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  • 1
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    Common Prognostic Scoring Systems for Patients Presenting with Brain Metastases
    Science Repository OU ; 2020
    In:  Clinical Oncology and Research
    Details
    In: Clinical Oncology and Research, Science Repository OU
    Abstract: Brain metastases (BM) of various primaries merely remain the most prevalent type of intracranial tumors, and approximately 25% of all cancer patients are diagnosed with this poor prognostic disease condition somewhere during their treatment course. Contingent upon the general wellbeing status of the potential patient, currently available major treatment options typically include palliative radiotherapy, chemotherapy, and best supportive care. Various published studies have convincingly shown the likelihood to stratify BM patients into particular prognostic gatherings according to the conceivable combinations of multiple patients- and tumor-related characteristics; namely the prognostic scoring systems, which might be useful in the accurate prediction of survival, and thusly, the appropriate choice of the best-fit treatment alternative. In this present article, we meant to review the pros and cons of the as of now accessible and broadly acknowledged prognostic scoring systems for BMs and their clinical values.
    Type of Medium: Online Resource
    ISSN: 2613-4942 , 2613-4942
    URL: Journal
    URL: Article
    DOI: 10.31487/j.COR
    DOI: 10.31487/j.COR.2020.03.03
    Language: Unknown
    Publisher: Science Repository OU
    Publication Date: 2020
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  • 2
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    Low Systemic Inflammation Response Index Predicts Good Prognosis in Locally Advanced Pancreatic Carcinoma Patients Treated with Concurrent Chemoradiotherapy
    Hindawi Limited ; 2020
    In:  Gastroenterology Research and Practice Vol. 2020 ( 2020-07-30), p. 1-8
    Details
    In: Gastroenterology Research and Practice, Hindawi Limited, Vol. 2020 ( 2020-07-30), p. 1-8
    Abstract: Background . We investigated the prognostic significance of pretreatment systemic inflammation response index (SIRI) in locally advanced pancreatic carcinoma (LAPC) patients treated with concurrent chemoradiotherapy (CRT). Methods . Present retrospective cohort analysis investigated consecutive 154 LAPC patients who received radical CRT. The SIRI was defined as: SIRI = neutrophil × monocyte / lymphocyte   counts . Ideal SIRI cutoff(s) influencing overall survival (OS) and progression-free survival (PFS) results were sought by using receiver operating characteristic (ROC) curve analysis. The primary endpoint was the interaction between the SIRI and OS results. Results . The median follow-up, PFS, and OS durations were 14.3 (range: 2.9-74.6), 7.9 [%95 confidence interval (CI): 5.7-10.1), and 14.7 months (%95 CI: 11.4-18.0) for the entire cohort, respectively. ROC curve analyses determined the ideal SIRI cutoff that exhibiting a significant link with OS and PFS outcomes at the rounded 1.6 point (AUC: 74.3%; sensitivity: 73.8%; specificity: 70.1%).The SIRI 〈 1.6 patients ( N = 58 ) had significantly superior median PFS (13.8 versus 6.7 months; P 〈 0.001 ) and OS (28.6 versus 12.6 months; P 〈 0.001 ) lengths than SIRI ≥1.6 patients ( N = 96 ), respectively. Although the N0 (versus N1; P 〈 0.05 ) and CA 19-9 ≤90 U/mL (versus 〉 90 U/mL) appeared as the other significant associates of better OS and PFS in univariate analyses, yet the results of multivariate analyses confirmed the SIRI 〈 1.6 as the independent indicator of superior OS and PFS ( P 〈 0.001 for each). Conclusion . Pretreatment SIRI is a novel independent prognosticator that may further enhance the conventional tumor-node-metastases staging system in a more precise prediction of the OS and PFS outcomes of LAPC patients after radical CRT.
