In:
Journal of Applied Toxicology, Wiley, Vol. 40, No. 9 ( 2020-09), p. 1239-1247
Abstract:
Dibenzo[ a , h ]anthracene (DBA) adheres to particulate matter ≤2.5 μm. Here, we investigated the in vivo effects of low DBA doses on mouse splenocytes. DBA enhanced CD4 + and CD8 + cell proliferation and cytokine production. Nuclear factor of activated T cells (NFAT) was activated in CD4 + cells, and the nuclear factor‐kappaB and C/EBP pathways were activated in CD11b + cells. These effects were Toll‐like‐receptor‐independent. NFAT is a promising marker for evaluating the effects of polycyclic aromatic hydrocarbon exposure on T cells and T‐cell‐dependent antibody responses.
Type of Medium:
Online Resource
ISSN:
0260-437X
,
1099-1263
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
1475015-6
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