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  • SAGE Publications  (10)
  • Wang, Dan  (10)
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  • SAGE Publications  (10)
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  • 1
    Online Resource
    Online Resource
    Anti-Inflammatory and Autonomic Effects of Electroacupuncture in a Rat Model of Diet-Induced Obesity
    SAGE Publications ; 2018
    In:  Acupuncture in Medicine Vol. 36, No. 2 ( 2018-04), p. 103-109
    Details
    In: Acupuncture in Medicine, SAGE Publications, Vol. 36, No. 2 ( 2018-04), p. 103-109
    Abstract: To study the effect of electroacupuncture (EA) on the cholinergic anti-inflammatory pathway (CAP) by measurement of vagal activity in rats with high-fat diet (HFD)-induced obesity. Methods Diet-induced obesity (DIO) was induced in 30 rats by feeding them a HFD for 12 weeks. A further 10 rats fed normal food comprised the lean diet (LD) control group. DIO rats were further subdivided into three groups that received a HFD only (HFD group, n=10), a HFD plus electroacupuncture (HFD+EA group, n=10) or a HFD plus minimal acupuncture (HFD+MA group, n=10). EA and MA treatments were continued for 8 weeks. Heart rate variability (HRV) was used to measure the function of the autonomic nervous system before and after treatment. ELISA was used to determine acetylcholine (ACh) and tumour necrosis factor (TNF)-α levels in the serum. Real-time PCR was used to assess the mRNA expression of α7-subtype nicotinic acetylcholine cholinergic receptors (α7nAChRs) and TNF-α in the mesenteric white adipose tissues (MWAT). Results EA but not MA significantly reduced rats’ bodyweight. No difference was found in the low frequency (LF), high frequency (HF) and the balance between LF and HF (LF/HF) components of HRV before treatment. After the EA intervention, HF was elevated and LF/HF was reduced in the HFD+EA group comparedwith the HFD group. TNF-α in the serum and MWAT were increased in the HFD group, but were reduced in the HFD+EA group. Furthermore, EA promoted expression of α7nAChRs and ACh in the MWAT. There was no difference between the HFD and HFD+MA groups for any indices. Conclusions EA enhanced vagal activity, promoted ACh release and activated α7nAChRs in the MWAT, leading to inhibition of proinflammatory cytokine production.
    Type of Medium: Online Resource
    ISSN: 0964-5284 , 1759-9873
    URL: Article
    DOI: 10.1136/acupmed-2016-011223
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2126127-1
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  • 2
    Online Resource
    Online Resource
    Alternatively Expressed Genes Identified in the CD4 + T Cells of Allograft Rejection Mice
    SAGE Publications ; 2011
    In:  Cell Transplantation Vol. 20, No. 2 ( 2011-03), p. 333-350
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 20, No. 2 ( 2011-03), p. 333-350
    Abstract: Allograft rejection is a leading cause for the failure of allotransplantation. CD4 + T cells play critical roles in this process. The identification of genes that alternatively expressed in CD4 + T cells during allograft rejection will provide critical information for studying the mechanism of allograft rejection, finding specific gene markers for monitoring, predicting allograft rejection, and opening new ways to regulate and prevent allograft rejection. Here, we established allograft and isograft transplantation models by adoptively transferring wild-type BALB/c mouse CD4 + T cells into severe combined immunodeficient (SCID) mice with a C57BL/6 or BALB/c mouse skin graft. Using the whole transcriptome sequencing-based serial analysis of gene expression (SAGE) technology, we identified 97 increasingly and 88 decreasingly expressed genes that may play important roles in allograft rejection and tolerance. Functional classification of these genes shows that apoptosis, transcription regulation, cell growth and maintenance, and signal transduction are among the frequently changed functional groups. This study provides a genome-wide view for the candidate genes of CD4 + T cells related to allotransplantation, and this report is a good resource for further microarray studies and for identifying the specific markers that are associated with clinical organ transplantations.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.3727/096368910X552844
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2020466-8
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  • 3
    Online Resource
    Online Resource
    Investigation of the mechanical properties of the modified poly( p -phenylene benzobisoxazole) fibers based on 2-(4-aminophenyl)-1 H -benzimidazol-5-amine
    SAGE Publications ; 2018
    In:  High Performance Polymers Vol. 30, No. 5 ( 2018-06), p. 511-518
    Details
    In: High Performance Polymers, SAGE Publications, Vol. 30, No. 5 ( 2018-06), p. 511-518
    Type of Medium: Online Resource
    ISSN: 0954-0083 , 1361-6412
    URL: Article
    DOI: 10.1177/0954008317706105
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 1483713-4
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  • 4
    Online Resource
    Online Resource
    Nonlinear dynamics of asymmetrically supported supercritical rotor equipped with a dry friction damper
    SAGE Publications ; 2023
    In:  Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science Vol. 237, No. 13 ( 2023-07), p. 2954-2968
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, SAGE Publications, Vol. 237, No. 13 ( 2023-07), p. 2954-2968
    Abstract: To suppress the excessive transcritical vibration of a supercritical rotor, dry friction damper is a popular choice especially in rotorcraft and aero-engine design. In the current work, we focus on the nonlinear dynamics of asymmetrically supported supercritical rotor equipped with a dry friction damper and the influence of support asymmetry on damper’s performance. Governing equations of the rotor/damper system, which fully consider the nonlinear rub-impact and side dry friction effects, are derived. Typical results of symmetrically supported rotor/damper systems are firstly demonstrated and quantitatively compared with experimental counterparts to confirm the predicting capability of the nonlinear dry friction damper model. Afterward, influences of asymmetric direct stiffness and skew-symmetric cross-coupling stiffness are discussed. It is found that direct stiffness asymmetry deteriorates the transcritical vibration attenuation capability of the damper but reduces the width of transcritical region. For system with a severer direct stiffness asymmetry, a larger pre-tightening force is suggested to be imposed. Besides, unstable self-excited vibration induced by skew-symmetric cross-coupling stiffness is found to be well-limited by the dry friction damper within entire interested rotational speed range. Moreover, during critical speed transition, the self-excited frequency component is completely suppressed.
