GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Wiley  (8)
  • Wang, Hao  (8)
  • 1
    Online Resource
    Online Resource
    Photothermal Ring Integrated Intraocular Lens for High‐Efficient Eye Disease Treatment
    Wiley ; 2017
    In:  Advanced Materials Vol. 29, No. 34 ( 2017-09)
    Details
    In: Advanced Materials, Wiley, Vol. 29, No. 34 ( 2017-09)
    Abstract: Posterior capsule opacification (PCO) is the most common complication after cataract surgery. So far, the only method for PCO treatment is the precisely focused laser surgery. However, it causes severe complications such as physical damages and neuron impairments. Here, a nanostructured photothermal ring integrated intraocular lens ( Nano‐IOLs ) is reported, in which the rim of commercially available IOLs ( C‐IOLs ) is decorated with silica coated Au nanorods (Au@SiO 2 ), for high‐efficient prevention of PCO after cataract surgery. The Nano‐IOLs is capable of eliminating the residual lens epithelial cells (LECs) around Nano‐IOLs under mild laser treatment and block the formation of disordered LECs fibrosis, which eventually leads to the loss of vision. The Nano‐IOLs shows good biocompatibility as well as extraordinary region‐confined photothermal effect. In vivo studies reveal that PCO occurrence in rabbit models is about 30%–40% by using Nano‐IOLs , which is significantly lower than the control group that treated with C‐IOLs (100% PCO occurrence) 30 d postsurgery. To the best of our knowledge, it is the first example to integrate nanotechnology with intraocular implants aiming to clinically relevant PCO. Our findings indicate that spatial controllability of photothermal effect from nanomaterials may provide a unique way to intervene the PCO‐induced loss of vision.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v29.34
    DOI: 10.1002/adma.201701617
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 1474949-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Microenvironment‐Induced In Situ Self‐Assembly of Polymer–Peptide Conjugates That Attack Solid Tumors Deeply
    Wiley ; 2019
    In:  Angewandte Chemie International Edition Vol. 58, No. 14 ( 2019-03-26), p. 4632-4637
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 58, No. 14 ( 2019-03-26), p. 4632-4637
    Abstract: In cancer treatment, the unsatisfactory solid‐tumor penetration of nanomaterials limits their therapeutic efficacy. We employed an in vivo self‐assembly strategy and designed polymer–peptide conjugates (PPCs) that underwent an acid‐induced hydrophobicity increase with a narrow pH‐response range (from 7.4 to 6.5). In situ self‐assembly in the tumor microenvironment at appropriate molecular concentrations (around the IC 50 values of PPCs) enabled drug delivery deeper into the tumor. A cytotoxic peptide KLAK, decorated with the pH‐sensitive moiety cis ‐aconitic anhydride (CAA), and a cell‐penetrating peptide TAT were conjugated onto poly(β‐thioester) backbones to produce PT‐K‐CAA, which can penetrate deeply into solid tumors owing to its small size as a single chain. During penetration in vivo, CAA responds to the weak acid, leading to the self‐assembly of PPCs and the recovery of therapeutic activity. Therefore, a deep‐penetration ability for enhanced cancer therapy is provided by this in vivo assembly strategy.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v58.14
    DOI: 10.1002/anie.201900135
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Somatic mosaicism of androgen receptor gene in an androgen insensitivity syndrome patient conceived through assisted reproduction technique
    Wiley ; 2019
    In:  Molecular Genetics & Genomic Medicine Vol. 7, No. 10 ( 2019-10)
    Details
    In: Molecular Genetics & Genomic Medicine, Wiley, Vol. 7, No. 10 ( 2019-10)
    Abstract: Mutations of human androgen receptor ( AR ) gene are responsible for androgen insensitivity syndrome (AIS). Variable phenotypes and androgen receptor binding activity have permitted the classification of AIS into complete (CAIS), partial (PAIS), and minimal or mild (MAIS) forms. Somatic mosaicism in AIS is a rare condition which happened when de novo mutations occur after the zygotic stage. Methods Clinical evaluation, hormone measurements, and molecular analysis were performed to diagnose the patient in the study. Results A 46, XY girl who conceived through in vitro fertilization (IVF), presented with partial virilization of external genitalia, was found to have the p.C620R in heterozygosity. The variant p.C620R of AR has been previously reported in a patient with completely feminized external genitalia, which was inherited from the heterozygote carrier mother. Mutation analysis of the mother of our patient revealed that the variant was de novo and presented as a somatic mosaicism which indicated an insufficient amount of wild‐type AR in our patient. Conclusion This is the first case that AIS was caused by de novo mutation of AR in a 46, XY Disorder of Sexual Development (DSD) patient by the assisted reproduction technique (ART). The phenotype of partial virilization could be explained by AR mutation in somatic mosaicism.
