In:
Journal of Applied Polymer Science, Wiley, Vol. 125, No. S1 ( 2012-07-25)
Abstract:
Halloysite nanotubes (HNTs)‐coated micrometer‐sized poly(lactic‐coglycolic acid) (PLGA) microparticles were fabricated via a combined system of “Pickering‐type” emulsion route and solvent volatilization method in the absence of any molecular surfactants. Stable oil‐in‐water emulsions were prepared using HNTs as a particulate emulsifier and a dichloromethane (CH 2 Cl 2 ) solution of PLGA as an oil phase. The HNTs‐coated PLGA microparticles were fabricated by the evaporation of CH 2 Cl 2 from the emulsion, and then bare‐PLGA microparticles were prepared by removal of the HNTs. SEM with energy dispersive analysis system (EDS) study confirmed adsorption of the HNTs only at the surface of the PLGA microparticles. After washing with acid aqueous solution, there is negligibly small amount of HNTs on the bare‐PLGA microparticles. Moreover, ibuprofen (IBU) as a drug model was loaded into the bare‐PLGA microparticles. And, the release curves were nicely fitted by the Weibull equation and the release followed Fickian diffusion. The combined system of Pickering emulsion and solvent volatilization opens up a new route to fabricate a variety of microparticles. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Type of Medium:
Online Resource
ISSN:
0021-8995
,
1097-4628
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
1491105-X
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