In:
Journal of Polymer Science Part A: Polymer Chemistry, Wiley, Vol. 43, No. 11 ( 2005-06), p. 2195-2206
Abstract:
A novel cellobiose–polylysine dendrimer with reducing sugar terminals was synthesized in which the reactive reducing end of a disaccharide cellobiose was directing outward. Hexa‐ O ‐benzyl‐4′‐(1‐carboxyethyl)‐cellobioside (HBCEC) was synthesized through the reaction of a 4′‐hydroxyl group of benzyl hexa‐ O ‐benzyl‐cellobioside with methyl 2‐chloropropionate, followed by the removal of the methyl ester group. HBCEC was reacted with polylysine dendrimer generation 3 (G3) to produce benzylated cellobiose–polylysine dendrimer G3. After debenzylation, a cellobiose–polylysine dendrimer G3 was obtained in which the reducing end of the cellobiose was the terminal group of the dendrimer. For the preparation of a dendrimer‐type acquired immunodeficiency syndrome vaccine, the cellobiose–polylysine dendrimer was reacted with a tripeptide (glycyl–prolyl–leucine) and a cyclic oligopeptide from the human immunodeficiency virus by reductive amination; this produced a tripeptide‐bound cellobiose–polylysine dendrimer and an insoluble compound, respectively. The structure analysis was carried out with NMR and matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 2195–2206, 2005
Type of Medium:
Online Resource
ISSN:
0887-624X
,
1099-0518
Language:
English
Publisher:
Wiley
Publication Date:
2005
detail.hit.zdb_id:
1473076-5
detail.hit.zdb_id:
233081-7
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