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  • 1
    In: CardioVascular and Interventional Radiology, Springer Science and Business Media LLC, Vol. 44, No. 4 ( 2021-04), p. 610-618
    Abstract: The aim of this retrospective study was to evaluate the feasibility of a motion correction 3D reconstruction prototype technique for C-arm computed tomography (CACT). Material and Methods We included 65 consecutive CACTs acquired during transarterial chemoembolization of 54 patients (47 m,7f; 67 ± 11.3 years). All original raw datasets (CACT Org ) underwent reconstruction with and without volume punching of high-contrast objects using a 3D image reconstruction software to compensate for motion (CACT MC_bone ;CACT MC_no bone ). Subsequently, the effect on image quality (IQ) was evaluated using objective (image sharpness metric) and subjective criteria. Subjective criteria were defined by vessel geometry, overall IQ, delineation of tumor feeders, the presence of foreign material-induced artifacts and need for additional imaging, assessed by two independent readers on a 3-(vessel geometry and overall IQ) or 2-point scale, respectively. Friedman rank-sum test and post hoc analysis in form of pairwise Wilcoxon signed-rank test were computed and inter-observer agreement analyzed using kappa test. Results Objective IQ as defined by an image sharpness metric, increased from 273.5 ± 28 (CACT Org ) to 328.5 ± 55.1 (CACT MC_bone ) and 331 ± 57.8 (CACT MC_no bone ; all p   〈  0.0001). These results could largely be confirmed by the subjective analysis, which demonstrated predominantly good and moderate inter-observer agreement, with best agreement for CACT MC_no bone in all categories (e.g., vessel geometry : CACT Org : κ  = 0.51, CACT MC_bone : κ  = 0.42, CACT MC_no bone : κ  = 0.69). Conclusion The application of a motion correction algorithm was feasible for all data sets and led to an increase in both objective and subjective IQ parameters. Level of Evidence 3
    Type of Medium: Online Resource
    ISSN: 0174-1551 , 1432-086X
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 1458490-6
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  • 2
    In: Abdominal Radiology, Springer Science and Business Media LLC, Vol. 45, No. 10 ( 2020-10), p. 3342-3351
    Abstract: To evaluate the feasibility of 2D-perfusion angiography (2D-PA) for the analysis of intra-procedural treatment response after intra-arterial prostaglandin E1 therapy in patients with non-occlusive mesenteric ischemia (NOMI). Methods Overall, 20 procedures in 18 NOMI patients were included in this retrospective case–control study. To evaluate intra-procedural splanchnic circulation changes, post-processing of digital subtraction angiography (DSA) series was performed. Regions of interest (ROIs) were placed in the superior mesenteric artery (SMA; reference), the portal vein (PV; ROI PV ), as well as the aorta next to the origin of the SMA (ROI Aorta ). Peak density (PD), time to peak (TTP), and area under the curve (AUC) were assessed, and parametric ratios ‘target ROI PD, TTP, AUC /reference ROI’ were computed and compared within treatment and control group. Additionally, a NOMI score was assessed pre- and post-treatment compared to 2D-PA. Results Vasodilator therapy leads to a significant decrease of the 2D-PA-derived values PD Aorta ( p  = 0.04) and AUC Aorta ( p  = 0.03). These findings correlated with changes of the simplified NOMI score, both for overall (4 to 1, p  〈  0.0001) and for each category. Prostaglandin application caused a significant increase of the AUC PV ( p  = 0.04) and TTP PV was accelerated without reaching statistical significance ( p  = 0.13). When compared to a control group, all 2D-PA values in the NOMI group (pre- and post-intervention) differed significantly ( p   〈  0.05) with longer TTP Aorta/PV and lower AUC Aorta/PV and PD Aorta/PV . Conclusion 2D-PA offers an objective approach to analyze immediate flow and perfusion changes following vasodilatory therapies of NOMI patients and may be a valuable tool for assessing treatment response.
    Type of Medium: Online Resource
    ISSN: 2366-004X , 2366-0058
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2845742-0
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