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  • 1
    Online Resource
    Online Resource
    Genome-wide methylation profiling in decitabine-treated patients with acute myeloid leukemia
    American Society of Hematology ; 2012
    In:  Blood Vol. 120, No. 12 ( 2012-09-20), p. 2466-2474
    Details
    In: Blood, American Society of Hematology, Vol. 120, No. 12 ( 2012-09-20), p. 2466-2474
    Abstract: The outcome of older (≥ 60 years) acute myeloid leukemia (AML) patients is poor, and novel treatments are needed. In a phase 2 trial for older AML patients, low-dose (20 mg/m2 per day for 10 days) decitabine, a DNA hypomethylating azanucleoside, produced 47% complete response rate with an excellent toxicity profile. To assess the genome-wide activity of decitabine, we profiled pretreatment and post treatment (day 25/course 1) methylomes of marrow samples from patients (n = 16) participating in the trial using deep-sequencing analysis of methylated DNA captured by methyl-binding protein (MBD2). Decitabine significantly reduced global methylation compared with pretreatment baseline (P = .001). Percent marrow blasts did not correlate with global methylation levels, suggesting that hypomethylation was related to the activity of decitabine rather than to a mere decrease in leukemia burden. Hypomethylation occurred predominantly in CpG islands and CpG island-associated regions (P ranged from .03 to .04) A significant concentration (P 〈 .001) of the hypomehtylated CpG islands was found in chromosome subtelomeric regions, suggesting a differential activity of decitabine in distinct chromosome regions. Hypermethylation occurred much less frequently than hypomethylation and was associated with low CpG content regions. Decitabine-related methylation changes were concordant with those previously reported in distinct genes. In summary, our study supports the feasibility of methylome analyses as a pharmacodynamic endpoint for hypomethylating therapies.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood-2012-05-429175
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2012
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
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  • 2
    Online Resource
    Online Resource
    Methods for high-throughput MethylCap-Seq data analysis
    Springer Science and Business Media LLC ; 2012
    In:  BMC Genomics Vol. 13, No. S6 ( 2012-10)
    Details
    In: BMC Genomics, Springer Science and Business Media LLC, Vol. 13, No. S6 ( 2012-10)
    Abstract: Advances in whole genome profiling have revolutionized the cancer research field, but at the same time have raised new bioinformatics challenges. For next generation sequencing (NGS), these include data storage, computational costs, sequence processing and alignment, delineating appropriate statistical measures, and data visualization. Currently there is a lack of workflows for efficient analysis of large, MethylCap-seq datasets containing multiple sample groups. Methods The NGS application MethylCap-seq involves the in vitro capture of methylated DNA and subsequent analysis of enriched fragments by massively parallel sequencing. The workflow we describe performs MethylCap-seq experimental Quality Control (QC), sequence file processing and alignment, differential methylation analysis of multiple biological groups, hierarchical clustering, assessment of genome-wide methylation patterns, and preparation of files for data visualization. Results Here, we present a scalable, flexible workflow for MethylCap-seq QC, secondary data analysis, tertiary analysis of multiple experimental groups, and data visualization. We demonstrate the experimental QC procedure with results from a large ovarian cancer study dataset and propose parameters which can identify problematic experiments. Promoter methylation profiling and hierarchical clustering analyses are demonstrated for four groups of acute myeloid leukemia (AML) patients. We propose a Global Methylation Indicator (GMI) function to assess genome-wide changes in methylation patterns between experimental groups. We also show how the workflow facilitates data visualization in a web browser with the application Anno-J. Conclusions This workflow and its suite of features will assist biologists in conducting methylation profiling projects and facilitate meaningful biological interpretation.