    Type of Medium: Online Resource
    ISSN: 2324-9269 , 2324-9269
    URL: Issue
    URL: Article
    DOI: 10.1002/mgg3.v7.10
    DOI: 10.1002/mgg3.906
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2734884-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Differences of adrenal‐derived androgens in 5α‐reductase deficiency versus androgen insensitivity syndrome
    Wiley ; 2022
    In:  Clinical and Translational Science Vol. 15, No. 3 ( 2022-03), p. 658-666
    Details
    In: Clinical and Translational Science, Wiley, Vol. 15, No. 3 ( 2022-03), p. 658-666
    Abstract: Steroid 5α‐reductase type 2 deficiency (5α‐RD2) and androgen insensitivity syndrome (AIS) are difficult to distinguish clinically and biochemically, and adrenal‐derived androgens have not been investigated in these conditions using modern methods. The objective of the study was to compare Chinese patients with 5α‐RD2, AIS, and healthy men. Sixteen patients with 5α‐RD2, 10 patients with AIS, and 39 healthy men were included. Serum androgen profiles were compared in these subjects using liquid chromatography/tandem mass spectrometry (LC‐MS/MS). Based on clinical features and laboratory tests, 5α‐RD2 and AIS were diagnosed and confirmed by genotyping. Dihydrotestosterone (DHT) and testosterone (T) were both significantly lower in patients with 5α‐RD2 than AIS ( p 〈 0.0001). The T/DHT ratio was higher in 5α‐RD2 (4.5–88.6) than AIS (13.4–26.7) or healthy men (7.6–40.5). Using LC‐MS/MS, a cutoff T/DHT value of 27.3 correctly diagnosed 5α‐RD2 versus AIS with sensitivity 93.8% and specificity 100%. Among the adrenal‐derived 11‐oxygenated androgens, 11β‐hydroxyandrostenedione (11OHA4) and 11‐ketoandrostenedione (11KA4) were also lower in patients with 5α‐RD2 than those of patients with AIS. In contrast, 11β‐hydroxytestosterone (11OHT) was higher in 5α‐RD2 than AIS. Furthermore, a 11OHT/11OHA4 cutoff value of 0.048 could also distinguish 5α‐RD2 from AIS. Thus, both elevated T/DHT values above 27.3 and the unexpected 11‐oxygenated androgen profile, with a 11OHT/11OHA4 ratio greater than 0.048, distinguished 5α‐RD2 from AIS. These data suggest that the metabolism of both gonadal and adrenal‐derived androgens is altered in 5α‐RD2.
    Type of Medium: Online Resource
    ISSN: 1752-8054 , 1752-8062
    URL: Issue
    URL: Article
    DOI: 10.1111/cts.v15.3
    DOI: 10.1111/cts.13184
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2433157-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Intracellular Self‐Immolative Polyprodrug with Near‐Infrared Light Guided Accumulation and in Vivo Visualization of Drug Release
    Wiley ; 2022
    In:  Advanced Materials Vol. 34, No. 9 ( 2022-03)
    Details
    In: Advanced Materials, Wiley, Vol. 34, No. 9 ( 2022-03)
    Abstract: The selective accumulation and real‐time monitoring of drug release at tumor site are the key bottlenecks to the clinical translation of polyprodrug. Herein, an intracellular self‐immolative polyprodrug (PMTO) is exploited, which not only shows the enhanced cellular internalization and selective accumulation in tumor site under the mild hyperthermia triggered by laser irradiation, but also possesses the self‐monitoring drug release ability in vivo. The polyprodrug amphiphiles are synthesized by sequential esterification reaction, and hydrophilic poly(ethylene glycol) serves as blocking agent. On account of the mild hyperthermia produced by PMTO under the laser irradiation at tumor site, the cell membranous permeability increases, resulting in the enhanced cellular internalization and drug accumulation in tumor. After internalized by cells, the self‐immolative PMTO nanoparticles can release free mitoxantrone (MTO) in intracellular reductive environment, and ratiometric photoacoustic imaging based on distinct signals between MTO and PMTO is presented to trace the drug release in vivo. Finally, this self‐monitoring polyprodrug presents significant tumor suppression efficacy, which exhibits great potential for guiding the clinical medication in cancer treatment.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v34.9
    DOI: 10.1002/adma.202109528
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1474949-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Site‐Specific Construction of Long‐Term Drug Depot for Suppression of Tumor Recurrence
    Wiley ; 2019
    In:  Small Vol. 15, No. 39 ( 2019-09)
    Details
    In: Small, Wiley, Vol. 15, No. 39 ( 2019-09)
    Abstract: Local tumor recurrence after surgical resection is a critical concern in cancer therapy, and the current treatments, such as postsurgical chemotherapy, still show undesired side effects. Here a nonimplant strategy (transformation induced localization, TIL) is presented to in situ construct long‐term retentive drug depots, wherein the sustained drug release from fibrous drug depots results in highly efficient suppression of postsurgical local tumor relapse. The peptide‐based prodrug nanoparticles show favorable tumor targeting and instantly reorganize into fibrous nanostructures under overexpressed enzyme, realizing the construction of long‐term drug depot in the tumor site. After the resection surgery, the remnant cancer cells are still inhibited by the sustained drug release from the fibrous prodrug depot, effectively preventing postsurgical local recurrences. This TIL strategy shows great potential in cancer recurrence therapy and offers a novel perspective for constructing functional biomaterials in vivo.
