In:
Alzheimer's & Dementia, Wiley, Vol. 8, No. 5 ( 2012-09), p. 417-425
Abstract:
Decline of hippocampal volume on magnetic resonance imaging (MRI) may be considered as a surrogate biomarker of accumulating Alzheimer disease (AD) pathology. Previously, we showed in the prospective population‐based Rotterdam Scan Study that a higher rate of decline of hippocampal volume on MRI precedes clinical AD or memory decline. We studied potential risk factors for decline of hippocampal volume. Methods At baseline (1995–1996), 518 nondemented elderly subjects were included, and the cohort was re‐examined in 1999 and in 2006. At each examination, hippocampal volume was determined using an automated segmentation procedure. In all, 301 persons had at least two three‐dimensional MRI scans to assess decline in hippocampal volume. Results Persons carrying the apolipoprotein E ( APOE ) ε4 allele had lower hippocampal volumes than persons with the ε3/ε3 genotype, but the rate of decline was not influenced by APOE genotype. In persons who did not use antihypertensive treatment, both a high ( 〉 90 mm Hg) and a low ( 〈 70 mm Hg) diastolic blood pressure were associated with a faster decline in hippocampal volume. Also, white matter lesions on baseline MRI were associated with a higher rate of decline in hippocampal volume. Conclusions In a nondemented elderly population, persons with the APOE ε4 allele have a smaller hippocampal volume but not a higher rate of decline. Rate of decline of hippocampal volume was influenced by white matter lesions and diastolic blood pressure, supporting their hypothesized role in the pathogenesis of AD.
Type of Medium:
Online Resource
ISSN:
1552-5260
,
1552-5279
DOI:
10.1016/j.jalz.2011.07.005
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
2201940-6
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