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  • Wiley  (10)
  • Wang, Hua  (10)
  • 1
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    Online Resource
    Implementation of fragile X syndrome carrier screening during prenatal diagnosis: A pilot study at a single center
    Wiley ; 2021
    In:  Molecular Genetics & Genomic Medicine Vol. 9, No. 7 ( 2021-07)
    Details
    In: Molecular Genetics & Genomic Medicine, Wiley, Vol. 9, No. 7 ( 2021-07)
    Abstract: Fragile X syndrome (FXS) is the most common inherited form of intellectual disability. Prenatal screening of FXS allows for early identification and intervention. The present study explored the feasibility of FXS carrier screening during prenatal diagnosis for those who were not offered screening early in pregnancy or prior to conception. Methods Pregnant women to be offered amniotic fluid testing were recruited for the free voluntary carrier screening at a single center between August, 2017 and September, 2019. The number of CGG repeats in the 5’ un‐translated region of the fragile X mental retardation gene 1 ( FMR1 ) was determined. Results 4286 of 7000 (61.2%) pregnant women volunteered for the screening. Forty (0.93%), five (0.11%), and three (0.07%) carriers for intermediate mutation (45–54 repeats), premutation (55–200 repeats) and full mutation ( 〉 200 repeats) of the FMR1 gene were identified respectively. None of the detected premutation alleles were inherited by the fetuses. Of the three full mutation carrier mothers, all had a family history and one transmitted a full mutation allele to her male fetus. Conclusion Implementation of FXS carrier screening during prenatal diagnosis may be considered for the need to increase screening for FXS.
    Type of Medium: Online Resource
    ISSN: 2324-9269 , 2324-9269
    URL: Issue
    URL: Article
    DOI: 10.1002/mgg3.v9.7
    DOI: 10.1002/mgg3.1711
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2734884-2
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  • 2
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    Rechargeable Aqueous Aluminum Organic Batteries
    Wiley ; 2021
    In:  Angewandte Chemie Vol. 133, No. 11 ( 2021-03-08), p. 5858-5863
    Details
    In: Angewandte Chemie, Wiley, Vol. 133, No. 11 ( 2021-03-08), p. 5858-5863
    Abstract: Aqueous aluminum‐ion batteries (AABs) are regarded as promising next‐generation energy storage devices, and the current reported cathodes for AABs mainly focused on inorganic materials which usually implement a typical Al 3+ ions (de)insertion mechanism. However, the strong electrostatic forces between Al 3+ and the host materials usually lead to sluggish kinetics, poor reversibility and inferior cycling stability. Herein, we employ an organic compound with redox‐active moieties, phenazine (PZ), as the cathode material in AABs. Different from conventional inorganic materials confined by limited lattice spacing and rigid structure, the flexible organic molecules allow a large‐size Al‐complex co‐intercalation through reversible redox active centers (‐C=N‐) of PZ. This co‐intercalation behavior can effectively reduce desolvation penalty, and substantially lower the Coulombic repulsion during the ion (de)insertion process. Consequently, this organic cathode exhibits a high capacity and excellent cyclability, which exceeds those of most reported electrode materials for AABs. This work highlights the anion co‐intercalation chemistry of redox‐active organic materials, which is expected to boost the development of high‐performance multivalent‐ion battery systems.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v133.11
    DOI: 10.1002/ange.202011144
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 3
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    Transverse distribution of cyanobacteria in a regulated urban river
    Wiley ; 2021
    In:  Ecohydrology Vol. 14, No. 3 ( 2021-04)
    Details
    In: Ecohydrology, Wiley, Vol. 14, No. 3 ( 2021-04)
    Abstract: River eutrophication and CyanoHABs are severe problems that are often ignored because of high current speed and strong self‐purification. In this paper, Liangxi River, Taihu Basin, was selected as the research area. Combined with field investigation, a 2D water environment mathematical model was developed to simulate the chl‐a distribution in Liangxi River. An indicator (Transverse Distribution Center, TDC) and its normalized form (NTDC) to quantitatively represent material transverse distribution in rivers is proposed and coupled in the model. The calculation showed that TDC and NTDC had the property of random fluctuation, seasonal consistency, and water transfer dependence. The multiple regression equation with normalized data indicated that the maximum offset, average variation rate, and average reverting rate of Liangxi River chl‐a NTDC were most affected by the chl‐a dry matter flux ratio between tributaries and the mainstream, followed by flow and chl‐a concentration ratio. From the perspective of river morphology, for different river width change modes and river bending directions, when water flows into and out of these river sections, the chl‐a transverse distribution is subject to different specific effects. In addition, the position of nutrients and dissolved oxygen significantly affected the position of chl‐a growth when the N/P ratio was not very high. Conversely, a high N/P ratio may contribute to decrease of the chl‐a concentration. Proliferation with abundant nutrients may cause the settlement of chl‐a resulting in a decrease of chl‐a in the water column.