    Type of Medium: Online Resource
    ISSN: 0954-4062 , 2041-2983
    URL: Article
    DOI: 10.1177/09544062221145517
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2024890-8
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  • 5
    Online Resource
    Online Resource
    Aggressive posterior retinopathy of prematurity in two of the triplets: a case report
    SAGE Publications ; 2015
    In:  Scottish Medical Journal Vol. 60, No. 1 ( 2015-02), p. e11-e13
    Details
    In: Scottish Medical Journal, SAGE Publications, Vol. 60, No. 1 ( 2015-02), p. e11-e13
    Abstract: Aggressive posterior retinopathy of prematurity is identified as a rare, rapidly progressing and severe form of retinopathy of prematurity (ROP). Here, we report the diagnosis and treatment of aggressive posterior retinopathy of prematurity (APROP) in two of the triplets born at low birth weight and small gestational age. A case concerning two triplets who were born at 31 weeks’ gestational age with low birth weight and reached bilateral threshold APROP was reported. The ROP of triplets A and B had the characteristic features of aggressive diseases, which were posterior location, prominence of plus disease and rapid progression. Low birth weight and small gestational age, multiple pregnancies, pregnancy-induced hypertension and older age of the mother might account for the presentations of APROP. These cases demonstrate the importance of early screening and diagnosis in APROP infants. Prompt and adequate laser photocoagulation with a large number of high-intensity closely performed spots and early retreatment could be effective and safe for preventing the progression of APROP with plus disease in zone 1 or 2 in premature triplets.
    Type of Medium: Online Resource
    ISSN: 0036-9330 , 2045-6441
    URL: Article
    DOI: 10.1177/0036933014563461
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2141765-9
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  • 6
    Online Resource
    Online Resource
    The main contributor to the upswing of survival in locally advanced colorectal cancer: an analysis of the SEER database
    SAGE Publications ; 2019
    In:  Therapeutic Advances in Gastroenterology Vol. 12 ( 2019-01), p. 175628481986215-
    Details
    In: Therapeutic Advances in Gastroenterology, SAGE Publications, Vol. 12 ( 2019-01), p. 175628481986215-
    Abstract: There is no conclusion about the most important contributor to the upswing of locally advanced colorectal cancer (LACRC) survival. Methods: Data from the Surveillance, Epidemiology, and End Results (SEER) database was extracted to identify colorectal adenocarcinoma cancer patients at stage II and III diagnosed in the two periods 1989–1990 and 2009–2010. The statistical methods included Pearson’s chi-squared test, log-rank test, Cox regression model and propensity score matching. Results: The Cox regression model showed that hazard ratio (HR) of non-surgery dropped from 11.529 to 3.469 in right colon cancer (RCC), 5.214 to 2.652 in left colon cancer (LCC) and 3.275 to 3.269 in rectal cancer (RC) from 1989–1990 to 2009–2010. The 95% confidence intervals (CIs) for surgical resection in 2009–2010 were narrower than those in 1989–1990. HR became greater in LACRC without chemotherapy (from 1.337 to 1.779 in RCC, 1.269 to 2.017 in LCC, 1.317 to 1.811 in RC). There was no overlapping about the 95% CI of chemotherapy between the two groups. The progress of surgery was not linked to the improvement of overall survival (OS) of RCC ( p = 0.303) and RC ( p = 0.660). Chemotherapy had a significant association with OS of all colorectal cancer (CRC) patients ( p = 0.017 in RCC; p = 0.006 in LCC; p = 0.001 in RC). Conclusions: Advancements in chemotherapy regimen were the main contributor to the upswing of CRC survival. The improvements in surgery had a limited effect on improvements in CRC survival.
