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  • Ovid Technologies (Wolters Kluwer Health)  (3)
  • Wang, Hongyan  (3)
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  • Ovid Technologies (Wolters Kluwer Health)  (3)
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  • 1
    Online Resource
    Online Resource
    Association between plasma endothelial microparticles and contrast-induced nephropathy in patients underwent coronary angiography
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Medicine Vol. 100, No. 28 ( 2021-07-16), p. e24004-
    Details
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 100, No. 28 ( 2021-07-16), p. e24004-
    Abstract: We aim to investigate the association between plasma endothelial microparticles (EMPs) and contrast-induced nephropathy of patients underwent coronary angiography. The patients were divided into normal renal function group and renal dysfunction group based on the estimated glomerular filtration rate (eGFR). Among the 180 cases, 117 received determination of EMP and serum creatinine after percutaneous coronary intervention (PCI) and/or coronary angiography. The patients were divided into contrast-induced-nephropathy (CIN) group and non-CIN group. EMPs collection and determination were performed, together with biochemical analysis and digital subtraction angiography (DSA) analysis. Spearman correlation showed that the expression of EMP was negatively correlated with eGFR ( r  = –0.201, P   〈  .01). The serum hypersensitive C-reactive protein (hs-CRP), cystatin C (Cys-C), uric acid (UA) were significantly higher in CIN group than that in the non CIN group. Spearman correlation showed that the expression of EMP was positively correlated with serum interleukin-6 (IL-6, r  = 0.393, P   〈  .01). The expression of EMP was positively correlated with serum hs-CRP ( r  = 0.360, P   〈  .01). Logistic regression analysis showed that the levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), eGFR, UA, and Cys-C were correlated with the incidence of contrast induced nephropathy. In patients with contrast-induced-nephropathy, the plasma EMPs were significantly increased after coronary angiography. The expression of plasma EMPs may play a role in the occurrence of contrast-induced-nephropathy.
    Type of Medium: Online Resource
    ISSN: 0025-7974 , 1536-5964
    URL: Article
    DOI: 10.1097/MD.0000000000024004
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 2049818-4
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  • 2
    Online Resource
    Online Resource
    Genetic aspects of early menopause
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Journal of Bio-X Research Vol. 2, No. 3 ( 2019-09-12), p. 105-111
    Details
    In: Journal of Bio-X Research, Ovid Technologies (Wolters Kluwer Health), Vol. 2, No. 3 ( 2019-09-12), p. 105-111
    Abstract: Menopause is a biological event associated with the complete cessation of a woman's reproductive ability. Early menopause is defined as entry into menopause between the ages of 40 and 45 years, and has a significant impact on the fertility of affected women. Early menopause is a complex and heterogeneous disorder that is influenced by multiple genetic and environmental factors, as well as the interactions between these factors. Genome-wide association study (GWAS) is a novel strategy that has recently come into use as a way to overcome the limitations of genome-wide linkage analyses and candidate gene association approaches to discover novel susceptibility loci for early menopause. GWAS has identified many new candidate genes or loci associated with early menopause. In this review, we provide an overview of the current understanding of the genetic factors associated with early menopause that have been identified by GWAS. We also discuss potential approaches that could be used in the future to identify new genes associated with early menopause.
    Type of Medium: Online Resource
    ISSN: 2096-5672 , 2577-3585
    URL: Article
    DOI: 10.1097/JBR.0000000000000043
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 3025541-7
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  • 3
    Online Resource
    Online Resource
    Hepatocellular carcinoma repression by TNFα‐mediated synergistic lethal effect of mitosis defect‐induced senescence and cell death sensitization
    Ovid Technologies (Wolters Kluwer Health) ; 2016
    In:  Hepatology Vol. 64, No. 4 ( 2016-10), p. 1105-1120
    Details
    In: Hepatology, Ovid Technologies (Wolters Kluwer Health), Vol. 64, No. 4 ( 2016-10), p. 1105-1120
    Abstract: Hepatocellular carcinoma (HCC) is a cancer lacking effective therapies. Several measures have been proposed to treat HCCs, such as senescence induction, mitotic inhibition, and cell death promotion. However, data from other cancers suggest that single use of these approaches may not be effective. Here, by genetic targeting of Survivin, an inhibitor of apoptosis protein (IAP) that plays dual roles in mitosis and cell survival, we identified a tumor necrosis factor alpha (TNFα)‐mediated synergistic lethal effect between senescence and apoptosis sensitization in malignant HCCs. Survivin deficiency results in mitosis defect‐associated senescence in HCC cells, which triggers local inflammation and increased TNFα. Survivin inactivation also sensitizes HCC cells to TNFα‐triggered cell death, which leads to marked HCC regression. Based on these findings, we designed a combination treatment using mitosis inhibitor and proapoptosis compounds. This treatment recapitulates the therapeutic effect of Survivin deletion and effectively eliminates HCCs, thus representing a potential strategy for HCC therapy. Conclusion : Survivin ablation dramatically suppresses human and mouse HCCs by triggering senescence‐associated TNFα and sensitizing HCC cells to TNFα‐induced cell death. Combined use of mitotic inhibitor and second mitochondrial‐derived activator of caspases mimetic can induce senescence‐associated TNFα and enhance TNFα‐induced cell death and synergistically eliminate HCC. (H epatology 2016;64:1105‐1120)
    Type of Medium: Online Resource
    ISSN: 0270-9139 , 1527-3350
    URL: Article
    DOI: 10.1002/hep.28637
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2016
    detail.hit.zdb_id: 1472120-X
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