    Type of Medium: Online Resource
    ISSN: 1687-6121 , 1687-630X
    URL: Article
    DOI: 10.1155/2020/5701949
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2435460-0
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  • 3
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    Review of Osteoradionecrosis of the Jaw: Radiotherapy Modality, Technique, and Dose as Risk Factors
    MDPI AG ; 2023
    In:  Journal of Clinical Medicine Vol. 12, No. 8 ( 2023-04-21), p. 3025-
    Details
    In: Journal of Clinical Medicine, MDPI AG, Vol. 12, No. 8 ( 2023-04-21), p. 3025-
    Abstract: Radiotherapy (RT) or concurrent chemoradiotherapy (CCRT) is the cornerstone of organ-sparing or adjuvant therapy for nearly all head and neck cancers. Unfortunately, aggressive RT or CCRT can result in severe late toxicities, such as osteoradionecrosis of the jaws (ORNJ). The incidence of ORNJ is currently less than 5–6% due to advances in dental preventive care programs, RT planning systems, and RT techniques. Although numerous patient-, tumor-, and treatment-related factors may influence the incidence rates of ORNJ, RT modality (equipment), technique, and dose-volume-related factors are three of the most influential factors. This is mainly because different RT equipment and techniques have different levels of success at delivering the prescribed dose to the focal volume of the treatment while keeping the “organ at risk” safe. ORNJ risk is ultimately determined by mandibular dose, despite the RT technique and method being known predictors. Regardless of the photon delivery method, the radiobiological effects will be identical if the total dose, dose per fraction, and dose distribution within the tissue remain constant. Therefore, contemporary RT procedures mitigate this risk by reducing mandibular dosages rather than altering the ionizing radiation behavior in irradiated tissues. In light of the paucity of studies that have examined the impact of RT modality, technique, and dose-volume-related parameters, as well as their radiobiological bases, the present review aims to provide a comprehensive overview of the published literature on these specific issues to establish a common language among related disciplines and provide a more reliable comparison of research results.
    Type of Medium: Online Resource
    ISSN: 2077-0383
    URL: Article
    DOI: 10.3390/jcm12083025
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2662592-1
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  • 4
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    Systemic Inflammation Response Index Predicts Survival Outcomes in Glioblastoma Multiforme Patients Treated with Standard Stupp Protocol
    Hindawi Limited ; 2020
    In:  Journal of Immunology Research Vol. 2020 ( 2020-11-14), p. 1-10
    Details
    In: Journal of Immunology Research, Hindawi Limited, Vol. 2020 ( 2020-11-14), p. 1-10
    Abstract: Objectives. We endeavored to retrospectively assess the prognostic merit of pretreatment systemic immune response index (SIRI) in glioblastoma multiforme (GBM) patients who underwent postoperative partial brain radiotherapy (RT) and concurrent plus adjuvant temozolomide (TMZ), namely, the Stupp protocol. Methods. The records of 181 newly diagnosed GBM patients who received the postoperative Stupp protocol were retrospectively analyzed. The SIRI value for each eligible patient was calculated by utilizing the platelet, neutrophil, and lymphocyte measures obtained on the first day of treatment: SIRI = Neutrophils × Monocytes / Lymphocytes . The ideal cutoff values for SIRI connected with the progression-free- (PFS) and overall survival (OS) results were methodically searched through using the receiver operating characteristic (ROC) curve analysis. Primary and secondary end-points constituted the potential OS and PFS distinctions among the SIRI groups, respectively. Results. The ROC curve analysis labeled the ideal SIRI cutoffs at 1.74 (Area under the curve (AUC): 74.9%; sensitivity: 74.2%; specificity: 71.4%) and 1.78 (AUC: 73.6%; sensitivity: 73.1%; specificity: 70.8%) for PFS and OS status, individually. The SIRI cutoff of 1.78 of the OS status was chosen as the common cutoff for the stratification of the study population (Group 1: SIRI ≤ 1.78 ( N = 96 ) and SIRI 〉 1.78 ( N = 85 )) and further comparative PFS and OS analyses. Comparisons between the two SIRI cohorts manifested that the SIRI ≤ 1.78 cohort had altogether significantly superior median PFS (16.2 versus 6.6 months; P 〈 0.001 ) and OS (22.9 versus 12.2 months; P 〈 0.001 ) than its SIRI 〉 1.78 counterparts. The results of multivariate Cox regression analyses ratified the independent and significant alliance between a low SIRI and longer PFS ( P 〈 0.001 ) and OS ( P 〈 0.001 ) durations, respectively. Conclusions. Present results firmly counseled the pretreatment SIRI as a novel, sound, and independent predictor of survival outcomes in newly diagnosed GBM patients intended to undergo postoperative Stupp protocol.
