In:
Chemotherapy, S. Karger AG, Vol. 55, No. 3 ( 2009), p. 161-167
Abstract:
〈 i 〉 Background: 〈 /i 〉 We compared the in vitro activities of tigecycline with those of other agents against 97 〈 i 〉 Streptococcus pneumoniae, 〈 /i 〉 140 〈 i 〉 Haemophilus influenzae 〈 /i 〉 and54 〈 i 〉 Moraxella catarrhalis 〈 /i 〉 strains isolated in two large university hospitals in Istanbul. 〈 i 〉 Methods: 〈 /i 〉 For analysis, the agar dilution method was used. 〈 i 〉 Results: 〈 /i 〉 For 〈 i 〉 S. pneumoniae 〈 /i 〉 isolates, 32% were not susceptible to penicillin (28.9% intermediate and 3.1% resistant). Cefotaxime, telithromycin, moxifloxacin and linezolid were fully active. Tigecycline had a 90% minimum inhibitory concentration (MIC 〈 sub 〉 90 〈 /sub 〉 ) of 0.12 μg/ml. For 〈 i 〉 H. influenzae, 〈 /i 〉 8.57% were not susceptible to ampicillin, among which 8 possessed β-lactamase (5.7%). Four (2.87%) 〈 i 〉 H. influenzae 〈 /i 〉 isolates with β-lactamase-negative and ampicillin-resistant phenotype were found. All isolates were susceptible to ceftriaxone, azithromycin, ciprofloxacin, levofloxacin and moxifloxacin. MIC 〈 sub 〉 90 〈 /sub 〉 for tigecycline was 0.5 μg/ml. Of 54 〈 i 〉 M. catarrhalis 〈 /i 〉 isolates, 88.9% possessed β-lactamase. Tigecycline and fluoroquinolones were highly active (MIC 〈 sub 〉 90 〈 /sub 〉 ≤0.12 μg/ml). 〈 i 〉 Conclusions: 〈 /i 〉 Linezolid, telithromycin, newer fluoroquinolones and tigecycline all have excellent in vitro activities against the 3 respiratory pathogens.
Type of Medium:
Online Resource
ISSN:
0009-3157
,
1421-9794
Language:
English
Publisher:
S. Karger AG
Publication Date:
2009
detail.hit.zdb_id:
1482111-4
SSG:
15,3
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