In:
Respiration, S. Karger AG, Vol. 87, No. 3 ( 2014), p. 204-210
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Pulmonary function may decline after induction chemotherapy and predict perioperative complications in non-small cell lung cancer (NSCLC). The influence of adjuvant chemotherapy is largely indeterminate. 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 To assess whether adjuvant chemotherapy alters pulmonary function and impacts on treatment-related adverse events. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 In a trial on adjuvant chemotherapy (the TREAT trial), 132 patients with R0-resected NSCLC were randomised to 4 cycles of cisplatin-vinorelbine (CVb, n = 65) or cisplatin-pemetrexed (CPx, n = 67). Pulmonary function tests (forced expiratory volume in 1 s, FEV 〈 sub 〉 1 〈 /sub 〉 , forced vital capacity, FVC, total lung capacity, TLC, diffusing capacity for carbon monoxide, D 〈 smlcap 〉 LCO 〈 /smlcap 〉 , and blood gas analyses, BGA) were analysed before and 30 days after the last chemotherapy, and changes were calculated ( & #x0394; = mean differences). 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Overall, 〈 b 〉 〈 /b 〉 FVC increased significantly ( & #x0394; +290 ml, n = 76; p 〈 0.0001), while TLC did not change ( & #x0394; +220 ml, n = 41; p = 0.174). For CPx, FEV 〈 sub 〉 1 〈 /sub 〉 increased significantly ( & #x0394; +150 ml, n = 47; p = 0.0017), but not for CVb ( & #x0394; +30 ml, n = 30). D 〈 smlcap 〉 LCO 〈 /smlcap 〉 decreased only for CVb (-8%, n = 6) but not for CPx (-0.39%, n = 17; p = 0.58). BGA did not change (p = 0.99). In a Cox regression analysis, baseline pulmonary function did not influence treatment failure. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Adjuvant chemotherapy seems not to result in a decrease of pulmonary function parameters. A significant FVC increase was probably due to ongoing postoperative improvement. Decline of D 〈 smlcap 〉 LCO 〈 /smlcap 〉 was noted with CVb but not with CPx. Pulmonary function does not impact on treatment failure.
Type of Medium:
Online Resource
ISSN:
0025-7931
,
1423-0356
Language:
English
Publisher:
S. Karger AG
Publication Date:
2014
detail.hit.zdb_id:
1464419-8
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