    Type of Medium: Online Resource
    ISSN: 2314-7156 , 2314-8861
    URL: Article
    DOI: 10.1155/2020/8628540
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2817541-4
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  • 5
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    Predictive value of metabolic 18FDG-PET response on outcomes in patients with locally advanced pancreatic carcinoma treated with definitive concurrent chemoradiotherapy
    Springer Science and Business Media LLC ; 2011
    In:  BMC Gastroenterology Vol. 11, No. 1 ( 2011-12)
    Details
    In: BMC Gastroenterology, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2011-12)
    Type of Medium: Online Resource
    ISSN: 1471-230X
    URL: Article
    DOI: 10.1186/1471-230X-11-123
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2011
    detail.hit.zdb_id: 2041351-8
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  • 6
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    Sarcomatoid Carcinoma of the Urinary Bladder Treated with Adjuvant Radiotherapy: A Case Report
    SAGE Publications ; 2009
    In:  Clinical Medicine: Case Reports Vol. 2 ( 2009-01), p. CCRep.S3126-
    Details
    In: Clinical Medicine: Case Reports, SAGE Publications, Vol. 2 ( 2009-01), p. CCRep.S3126-
    Abstract: Sarcomatoid carcinoma is a rare tumor of the urinary bladder accounting for less than 0.5% of all primary urinary bladder tumors. Since the patients were presented with large tumor with extended stages, outcome was found to be poor. In order to improve local control, adjuvant local treatment may be practical. We report a rare case with sarcomatoid carcinoma of the urinary bladder diagnosed with immunuhistochemical (IHC) study and treated with 3D-conformal radiotherapy (3DCRT) post-operatively. A 55-year old female patient complained about painless hematuria for 2 months. Computed tomography of the pelvic region revealed tumor and wall thickening at the left posterolateral side of the bladder. Total cystectomy with lymph node dissection and total abdominal hysterectomy and bilateral salphingo-oopherectomy was performed and histopathological and immunohistochemical findings strongly correlate with sarcomatoid carcinoma. The patient was treated with 3D conformal radiotherapy (3DCRT) with a total dose of 59.4 Gy with 1.8 Gy fractional daily doses. Patient was alive without any local recurrence and distant metastasis 10 months after surgery.
    Type of Medium: Online Resource
    ISSN: 1178-6450
    URL: Article
    DOI: 10.4137/CCRep.S3126
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2429257-6
    detail.hit.zdb_id: 2580498-4
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  • 7
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    Initial neutrophil‐to‐lymphocyte ratio predicts radiation‐induced trismus in parotid gland cancer
    Wiley ; 2023
    In:  Oral Diseases Vol. 29, No. 7 ( 2023-10), p. 2772-2779
    Details
    In: Oral Diseases, Wiley, Vol. 29, No. 7 ( 2023-10), p. 2772-2779
    Abstract: To investigate the link between pretreatment neutrophil‐to‐lymphocyte ratio(NLR) and the incidence of radiation‐induced trismus(RIT) in parotid gland cancers(PGC) patients after postoperative radiotherapy(PORT). Method Data of PGC patients who had oral examinations before and after PORT were reviewed retrospectively. We comprised patients who had maximum mouth opening (MMO) assessments before and after PORT and complete blood count test on the first day of PORT. MMO of ≤35 mm was considered as RIT. The receiver operating characteristic (ROC) curve analysis was used to search for an ideal NLR threshold value that might be linked to RIT rates. Results Fifty‐one patients were included, with a RIT incidence of 15.7%. The NLR cutoff that showed a link with the prevalence of RIT in the ROC curve analysis was 2.7[Area under the curve (AUC):82.0%; sensitivity:87.5%; specificity:74.4%]. The patients were divided into groups based on this value:Group 1: NLR≤2.7 ( N  = 34) and;NLR  〉 2.7 ( N  = 17). In comparative analysis, the incidence of RIT was found to be statistically higher in the NLR  〉 2.7 than counterpart (35.2%vs.5.8%;r s :0.79; p   〈  .001). Also, a mean temporomandibular joint dose ≥51.0Gy was linked to increased RIT rates ( p   〈  .001). Conclusion This study showed that high pre‐PORT NLR levels were a robust and independent predictor of significantly elevated rates of RIT.
    Type of Medium: Online Resource
    ISSN: 1354-523X , 1601-0825
    URL: Issue
    URL: Article
    DOI: 10.1111/odi.v29.7
    DOI: 10.1111/odi.14429
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2008428-6
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  • 8
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    Low hemoglobin levels predict increased radiation‐induced trismus rates in nasopharyngeal cancer
    Wiley ; 2023
    In:  Oral Diseases
    Details
    In: Oral Diseases, Wiley
    Abstract: To investigate the predictive significance of hemoglobin (Hb) values in the incidence of radiation‐induced trismus (RIT) in locally advanced nasopharyngeal carcinoma (LA‐NPC) patients who received concurrent chemoradiotherapy (C‐CRT). Methods Data of LA‐NPC patients were examined before and after C‐CRT and to confirm the presence of RIT, maximum mouth openings (MMO) were measured; RIT is defined as an MMO of ≤35 mm. All Hb values were derived from complete blood count tests obtained on the first day of C‐CRT. The receiver operating characteristic (ROC) curve analysis was used to scrutinize a possible connection between pre‐treatment Hb values and RIT status. Results Two hundred and twenty three patients were included in the study and RIT was diagnosed in 46 (20.6%) patients. The Hb cutoff in ROC curve analysis that separated the patients into two groups was 12.05 g/dL [Area under the curve (AUC): 82.7%; sensitivity: 72.9%; and specificity: 71.3%] . RIT was significantly more prevalent in the Hb ≤ 12 g/dL group than in its counterpart (41.9% vs. 7.3%; p   〈  0.001). In multivariate analysis, Hb ≤ 12, anemia, pre‐C‐CRT MMO  〈  41.4 mm, and masticatory apparatus doseV58 Gy  〈  32% groups were found to be independently associated with significantly increased rates of RIT. Conclusion Low pre‐C‐CRT Hb and anemia status are novel biological markers that independently predict higher RIT rates in LA‐NPC undergoing C‐CRT.