    Type of Medium: Online Resource
    ISSN: 1471-2164
    URL: Article
    DOI: 10.1186/1471-2164-13-S6-S14
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2012
    detail.hit.zdb_id: 2041499-7
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    A Hierarchical Framework for Component-based Real-time Systems
    Elsevier BV ; 2005
    In:  Electronic Notes in Theoretical Computer Science Vol. 116 ( 2005-01), p. 253-266
    Details
    In: Electronic Notes in Theoretical Computer Science, Elsevier BV, Vol. 116 ( 2005-01), p. 253-266
    Type of Medium: Online Resource
    ISSN: 1571-0661
    URL: Article
    DOI: 10.1016/j.entcs.2004.02.081
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2005
    detail.hit.zdb_id: 2033227-0
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  • 4
    Online Resource
    Online Resource
    Inter-organizational interaction in Intra-Asia business: a four-country study
    Informa UK Limited ; 1998
    In:  Asia Pacific Business Review Vol. 4, No. 4 ( 1998-06), p. 36-52
    Details
    In: Asia Pacific Business Review, Informa UK Limited, Vol. 4, No. 4 ( 1998-06), p. 36-52
    Type of Medium: Online Resource
    ISSN: 1360-2381 , 1743-792X
    URL: Article
    DOI: 10.1080/13602389812331288284
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 1998
    detail.hit.zdb_id: 2072350-7
    SSG: 6,25
    SSG: 3,2
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  • 5
    Online Resource
    Online Resource
    Contactin 4 as an autism susceptibility locus
    Wiley ; 2011
    In:  Autism Research Vol. 4, No. 3 ( 2011-06), p. 189-199
    Details
    In: Autism Research, Wiley, Vol. 4, No. 3 ( 2011-06), p. 189-199
    Abstract: Structural and sequence variation have been described in several members of the contactin ( CNTN ) and contactin‐associated protein ( CNTNAP ) gene families in association with neurodevelopmental disorders, including autism. Using array comparative genome hybridization (CGH), we identified a maternally inherited ∼535 kb deletion at 3p26.3 encompassing the 5′ end of the contactin 4 gene ( CNTN4 ) in a patient with autism. Based on this finding and previous reports implicating genomic rearrangements of CNTN4 in autism spectrum disorders (ASDs) and 3p − microdeletion syndrome, we undertook sequencing of the coding regions of the gene in a local ASD cohort in comparison with a set of controls. Unique missense variants were identified in 4 of 75 unrelated individuals with ASD, as well as in 1 of 107 controls. All of the amino acid substitutions were nonsynonomous, occurred at evolutionarily conserved positions, and were, thus, felt likely to be deleterious. However, these data did not reach statistical significance, nor did the variants segregate with disease within all of the ASD families. Finally, there was no detectable difference in binding of two of the variants to the interacting protein PTPRG in vitro. Thus, additional larger studies will be necessary to determine whether CNTN4 functions as an autism susceptibility locus in combination with other genetic and/or environmental factors. Autism Res 2011,4:189–199 . © 2011 International Society for Autism Research, Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 1939-3792 , 1939-3806
    URL: Issue
    URL: Article
    DOI: 10.1002/aur.v4.3
    DOI: 10.1002/aur.184
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 2418112-2
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  • 6
    Online Resource
    Online Resource
    A study of compatibility variation across Chinese buyer‐seller relationships
    Emerald ; 2010
    In:  European Journal of Marketing Vol. 44, No. 1/2 ( 2010-02-16), p. 87-113
    Details
    In: European Journal of Marketing, Emerald, Vol. 44, No. 1/2 ( 2010-02-16), p. 87-113
    Abstract: The purpose of this paper is to study compatibility variations in buyer‐seller relationships between Mainland Chinese firms and Hong Kong Chinese buyer firms that act as intermediaries to markets in the West. Design/methodology/approach Data are drawn from 19 multiple in‐depth case study interviews with Mainland and Hong Kong Chinese firms and buyer firms from the West. Findings Compatibility dimensions that provide further evidence of factors that underpin the nature of classical‐type exchange arrangements, vis‐à‐vis relational relationships, within Chinese buyer‐seller interactions are identified. Compatibility variations based on political and legal factors are driven by interpretation and application of Chinese state laws at the business and provincial levels rather than at the national level. Mainland Chinese tend to exhibit authoritative vis‐à‐vis Confucian‐based practices and a short‐term orientation within interactions. Research limitations/implications There is a need to expand the psychic distance composite to elucidate compatibility variations within the distinct provincial business regions of China. Quantitative studies to test for compatibility variability in China business practices across China are needed next. A better understanding of the nature of classical inclinations used by the Chinese is crucial, as is an understanding of how firms, both domestic and foreign, are able to leverage classical and relational relationships within Mainland China. Practical implications Uncertainty associated with the entrepreneurial behaviours of Chinese businesspersons and a varying emphasis on traditional Confucian values in business result in a hybridisation of interactions across classical and relational types. Guanxi may be evolving beyond traditional social and personal trust as Mainland Chinese business relationships have advanced from the smaller scale CFB stage to the state‐owned enterprise stage, and now to the larger and increasingly important world trade stage. Originality/value The paper challenges shortcomings in research that has centred exclusively on the relational nature of Chinese business interactions, and it builds on previous research to study compatibility variations underpinning these Chinese interactions. It predicts a hybridisation of interactions amongst Chinese actors and provides a foundation for future quantitative research to study compatibility variations, and also classical‐type business practices across China. Increased international market awareness may also be leading to the inclusion of an economic trust factor, driving classical‐type Chinese buyer‐seller relationships, as is more characteristic of arrangements found in Western exchanges.
