In:
Pharmacopsychiatry, Georg Thieme Verlag KG, Vol. 55, No. 02 ( 2022-03), p. 109-114
Abstract:
Introduction Pretreatment neurocognitive function may predict the
treatment response to low-dose ketamine infusion in patients with treatment-resistant depression (TRD). However, the association between working
memory function at baseline and the antidepressant efficacy of ketamine infusion remains unclear. Methods A total of 71 patients with TRD were randomized to one of three
treatment groups: 0.5 mg/kg ketamine, 0.2 mg/kg ketamine, or normal saline. Depressive symptoms were measured using the 17-item
Hamilton Depression Rating Scale (HDRS) at baseline and after treatment. Cognitive function was evaluated using working memory and go-no-go tasks at
baseline. Results A generalized linear model with adjustments for demographic
characteristics, treatment groups, and total HDRS scores at baseline revealed only a significant effect of working memory function (correct responses and
omissions) on the changes in depressive symptoms measured by HDRS at baseline (F=12.862, p 〈 0.05). Correlation analysis further showed a
negative relationship (r=0.519, p=0.027) between pretreatment working memory function and changes in HDRS scores in the
0.5 mg/kg ketamine group. Discussion An inverse relationship between pretreatment working memory
function and treatment response to ketamine infusion may confirm that low-dose ketamine infusion is beneficial and should be reserved for patients with
TRD.
Type of Medium:
Online Resource
ISSN:
0176-3679
,
1439-0795
Language:
English
Publisher:
Georg Thieme Verlag KG
Publication Date:
2022
detail.hit.zdb_id:
2041961-2
SSG:
15,3
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