    Type of Medium: Online Resource
    ISSN: 1613-6810 , 1613-6829
    URL: Issue
    URL: Article
    DOI: 10.1002/smll.v15.39
    DOI: 10.1002/smll.201901813
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2168935-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Microenvironment‐Induced In Situ Self‐Assembly of Polymer–Peptide Conjugates That Attack Solid Tumors Deeply
    Wiley ; 2019
    In:  Angewandte Chemie Vol. 131, No. 14 ( 2019-03-26), p. 4680-4685
    Details
    In: Angewandte Chemie, Wiley, Vol. 131, No. 14 ( 2019-03-26), p. 4680-4685
    Abstract: In cancer treatment, the unsatisfactory solid‐tumor penetration of nanomaterials limits their therapeutic efficacy. We employed an in vivo self‐assembly strategy and designed polymer–peptide conjugates (PPCs) that underwent an acid‐induced hydrophobicity increase with a narrow pH‐response range (from 7.4 to 6.5). In situ self‐assembly in the tumor microenvironment at appropriate molecular concentrations (around the IC 50 values of PPCs) enabled drug delivery deeper into the tumor. A cytotoxic peptide KLAK, decorated with the pH‐sensitive moiety cis ‐aconitic anhydride (CAA), and a cell‐penetrating peptide TAT were conjugated onto poly(β‐thioester) backbones to produce PT‐K‐CAA, which can penetrate deeply into solid tumors owing to its small size as a single chain. During penetration in vivo, CAA responds to the weak acid, leading to the self‐assembly of PPCs and the recovery of therapeutic activity. Therefore, a deep‐penetration ability for enhanced cancer therapy is provided by this in vivo assembly strategy.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v131.14
    DOI: 10.1002/ange.201900135
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Reactive Oxygen Species‐Responsive Peptide‐Drug Conjugate for Mitochondria‐Specific Chemotherapy
    Wiley ; 2022
    In:  ChemNanoMat Vol. 8, No. 4 ( 2022-04)
    Details
    In: ChemNanoMat, Wiley, Vol. 8, No. 4 ( 2022-04)
    Abstract: Chemotherapy is one of the main means in clinical cancer treatment, but the efficient and precise delivery of chemotherapeutic drugs remains a key bottleneck. The precise delivery of nanomedicines to the mitochondria may achieve unexpected therapeutic effect, and peptides are considered as a promising class of mitochondrial targeting molecules. In this paper, we reported a reactive oxygen species (ROS)‐responsive peptide‐drug conjugate (PDC, CPT‐TK‐KLAK) self‐delivery system, where a mitochondria‐targeted peptide (KLAK, sequence: (KLAKLAK) 2 ) is linked to the anticancer drug camptothecin (CPT) via a ROS responsive unit. The release amount of CPT from CPT‐TK‐KLAK in the 1 mM H 2 O 2 solution was ca. 90% in 24 h, while CPT‐CC‐KLAK barely released CPT in 1 mM H 2 O 2 solution. Therefore, after targeting to the mitochondria of HeLa cells, CPT‐TK‐KLAK can specifically release CPT under overproduced ROS, which in turn destroys mitochondria and induces ROS burst, causing HeLa cells apoptosis. As a result, CPT‐TK‐KLAK exhibits high cytotoxicity to HeLa cells with an IC 50 of 0.37 μM, which is 9‐fold lower than free CPT. This ROS‐responsive PDC can also be applied for the targeted delivery of other chemotherapeutic agents, thereby enhancing therapeutic efficacy.
    Type of Medium: Online Resource
    ISSN: 2199-692X , 2199-692X
    URL: Issue
    URL: Article
    DOI: 10.1002/cnma.v8.4
    DOI: 10.1002/cnma.202100532
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2827071-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...