparticles (SNH NPs) were prepared by the desolvation method. The SNH NPs with a feed molar ratio of 9 : 1 of SN38-SS-COOH : HSA showed a spherical structure with a diameter range of approximately 120–150 nm revealed by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Fluorescence quenching confirmed the formation of SNH NP complexes by dual hydrophobic force and electrostatic interaction. The SNH NPs have a high drug loading of 10.44% and an encapsulation efficiency of 89.59% with good stability. Moreover, the redox responsiveness was validated by glutathione (GSH)-triggered accelerated release of parent drug SN38. In an in vivo pharmacokinetic study, the SNH NPs exhibited a significantly prolonged circulation time ( t 1/2 , 3.77-fold) compared with free SN38. Finally, the in vivo antitumor efficacy and systemic toxicity of SNH NPs in a breast xenograft model were thoroughly evaluated. The inhibition rate of tumor growth induced by the SNH NPs reached 70.1%, while only 50.1% was achieved for irinotecan at an equivalent SN38 dosage of 10 mg kg −1 . More importantly, the SNH NPs achieved a higher level of tumor growth inhibition (85.3%) by increasing the dosage to 60 mg kg −1 SN38 without obvious adverse effects. Taken together, the use of redox-responsive SN38 prodrug/HSA NPs could be a promising strategy to deliver highly active SN38 for breast cancer chemotherapy.
    Type of Medium: Online Resource
    ISSN: 2050-750X , 2050-7518
    URL: Article
    DOI: 10.1039/D2TB02506J
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
    detail.hit.zdb_id: 2702241-9
    detail.hit.zdb_id: 2705149-3
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  • 7
    Online Resource
    Online Resource
    Host-cell-assisted construction of a folate-engineered nanocarrier based on viral light particles for targeted cancer therapy
    Royal Society of Chemistry (RSC) ; 2021
    In:  Nanoscale Vol. 13, No. 42 ( 2021), p. 17881-17889
    Details
    In: Nanoscale, Royal Society of Chemistry (RSC), Vol. 13, No. 42 ( 2021), p. 17881-17889
    Abstract: Targeted cancer therapy has aroused the broad interest of researchers due to its accuracy in specific tumor targeting and its few side effects on normal cells. In the last decades, oncolytic viral light particles (L-particles) have been transformed into smart nanocarriers for targeted drug delivery. However, these L-particles, similar to the oncolytic viruses that they are derived from, can only recognize tumor cells expressing corresponding receptors, severely limiting their universal application. Although modification of targeting agents onto their envelope can overcome this limitation, it is still a great challenge to do so without interfering with their biofunction since the envelope is fragile. Herein, a host-cell-assisted strategy is proposed to construct folate-engineered nanocarriers (F-L-particles) with their biofunctions maintained to the largest extent. The F-L-particles were further multi-functionalized by encapsulating ultrasmall near-infrared quantum dots and antitumor drugs in them for tumor real-time imaging and therapy. Such a moderate, efficient and convenient cell-based strategy facilitates the development and widespread application of these bio-nanocarriers in the field of targeted cancer therapy, and drives the interdisciplinary studies of nanotechnology, chemistry, and virology.
    Type of Medium: Online Resource
    ISSN: 2040-3364 , 2040-3372
    URL: Article
    DOI: 10.1039/D1NR04903H
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2021
    detail.hit.zdb_id: 2515664-0
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  • 8
    Online Resource
    Online Resource
    All-atom molecular dynamics simulations of the combined effects of different phospholipids and cholesterol content on electroporation
    Royal Society of Chemistry (RSC) ; 2022
    In:  RSC Advances Vol. 12, No. 38 ( 2022), p. 24491-24500
    Details
    In: RSC Advances, Royal Society of Chemistry (RSC), Vol. 12, No. 38 ( 2022), p. 24491-24500
    Abstract: The electroporation mechanism could be related to the composition of the plasma membrane, and the combined effect of different phospholipid molecules and cholesterol content on electroporation has rarely been studied nor conclusions drawn. In this paper, we applied all-atom molecular dynamics (MD) simulations to study the effects of phospholipids and cholesterol content on bilayer membrane electroporation. The palmitoyloleoylphosphatidylcholine (POPC) model, palmitoyloleoylphosphatidylethanolamine (POPE) model, and a 1 : 1 mixed model of POPC and POPE called PEPC, were the three basic models used. An electric field of 0.45 V nm −1 was applied to nine models, which were the three basic models, each with three different cholesterol content values of 0%, 24%, and 40%. The interfacial water molecules moved under the electric field and, once the first water bridge formed, the rest of the water molecules would dramatically flood into the membrane. The simulation showed that a rapid rise in the Z -component of the average dipole moment of the interfacial water molecules ( Z -DM) indicated the occurrence of electroporation, and the same increment of Z -DM represented a similar change in the size of the water bridge. With the same cholesterol content, the formation of the first water bridge was the most rapid in the POPC model, regarding the average electroporation time ( t ep ), and the average t ep of the PEPC model was close to that of the POPE model. We speculate that the differences in membrane thickness and initial number of hydrogen bonds of the interfacial water molecules affect the average t ep for different membrane compositions. Our results reveal the influence of membrane composition on the electroporation mechanism at the molecular level.
