In:
British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 189, No. 4 ( 2006-10), p. 337-345
Abstract:
Evaluation of individuals at high genetic risk of schizophrenia is a powerful method for identifying precursors of the illness. Aims To identify aspects of personality, psychopathology and social development that differentiate high-risk and control individuals. Method Adolescent and young-adult first-degree relatives ( n =35) of people with schizophrenia or schizoaffective disorder and a control group ( n =55) were compared on 36 measures at baseline of a longitudinal study Measures differentiating high-risk and control participants were related to four genetic loading indices. Results High-risk participants older than 17 years showed more physical anhedonia, less positive involvement with peers and more problems with peers, siblings and the opposite gender. Older high-risk individuals also were less cooperative, less self-directed and less reward-dependent. Problems with peers and the opposite gender, as well as reward dependence, were related linearly to genetic loading. Conclusions Alterations in personality traits and social development are present in high-risk individuals, and may be markers for genetic liability toward the illness.
Type of Medium:
Online Resource
ISSN:
0007-1250
,
1472-1465
DOI:
10.1192/bjp.bp.105.016998
Language:
English
Publisher:
Royal College of Psychiatrists
Publication Date:
2006
detail.hit.zdb_id:
2021500-9
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