In:
Future Oncology, Future Medicine Ltd, Vol. 5, No. 7 ( 2009-09), p. 1005-1013
Abstract:
Androgens are essential for prostatic growth and development, but also play a significant role in the pathogenesis of prostate disease. The traditional view that higher testosterone levels represent a risk factor for prostate cancer (PCa) appears to have little evidentiary support. Some studies have described a relationship between lower testosterone levels and more advanced disease. Serum androgen levels, within a broad range, are thus suggested to show no association with PCa risk, whereas low rather than high serum testosterone levels have been found to be associated with advanced or high-grade disease at the time of PCa diagnosis. Dihydrotestosterone, the principal prostatic androgen, is transformed from testosterone by type 1 and type 2 5α-reductase, and therapeutic benefits may thus be potentially achieved through the inhibition of 5α-reductase.
Type of Medium:
Online Resource
ISSN:
1479-6694
,
1744-8301
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2009
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