In:
Journal of Dairy Research, Cambridge University Press (CUP), Vol. 66, No. 1 ( 1999-02), p. 1-8
Kurzfassung:
Plasma concentrations of the oxytocin receptor blocking agent Atosiban
were measured at 2, 4, 10, 15 and 20 min after injection of 5, 10, 20 and 50 μg
Atosiban/kg body weight in six dairy cows. The half life of Atosiban was 18 min and
the total body clearance was 3301 ml/min. Intramammary pressure (IMP) within
the teat cistern was measured in six cows before and after i.v. injection of 0 or 20 μg
Atosiban/kg body weight and repeated injections of 0·2 or 0·5 i.u. oxytocin. IMP was
also measured in eleven cows after injection of 0, 10 or 50 μg Atosiban/kg body
weight: in seven during oxytocin infusions, in four after oxytocin injections in
successively increasing dosages (0·05, 0·1, 0·2, 0·5, 1 and 10 i.u.). The occurrence of
milk ejection was indicated by a rise in IMP. After injection of 20 μg Atosiban/kg
body weight, 0·2 i.u. oxytocin did not induce an IMP rise before 48 min, whereas 0·5
i.u. oxytocin induced an IMP rise within 4 min. The time from the start of infusion
until the beginning of the IMP rise and the duration of IMP rise during oxytocin
infusions both increased, whereas the IMP rise itself was diminished by increasing
Atosiban dosages. The amount of injected oxytocin necessary to induce an IMP
response increased with increasing Atosiban dosages. Atosiban was shown to have a
powerful effect in inhibiting milk ejection in dairy cows.
Materialart:
Online-Ressource
ISSN:
0022-0299
,
1469-7629
DOI:
10.1017/S0022029998003227
Sprache:
Englisch
Verlag:
Cambridge University Press (CUP)
Publikationsdatum:
1999
ZDB Id:
2000010-8
SSG:
22
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