    Type of Medium: Online Resource
    ISSN: 0309-0566
    URL: Article
    DOI: 10.1108/03090561011008628
    Language: English
    Publisher: Emerald
    Publication Date: 2010
    detail.hit.zdb_id: 2002936-6
    SSG: 3,2
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  • 7
    Online Resource
    Online Resource
    Business communication in interactions between Mainland Chinese and Western firms through Hong Kong Chinese intermediaries
    Emerald ; 2006
    In:  European Journal of Marketing Vol. 40, No. 11/12 ( 2006-11-01), p. 1210-1235
    Details
    In: European Journal of Marketing, Emerald, Vol. 40, No. 11/12 ( 2006-11-01), p. 1210-1235
    Abstract: The paper aims to analyse the nature of business communication and its influence on relationships development between Hong Kong Chinese intermediaries sourcing from Mainland Chinese sellers involved in manufacturing for sale to Western buyer firms. Design/methodology/approach A case study‐driven methodology with purposeful sampling is applied to yield maximum variation in the sampling to elicit underlying tendencies and generative mechanisms that exist within and across the multiple cases of relationships. Findings The paper finds that Mainland Chinese sellers and Hong Kong Chinese intermediaries tend not to have the close ties that might be expected. Mainland Chinese sellers constrained their use of social information, requiring Hong Kong Chinese intermediaries to use commercial information transfers to evaluate the trustworthiness of their Mainland Chinese partners. An ingroup/outgroup bias exacerbates the modesty bias of the Mainland Chinese and also hinders learning through the transfer of technical information within these Chinese interactions. On the other hand, Western buyers tend not to prefer social information interactions with their Hong Kong Chinese intermediaries, requiring these intermediaries to emphasise commercial information interactions to evaluate the trustworthiness of their Western buyers. Research limitations/implications This research uses a restricted sample of case study respondents. Representative sampling across multiple contexts will assist in testing the generality of the findings. Practical implications For the West to source increasingly attractive manufactures from Mainland China, Hong Kong intermediaries will remain fundamentally important even though this creates further interactions. The aggregate of these multiple exchange arrangements is less problematic than would be the case if Western business were to deal directly with the Mainland Chinese. Originality/value This article sheds light on the nature of business communication interactions in a group of relationships between Hong Kong Chinese intermediaries and Mainland sellers, and buyers from the West. Implications for relationships development among the Chinese and Western actors are identified with propositions framed to guide further investigation.
    Type of Medium: Online Resource
    ISSN: 0309-0566
    URL: Article
    DOI: 10.1108/03090560610702786
    Language: English
    Publisher: Emerald
    Publication Date: 2006
    detail.hit.zdb_id: 2002936-6
    SSG: 3,2
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  • 8
    Online Resource
    Online Resource
    The Emergence of Resources Seeking Chinese Firms’ Specific Advantages in Emerging Market
    MDPI AG ; 2022
    In:  Sustainability Vol. 14, No. 14 ( 2022-07-07), p. 8345-
    Details
    In: Sustainability, MDPI AG, Vol. 14, No. 14 ( 2022-07-07), p. 8345-
    Abstract: It is argued that the role of the Chinese government to support the cross-border operations of Chinese firms is to assist these firms in overcoming their limited established brands, and their disadvantages in technology and managerial resources, which were also the reasons why such firms decided to enter emerging markets instead of developed markets. This strategic choice is preferred to avoid direct confrontation with established firms from developed countries endowed with superior ownership advantages. Therefore, Chinese resources seeking firms innovate by increasing investment in developing and emerging markets to develop unique ownership advantages for sustainable market development and competitive advantage. This research investigates the ownership advantages of resources seeking Chinese firms in these markets using the OLI theory. The paper contributes to explaining the specific advantages of Chinese MNEs when entering emerging markets. The study applied a two-stage qualitative methodology to examine Chinese firms operating in Nigeria. The first stage included an exploratory study based on interviews with key informants and experts while the second stage included a case study methodology. The study focused on resources seeking Chinese MNEs operating in Nigeria.
    Type of Medium: Online Resource
    ISSN: 2071-1050
    URL: Article
    DOI: 10.3390/su14148345
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2518383-7
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  • 9
    Online Resource
    Online Resource
    Coordinations in business interactions between Hong Kong Chinese, mainland Chinese, and Western actors
    Elsevier BV ; 2004
    In:  International Business Review Vol. 13, No. 3 ( 2004-6), p. 331-357
    Details
    In: International Business Review, Elsevier BV, Vol. 13, No. 3 ( 2004-6), p. 331-357
    Type of Medium: Online Resource
    ISSN: 0969-5931
    URL: Article
    DOI: 10.1016/j.ibusrev.2003.10.003
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2004
    detail.hit.zdb_id: 1164338-9
    detail.hit.zdb_id: 2012947-6
    SSG: 3,2
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