    Type of Medium: Online Resource
    ISSN: 1756-2848 , 1756-2848
    URL: Article
    DOI: 10.1177/1756284819862154
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2440710-0
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  • 7
    Online Resource
    Online Resource
    The Anti-tumor Effect of the Light Petroleum Extract from Pulsatilla Chinensis (Bunge) Regel
    SAGE Publications ; 2008
    In:  Natural Product Communications Vol. 3, No. 5 ( 2008-05), p. 1934578X0800300-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 3, No. 5 ( 2008-05), p. 1934578X0800300-
    Abstract: The crude ethanol extract of Pulsatilla chinensis (Bunge) Regel roots was extracted successively with light petroleum, dichloromethane and n-butanol. The light petroleum fraction (PEF) exhibited potent anti-proliferation activity on HL60 cells with an IC 50 value of 14 μg/mL. As a result, ICR mice transplanted with tumor strain S180 were employed for testing the effectiveness of drug administration of PEF. The tumor inhibitory rate was 36.7% at a dose of 20 mg/kg/d, which was higher than the positive control, which produced 31.5% inhibition. However, an unusual phenomenon was observed in that the tumor inhibitory response was reverse dose-dependent since tumor inhibition was only 19.5% at a dose of 180 mg/kg/d. GC-MS revealed that the main components of the PEF were C-19 and C-22 polyunsaturated fatty acids. Previous studies had revealed that polyunsaturated fatty acids exhibit either anti-tumor or tumor promoting activities, and so it is proposed that the effects of PEF on tumor growth is dependent on dosage.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X0800300527
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 8
    Online Resource
    Online Resource
    Valproic acid Suppresses Breast Cancer Cell Growth Through Triggering Pyruvate Kinase M2 Isoform Mediated Warburg Effect
    SAGE Publications ; 2021
    In:  Cell Transplantation Vol. 30 ( 2021-01-01), p. 096368972110275-
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 30 ( 2021-01-01), p. 096368972110275-
    Abstract: Energy metabolism programming is a hallmark of cancer, and serves as a potent target of cancer therapy. Valproic acid (VPA), a broad Class I histone deacetylases (HDACs) inhibitor, has been used as a therapeutic agent for cancer. However, the detail mechanism about the potential role of VPA on the Warburg effect in breast cancer remains unclear. In this study, we highlight that VPA significantly attenuates the Warburg effect by decreasing the expression of pyruvate kinase M2 isoform (PKM2), leading to inhibited cell proliferation and reduced colony formation in breast cancer MCF-7 and MDA-MB-231 cells. Mechanistically, Warburg effect suppression triggered by VPA was mediated by inactivation of ERK1/2 phosphorylation through reduced HDAC1 expression, resulting in suppressing breast cancer growth. In summary, we uncover a novel mechanism of VPA in regulating the Warburg effect which is essential for developing the effective approach in breast cancer therapy.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.1177/09636897211027524
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2020466-8
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  • 9
    Online Resource
    Online Resource
    Amberlyst A-26: An Efficient and Reusable Heterogeneous Catalyst for a One-pot Oxidation–Cannizarro Reaction
    SAGE Publications ; 2013
    In:  Journal of Chemical Research Vol. 37, No. 1 ( 2013-01), p. 51-52
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 37, No. 1 ( 2013-01), p. 51-52
    Abstract: Amberlyst A-26 catalyses the efficient synthesis of α-hydroxy-arylacetic acids from aryl methyl ketones in the presence of SeO 2 . After simple separation, the catalyst does not lose its activity and can be reused without significant loss in activity for at least four cycles.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.3184/174751912X13551435784584
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 3010810-X
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  • 10
    Online Resource
    Online Resource
    Synthesis, Crystal Structure and bIological Activity of 5-(4-fluorophenyl)-N,N-dimethyl-7-(trifluoromethyl)Pyrazolo[1,5-a]Pyrimidine-3-carboxamide
    SAGE Publications ; 2016
    In:  Journal of Chemical Research Vol. 40, No. 2 ( 2016-02), p. 107-109
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 40, No. 2 ( 2016-02), p. 107-109
    Abstract: The title compound, 5-(4-fluorophenyl)-N,N-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, has been synthesised by condensation of dimethylamine with 5-(4-fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a] pyrimidine-3-carboxylic acid. This intermediate was prepared from ethyl 5-amino-1H-pyrazole-4-carboxylate by cyclisation with 4,4,4-trifluoro-1-(4-fluorophenyl)butane-1,3-dione and then saponification with sodium hydroxide. The crystal structure of the title compound was determined. The compound possesses distinct effective inhibition on the proliferation of some cancer cell lines.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.3184/174751916X14532123759818
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 3010810-X
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