    Type of Medium: Online Resource
    ISSN: 1936-0584 , 1936-0592
    URL: Issue
    URL: Article
    DOI: 10.1002/eco.v14.3
    DOI: 10.1002/eco.2274
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2418105-5
    SSG: 12
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  • 4
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    Rechargeable Aqueous Aluminum Organic Batteries
    Wiley ; 2021
    In:  Angewandte Chemie International Edition Vol. 60, No. 11 ( 2021-03-08), p. 5794-5799
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 60, No. 11 ( 2021-03-08), p. 5794-5799
    Abstract: Aqueous aluminum‐ion batteries (AABs) are regarded as promising next‐generation energy storage devices, and the current reported cathodes for AABs mainly focused on inorganic materials which usually implement a typical Al 3+ ions (de)insertion mechanism. However, the strong electrostatic forces between Al 3+ and the host materials usually lead to sluggish kinetics, poor reversibility and inferior cycling stability. Herein, we employ an organic compound with redox‐active moieties, phenazine (PZ), as the cathode material in AABs. Different from conventional inorganic materials confined by limited lattice spacing and rigid structure, the flexible organic molecules allow a large‐size Al‐complex co‐intercalation through reversible redox active centers (‐C=N‐) of PZ. This co‐intercalation behavior can effectively reduce desolvation penalty, and substantially lower the Coulombic repulsion during the ion (de)insertion process. Consequently, this organic cathode exhibits a high capacity and excellent cyclability, which exceeds those of most reported electrode materials for AABs. This work highlights the anion co‐intercalation chemistry of redox‐active organic materials, which is expected to boost the development of high‐performance multivalent‐ion battery systems.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v60.11
    DOI: 10.1002/anie.202011144
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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  • 5
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    A highly selective and sensitive turn‐on fluorescent probe for the detection of Al 3 + and its bioimaging
    Wiley ; 2017
    In:  Luminescence Vol. 32, No. 5 ( 2017-08), p. 779-785
    Details
    In: Luminescence, Wiley, Vol. 32, No. 5 ( 2017-08), p. 779-785
    Abstract: A novel fluorescent sensor, 1‐((2‐hydroxynaphthalen‐1‐yl)methylene)urea ( ocn ) has been designed and applied as a highly selective and sensitive fluorescent probe for recognition of Al 3 + in Tris–HCl (pH = 7.20) solution. The probe ocn exhibits an excellent selectivity to Al 3 + over other examined metal ions, anions and amino acids with a prominent fluorescence ‘turn‐on’ at 438 nm. ocn binds to Al 3 + with a 2:1 binding stoichiometry and the detection limit was 0.3 μM. Furthermore, its capability of biological application was evaluated and the results showed that the sensor could be used to detect Al 3 + in living cells.
