In:
European Journal of Endocrinology, Oxford University Press (OUP), Vol. 162, No. 1 ( 2010-01), p. 183-189
Abstract:
Concentrations of 50 and 75 nmol/l are proposed as serum 25-hydroxyvitamin D (25(OH)D) target for older people from the view of bone health. We evaluated vitamin D status of elderly Finnish women in light of these definitions, its relationship to bone mineral density (BMD) and turnover, and improvement by summer sunshine. Design Population-based study. Methods A total of 1604 ambulatory women aged 62–79 years were studied; 66% used vitamin D supplements. Serum 25(OH)D 3 was measured with HPLC before and after summer, and heel BMD in spring. In subgroups, serum parathyroid hormone (PTH) and type I procollagen aminoterminal propeptide (PINP) were analyzed. Results In spring, 60.3% of the women had 25(OH)D 3 ≤50 nmol/l, and the target of 75 nmol/l was reached by 9.1%. For supplement users, the respective numbers were 52.1 and 11.9%. Serum 25(OH)D 3 did not determine BMD or bone turnover measured by serum PINP. Summer sunshine increased serum 25(OH)D 3 by 17.4% ( P 〈 0.0001), but in autumn 84% of the subjects remained under the target of 75 nmol/l. In supplement users, PTH remained stable but decreased in others during summer ( P =0.025). Conclusions Vitamin D status of elderly Finnish women is suboptimal if 25(OH)D 3 levels of 50 or 75 nmol/l are used as a threshold. It is moderately increased by supplement intake and summer sunshine. However, 25(OH)D 3 concentrations did not influence bone density in terms of serum PINP and bone turnover rate.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
2010
detail.hit.zdb_id:
1485160-X
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