In:
Bulletin of the Chemical Society of Japan, Oxford University Press (OUP), Vol. 69, No. 5 ( 1996-05-01), p. 1371-1376
Abstract:
A new and improved method for the preparation of the key cyclization precursors for novel pyrido[3,2,1-ij]cinnoline antibacterial agents that avoids the use of di-t-butyl methylenemalonate is described. The key process is the alkylation of 1-[N-(hydroxymethyl)-N-methylamino] -4-quinolones with di-t-butyl malonate via the intermediate chloromethyl derivatives. Unexpectedly, this process produced labile pyrazolo[1,5-a]quinoline derivatives that were subsequently shown to undergo ring opening and cyclization to C8 to produce the pyrido[3,2,1-ij] cinnoline key intermediates.
Type of Medium:
Online Resource
ISSN:
0009-2673
,
1348-0634
DOI:
10.1246/bcsj.69.1371
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
1996
detail.hit.zdb_id:
160244-5
detail.hit.zdb_id:
2041163-7
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