    Type of Medium: Online Resource
    ISSN: 1522-7235 , 1522-7243
    URL: Issue
    URL: Article
    DOI: 10.1002/bio.v32.5
    DOI: 10.1002/bio.3251
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2001819-8
    SSG: 12
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  • 6
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    Whole genome sequencing reveals translocation breakpoints disrupting TP63 gene underlying split hand/foot malformation in a Chinese family
    Wiley ; 2021
    In:  Molecular Genetics & Genomic Medicine Vol. 9, No. 3 ( 2021-03)
    Details
    In: Molecular Genetics & Genomic Medicine, Wiley, Vol. 9, No. 3 ( 2021-03)
    Abstract: Split hand/foot malformation (SHFM) is a congenital limb developmental disorder, which impairs the fine activities of hand/foot in the affected individuals seriously. SHFM is commonly inherited as an autosomal dominant disease with incomplete penetrance. Chromosomal aberrations such as copy number variations and translocations have been linked to SHFM. This study aimed to identify the genetic cause for three patients with bilateral hand and foot malformation in a Chinese family. Methods Karyotyping, single‐nucleotide polymorphism (SNP) array, whole exome sequencing, whole genome sequencing, and Sanger sequencing were applied to identify the pathogenic variant. Results Karyotyping revealed that the three patients had balanced reciprocal translocation, 46, XX, t(3;15) (q29;q22). SNP array identified no pathogenic copy number variation in the proband. Trio‐WES (fetus–mother–father) sequencing results revealed no pathogenic variants in the genes related to SHFM. Whole‐genome low‐coverage mate‐pair sequencing (WGL‐MPS), breakpoint PCR, and Sanger sequencing identified the breakpoints disrupting TP63 in the patients, but not in healthy family members. Conclusion This study firstly reports that a translocation breakpoint disrupting TP 63 contributes to the SHFM in a Chinese family, which expands our knowledge of genetic risk and counseling underlying SHFM. It provides a basis for genetic counseling and prenatal diagnosis (preimplantation genetic diagnosis) for this family.
    Type of Medium: Online Resource
    ISSN: 2324-9269 , 2324-9269
    URL: Issue
    URL: Article
    DOI: 10.1002/mgg3.v9.3
    DOI: 10.1002/mgg3.1604
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2734884-2
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  • 7
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    Clinical and molecular characterization of 12 prenatal cases of Cri‐du‐chat syndrome
    Wiley ; 2020
    In:  Molecular Genetics & Genomic Medicine Vol. 8, No. 8 ( 2020-08)
    Details
    In: Molecular Genetics & Genomic Medicine, Wiley, Vol. 8, No. 8 ( 2020-08)
    Abstract: This study aimed to define the molecular basis for 12 prenatal cases of Cri‐du‐chat syndrome (CdCS) and the potential genotyping‐phenotyping association. Methods Karyotyping and single nucleotide polymorphism array analyses for copy number variants were performed. Results Nine cases had 5p terminal deletions and three had 5p interstitial deletions, and these cases had variable deletion sizes with partial overlapping. Phenotypically, besides intrauterine growth restriction (IUGR) and brain as well as heart abnormalities, hypospadias, and lung dysplasia were observed. Potential genetic causes for specific phenotypes in these cases were identified. Conclusion This study defined the molecular bases for the patients of CdCS, which is important for genetic counseling for these families. The findings of present study expand the clinical features of CdCS in the fetal period, and provided important information for further refining the genotypic–phenotypic correlations for this syndrome.
