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  • Ovid Technologies (Wolters Kluwer Health)  (2)
  • Toyoda, Kazunori  (2)
  • 1
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 43, No. suppl_1 ( 2012-02)
    Abstract: Purpose: As transient ischemic attack (TIA) is a medical emergency associated with a high risk of early recurrent stoke, an immediate seeking medical attention is essential to reduce a risk of stroke after TIA. The purpose of this study was to investigate factors relating to an early visit to a stroke center in patients with TIA, using data of a multicenter retrospective study. Methods: The subjects of this study were TIA patients admitted to 13 stroke centers within 7 days after onset between 2008 and 2009. The diagnosis of TIA was made in this study if clinical symptoms lasted less than 24 hours, regardless of imaging findings. We compared baseline characteristics between patients visiting a stroke center within 3 hours of TIA onset (early visit, EV group) and those after the initial 3 hours (late visit, LV group), using Chi-square tests. Results: Four hundred sixty-four patients (292 men, mean age of 69 years) were registered. Of them, 240 patients (52%) belonged to the EV group and 220 (47%) used an ambulance. One hundred twenty-seven patients (27.4%) were referred from some other medical facility and 23 patients (5.0%) were from another department within the hospital. As compared to patients in the LV group, those in the EV group more commonly had motor symptoms (p 〈 0.0001) and consciousness disturbance (p = 0.0027), and were less commonly referred from some other medical facility (p 〈 0.0001) or from another department (p = 0.0057). Patients were less likely to have a past history of TIA in the EV group than in the LV group, but not significantly (p = 0.065). Conclusions: Almost half of TIA patients visited a stroke center within 3 hours after onset. Motor symptoms and consciousness disturbance were related to an early visit. Referrals from some other medical facility or department were associated with delay in a contact to stroke specialists.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    RVK:
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2012
    detail.hit.zdb_id: 1467823-8
    Location Call Number Limitation Availability
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  • 2
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 46, No. suppl_1 ( 2015-02)
    Abstract: Background and Purpose: Cerebral microbleeds (CMBs) are associated with not only higher age but also extensive white matter lesions (WMLs), indicating that CMBs could be a reflection of microangiopathy. CMBs have not yet been examined in association with cerebral blood flow (CBF) and metabolism. The purpose of this study was to clarify the relationships of CMBs with WMLs volume, and CBF and metabolism in patients with ischemic stroke. Methods: We enrolled 19 patients who had past history of non-cardioembolic stroke without severe stenosis ( 〉 50%) in major cerebral arteries (69±7 years, 9 women). We measured WMLs volume and counted the number of CMBs on a 1.5-T magnetic resonance imaging (MRI) scanner. CBF, cerebral blood volume, oxygen extraction fraction and cerebral metabolic rate of oxygen were measured with 15 O-labeled gas positron emission tomography (PET). We set 36 regions of interest (ROIs) in the cortex-subcortex regions, basal ganglia and centra semiovale in each patient on MRI. MRI was superimposed on PET images and 4 parameters of each ROI were calculated. Results: CMBs existed in 14 out of 19 patients (median 5; range 0-39). Patients were divided into 2 groups according to the number of CMBs; less than 5 as the group I (n=9) and 5 or more as the group II (n=10). WMLs volume of the group II was larger than that of the group I (median 38.4 with range of 25.1-91.5 vs. 10.0 with 4.2-73.4 ml, p=0.020). In the centra semiovale, CBF of the group II was significantly lower than that of the group I (12.5±2.5 vs. 15.7±3.5 ml/100g/min, p=0.031). In the other regions, there were no significant differences in all 4 parameters of PET between the 2 groups. Conclusions: We showed that the increases in the number of CMBs could indicate cerebral ischemia in the deep white matter of patients with non-cardioembolic stroke without major cerebral arterial stenosis.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    RVK:
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2015
    detail.hit.zdb_id: 1467823-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
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