In:
Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, SAGE Publications, Vol. 20, No. 1 ( 2000-01), p. 60-64
Abstract:
To compare body water (V) estimates from the Chertow formula (V C ), which was derived in an end-stage renal disease population, to V estimates from the Watson formulas (V W ) in continuous ambulatory peritoneal dialysis (CAPD) patients. To identify CAPD patients in whom V C is preferred to V W for clearance studies. Design Retrospective analysis of clearance studies. Setting Dialysis units of four academic medical centers. Participants 302 subjects on CAPD. Intervention 613 clearance studies by standard methods. Main Outcome Measures Comparisons between V C and V W , and between urea clearance normalized by V C [(Kt/V C ) ur ] and V W [(Kt/V W ) ur ]. Results V C exceeded V W by 3.5 ± 1.6 L ( p 〈 0.001), or 9.6% on average. This degree of overestimation of V W is in the range of body water estimates found in CAPD subjects with severe volume overload ( 〉 5% of body weight) in previous studies. Total (Kt/V W ) ur exceeded total (Kt/V C ) ur by 8.6%. By linear regression, V C = –0.589 + (1.112 x V W ), r = 0.983. V W exceeded V C in only 12 studies. Young age, short height, low body weight, and low prevalence of diabetes characterized the studies with V W 〉 V C . Total (Kt/V W ) ur was adequate (≥ 2.0 weekly) in 276 studies. Among these, 74 studies had inadequate total (Kt/V C ) ur ( 〈 2.0 weekly). By logistic regression, the predictors of inadequate (Kt/V C ) ur , when (Kt/V W ) ur was adequate, included the presence of diabetes, great height, and long duration of CAPD. Conclusions V C provides estimates of body water exceeding those provided by V W in a great majority of CAPD patients. Consequently, approximately 25% of the clearance studies that are adequate when V W is used as the normalizing parameter may be inadequate when V C is used. V C may provide a more appropriate estimate of body water than V W in CAPD patients with volume overload.
Type of Medium:
Online Resource
ISSN:
0896-8608
,
1718-4304
DOI:
10.1177/089686080002000111
Language:
English
Publisher:
SAGE Publications
Publication Date:
2000
detail.hit.zdb_id:
2075957-5
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