    Type of Medium: Online Resource
    ISSN: 2324-9269 , 2324-9269
    URL: Issue
    URL: Article
    DOI: 10.1002/mgg3.v8.8
    DOI: 10.1002/mgg3.1312
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2734884-2
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  • 8
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    An Ultrafast and Stable Li‐Metal Battery Cycled at −40 °C
    Wiley ; 2023
    In:  Advanced Functional Materials Vol. 33, No. 11 ( 2023-03)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 33, No. 11 ( 2023-03)
    Abstract: Li‐metal battery (LMB) suffers from the unexpected Li dendrite growth and unstable solid‐electrolyte interphase (SEI), especially in the extreme conditions, such as high rates and low temperatures (LT). Herein, a high‐rate and stable LT LMB is realized by regulating electrolyte chemistry. A weak Li + ‐solvating solvent 2‐methyltetrahydrofuran is used as electrolyte solvent to mitigate the kinetic barrier for Li + de‐solvation. Moreover, a co‐solvent tetrahydrofuran with a high donor number is incorporated to improve the LT solubility of Li salts, achieving an improved ionic conductivity while maintaining the weak Li + ‐solvation effect. Furthermore, abundant FSI ‐ anions in contact‐ion pairs are presented, facilitating the formation of a stable LiF‐enriched SEI. Consequently, the Li||Li battery can be operated at 10 mA cm ‐2 with a small polarization of 154 mV at −40 °C. Meanwhile, an outstanding cumulative cycling capacity of 4000 mAh cm ‐2 at 8.0 mA cm ‐2 is achieved, reaching a record high level in LT alkali metal symmetric batteries. Also, rechargeable high‐rate and stable full batteries are achieved at −40 °C. This work demonstrates the superiority of electrolyte chemistry for synergistic regulation of both ion transfer kinetics and SEI toward ultrafast and stable rechargeable LMBs at LT.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v33.11
    DOI: 10.1002/adfm.202212349
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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  • 9
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    Insights into the hydrodynamics in the annular pipe of industrial‐scale top‐blown smelting furnace
    Wiley ; 2024
    In:  The Canadian Journal of Chemical Engineering
    Details
    In: The Canadian Journal of Chemical Engineering, Wiley
    Abstract: The coaxial jet consisting of swirl jet and axial jet plays a critical role in the industrial processes but is rarely investigated; therefore, it is numerically explored by means of the computational fluid dynamics (CFD) approach in the present work. The force on the swirler, axial and tangential velocity at the annular pipe outlet, and the spatial distribution of swirl number (SN) are selected to evaluate the effect of geometrical parameters on the swirling performance. The results clarify that the velocity and their azimuthal components in the transverse cross‐section can be categorized into six segments based on high/low velocity values. The coaxial jets form a weak swirl with high axial, certain tangential, and low radial velocities. x ‐ and y ‐vorticity vary within −200 to 200 s −1 . Coaxial jet mixing decays the SN. Based on the multi‐objective matrix analysis, swirler height has the largest effect on swirl performance followed by diameter, angle, and number based on analysis. Optimal parameters are 130° vane angle, 240 mm diameter, 10 vanes, and 250 mm height of the swirler.
    Type of Medium: Online Resource
    ISSN: 0008-4034 , 1939-019X
    URL: Article
    DOI: 10.1002/cjce.25160
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 240250-6
    detail.hit.zdb_id: 2119520-1
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  • 10
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    CFD investigation of flow hydrodynamics and optimization in an industrial‐scale annular lance with swirl flow
    Wiley ; 2024
    In:  The Canadian Journal of Chemical Engineering
    Details
    In: The Canadian Journal of Chemical Engineering, Wiley
    Abstract: Swirling flow has been applied in various fields due to its ability to enhance mass, heat, and momentum transfer performance. However, the generation of swirling flow occurs at the price of augmenting the pressure drop, and enhancing the friction and shear intensity of the jet with respect to the reactor wall. In the present work, the impact of geometrical configurations of the swirler on the hydrodynamics of the fluid in an industrial‐scale annular lance is investigated via the computational fluid dynamics method, with the discussion of the friction coefficient of the lance walls. It shows that the axial flow injected from the central lance is transformed into a weak swirl flow upon the introduction of swirl flow generated in the casing pipe. Within the mixing region, the interaction between axial and swirl flows results in elevated turbulent kinetic energy. Notably, under varying geometrical configuration conditions, the pressure drop between the inlet of the central pipe and the outlet is maximized. Additionally, the highest friction factor appears at a height of 1.35 m along the middle shell, with a value of 96.67.
    Type of Medium: Online Resource
    ISSN: 0008-4034 , 1939-019X
    URL: Article
    DOI: 10.1002/cjce.25274
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 240250-6
    detail.hit.zdb_id: 2119520-1
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