    Type of Medium: Online Resource
    ISSN: 2046-2069
    URL: Article
    DOI: 10.1039/D2RA03895A
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2022
    detail.hit.zdb_id: 2623224-8
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  • 9
    Online Resource
    Online Resource
    Theoretical investigation of weak absorption and laser induced damage in YCOB crystals
    Royal Society of Chemistry (RSC) ; 2022
    In:  CrystEngComm Vol. 24, No. 27 ( 2022), p. 4983-4990
    Details
    In: CrystEngComm, Royal Society of Chemistry (RSC), Vol. 24, No. 27 ( 2022), p. 4983-4990
    Abstract: Weak absorption and laser-induced damage in crystals have been extensively studied, but the mechanism of these phenomena is still not well understood. Herein, we investigated the weak absorption and laser-induced damage in YCOB based on inelastic electron collisions using the one-dimensional quantum waveguide theory. The barrier strengths of precursor defects were calculated directly using the results of conventional weak absorption and laser damage measurements. The effect of YCOB crystal anisotropy on weak absorption is discussed, and the barrier strengths of precursor defects in three optical axes were calculated by the one-dimensional quantum waveguide theory, which were 0.0151 ( X ), 0.0143 ( Y ), and 0.0148 ( Z ), respectively. The damage thresholds of the crystals were 2.41 ( X ), 2.74 ( Y ), and 2.65 ( Z ) GW cm −2 . The contribution of mesoscopic clusters formed by the aggregation of precursor defects to the damage temperature was analyzed by a heat transfer model, and the barrier strength of mesoscopic defects causing crystal damage was calculated to be 0.18, and the corresponding energy absorption was 11% of the incident laser energy.
    Type of Medium: Online Resource
    ISSN: 1466-8033
    URL: Article
    DOI: 10.1039/D2CE00465H
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2022
    detail.hit.zdb_id: 2025075-7
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  • 10
    Online Resource
    Online Resource
    Distal renal tubular system-on-a-chip for studying the pathogenesis of influenza A virus-induced kidney injury
    Royal Society of Chemistry (RSC) ; 2023
    In:  Lab on a Chip Vol. 23, No. 19 ( 2023), p. 4255-4264
    Details
    In: Lab on a Chip, Royal Society of Chemistry (RSC), Vol. 23, No. 19 ( 2023), p. 4255-4264
    Abstract: Influenza A viruses typically cause acute respiratory infections in humans. However, virus-induced acute kidney injury (AKI) has dramatically increased mortality. The pathogenesis remains poorly understood due to limited disease models. Here, a distal renal tubular system-on-a-chip (dRTSC) was constructed to explore the pathogenesis. The renal tubule–vascular reabsorption interface was recapitulated by co-culturing the distal renal tubule and peritubular vessel with a collagen-coated porous membrane. To study the pathways of influenza virus entry into the kidney, dynamic tracking of fluorescence-labeled virus-infected blood vessels was performed. For the first time, the virus was shown to enter the kidney rapidly by cell-free transmission without disrupting the vascular barrier. Direct virus infection of renal tubules in dRTSC reveals disruption of tight junctions, microvilli formation, polar distribution of ion transporters, and sodium reabsorption function. This robust platform allows for a straightforward investigation of virus-induced AKI pathogenesis. The combination with single-virus tracking technology provides new insights into understanding influenza virus-induced extra-respiratory disease.
    Type of Medium: Online Resource
    ISSN: 1473-0197 , 1473-0189
    URL: Article
    DOI: 10.1039/D3LC00616F
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
    detail.hit.zdb_id: 2056646-3
    SSG: 12
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