    Type of Medium: Online Resource
    ISSN: 1354-523X , 1601-0825
    URL: Article
    DOI: 10.1111/odi.14605
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2008428-6
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  • 9
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    Five-year follow-up results for patients diagnosed with anaplastic astrocytoma and effectiveness of concomitant therapy with temozolomide for recurrent anaplastic astrocytoma
    Georg Thieme Verlag KG ; 2012
    In:  Asian Journal of Neurosurgery Vol. 7, No. 04 ( 2012-12), p. 181-190
    Details
    In: Asian Journal of Neurosurgery, Georg Thieme Verlag KG, Vol. 7, No. 04 ( 2012-12), p. 181-190
    Abstract: Background: Anaplastic astrocytoma (AA; WHO grade-III) patients determination of prognostic factors helps generating multimodal therapy protocols. For this purpose, in the Baskent University, Adana Medical Research Center, specific characteristics of AA patients who have surgery were retrospectively investigated and factors which affect prognosis has been determined. Patients and Methods: Between January 2005 and 2009, 20 patients who have AA have been evaluated retrospectively. Totally, 20 patients had 31 operations. Sixteen patients had only adjuvant radiation therapy (RT). In the postoperative period, 8 patients received adjuvant RT. Nine of 10 patients with tumor recurrence received concomitant therapy with temozolomide (ConcT with TMZ) protocol. No adjuvant therapy protocol could be applied in three patients with poor general condition in the postoperative period. Results: Median survival for patients died was 16±17 months; one year survival was 75% and five year survival 25%. After univariate analysis, preoperative Karnofsky performance score (KPS) was ≥80 ( P=0.005577FNx01), postoperative KPS was ≥80 ( P=0.003825FNx01), type of tumor resection ( P=0.001751FNx01), multiple operations ( P=0.006233FNx01), and ConcT with TMZ protocol ( P=0,005766FNx01) were all positive prognostic factors which extend the survival. Conclusions: The results of the multivariate analysis did not put forward an independent prognostic factor acting on the survival period ( P 〉 0.05).
    Type of Medium: Online Resource
    ISSN: 1793-5482 , 2248-9614
    URL: Article
    DOI: 10.4103/1793-5482.106650
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2012
    detail.hit.zdb_id: 2621446-5
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  • 10
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    Preoperative Radiosurgery in Management of Brain Metastases
    Sciencedomain International ; 2020
    In:  Journal of Cancer and Tumor International ( 2020-04-02), p. 1-11
    Details
    In: Journal of Cancer and Tumor International, Sciencedomain International, ( 2020-04-02), p. 1-11
    Abstract: Brain metastases (BMs), the most frequent intracranial tumors, are diagnosed in approximately 30% of all adult patients over the span of planned treatment against a broad spectrum of solid cancers. The prognosis of patients presenting with BM is bleak with an expected median OS of only 4-7 months. However, some particular patients’ groups may enjoy longer survival durations with effective systemic and local therapies. At present, the feasible alternatives for active management of BMs typically include the whole-brain radiotherapy (WBRT), surgery, definitive SRS, postoperative SRS, systemic chemotherapy, targeted therapies, and their combination variants. Considering the local treatment, the severe neurotoxic effects of WBRT, and the increased risk for radionecrosis and leptomeningeal dissemination after postoperative SRS and together with the ineligibility of certain patients during the postoperative period prompted the energetic quest of alternative treatment strategies for such patients. In this respect, the novel preoperative SRS (PO-SRS) was proposed to provide at least equivalent local control rates with lesser radionecrosis and leptomeningeal dissemination risk. Respecting the scarcity of related literature, the present review aimed to meticulously detail theplausible rationale and accessible evidence for the novel PO-SRS in the management of patients presenting with BMs.
    Type of Medium: Online Resource
    ISSN: 2454-7360
    URL: Article
    DOI: 10.9734/jcti/2020/v10i130117
    Language: Unknown
    Publisher: Sciencedomain International
    Publication Date: 2020
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