In:
Catheterization and Cardiovascular Interventions, Wiley, Vol. 86, No. 3 ( 2015-09), p. 518-527
Abstract:
There is conflicting evidence on the safety and efficacy of transcatheter aortic valve implantation (TAVI) in patients with postoperative acute kidney injury (AKI). Therefore, we conducted a meta‐analysis on the impact of AKI on clinical outcomes after TAVI. Methods and Results Twenty‐four studies including 5,971 patients were analyzed. The mean incidence of AKI in this population was 22.1% ± 11.2. Postoperative AKI significantly increased early (odds ratio [OR] 5.09; 95% confidence interval [CI] , 4.03–6.43 and OR 6.14; 95% CI, 3.26–11.55) and 1‐year (OR 3.27; 95% CI, 2.42–4.42 and OR 1.93; 95% CI, 1.38–2.71) all‐cause and cardiovascular mortality respectively, but also early myocardial infarction (OR 3.30; 95% CI, 1.44–7.57), life‐threatening bleeding (OR 2.90; 95% CI, 1.67–5.05), need for transfusion (OR 2.42; 95% CI, 1.96–2.99), and dialysis (OR 14.35; 95% CI, 6.21–33.20), with a non‐significant increase of stroke (OR 1.66; 95% CI, 0.94–2.95), hospitalization (mean difference [MD] 1.73; 95% CI, −0.31 to 3.77) and contrast medium received (MD 4.74; 95% CI, −2.33 to 11.81). Conclusions Postoperative AKI seems to significantly worsen TAVI prognosis. The results of the present meta‐analysis should be considered hypothesis‐generating and future studies on risk stratification, prevention, and postoperative management are needed. © 2015 Wiley Periodicals, Inc.
Type of Medium:
Online Resource
ISSN:
1522-1946
,
1522-726X
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2001555-0
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