In:
Biomedical Optics Express, Optica Publishing Group, Vol. 12, No. 7 ( 2021-07-01), p. 4573-
Abstract:
The purpose of this study is to quantitatively assess correlations
between local geographic atrophy (GA) growth rates and local optical coherence tomography angiography (OCTA)-measured choriocapillaris (CC)
flow deficits. Thirty-eight eyes from 27 patients with GA secondary to age-related macular degeneration (AMD) were imaged with a commercial
1050 nm swept-source OCTA instrument at 3 visits, each separated by ∼6 months. Pearson correlations were computed between local GA
growth rates, estimated using a biophysical GA growth model, and local OCTA CC flow deficit percentages measured along the GA margins of the
baseline visits. The p-values associated with the null hypothesis of no Pearson correlation were estimated using a Monte Carlo permutation
scheme that incorporates the effects of spatial autocorrelation. The null hypothesis (Pearson’s ρ = 0) was
rejected at a Benjamini-Hochberg false discovery rate of 0.2 in 15 of the 114 visit pairs, 11 of which exhibited positive correlations; even
amongst these 11 visit pairs, correlations were modest ( r in [0.30, 0.53]). The presented framework appears well suited to evaluating other potential imaging biomarkers of local
GA growth rates.
Type of Medium:
Online Resource
ISSN:
2156-7085
,
2156-7085
Language:
English
Publisher:
Optica Publishing Group
Publication Date:
2021
detail.hit.zdb_id:
2572216-5
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