In:
Circulation Research, Ovid Technologies (Wolters Kluwer Health), Vol. 28, No. 5_suppl_2 ( 1971-05)
Abstract:
18-Hydroxy-ll-deoxycorticosterone (18-OH-DOC) was isolated from human adrenal vein blood in concentrations of the same magnitude as is aldosterone, and its structure was proved by a variety of methods including mass spectral analysis. Angiotensin infusions failed to evoke a rise in 18-OH-DOC secretion, whereas ACTH increased 18-OH-DOC secretion up to 20-fold. The secretion rate of 18-OH-DOC determined by isotope dilution in healthy subjects was similar to the range of aldosterone secretion. Excretion of the ring A reduced glucuronide metabolite, 18-hydroxy-tetrahydro-deoxycorticosterone (18-OH-TH DOC), in urine proved to be a valid index of secretion of 18-OH-DOC. 18-OH-DOC secretion was estimated in a variety of hypertensive disorders and found to be significantly elevated in a few (3 of 12) patients with essential hypertension, suppressed plasma renin activity, low or normal aldosterone secretion, and who had significant reduction in blood pressure with spironolactone. A single patient became normotensive on prolonged dexamethasone suppression of ACTH and 18-OH-DOC secretion. The possibility that 18-OH-DOC is a precursor of some more oxygenated and, perhaps, more active mineralocorticoid is suggested.
Type of Medium:
Online Resource
ISSN:
0009-7330
,
1524-4571
DOI:
10.1161/res.28.5_suppl_2.II-143
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
1971
detail.hit.zdb_id:
1467838-X
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