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  • Thijssen, J. H. H.  (4)
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  • 1
    Online Resource
    Online Resource
    No effect of treatment with sodium valproate on plasma growth hormone in bromocriptine unresponsive acromegaly
    Oxford University Press (OUP) ; 1986
    In:  Acta Endocrinologica Vol. 111, No. 2 ( 1986-02), p. 162-164
    Details
    In: Acta Endocrinologica, Oxford University Press (OUP), Vol. 111, No. 2 ( 1986-02), p. 162-164
    Abstract: Abstract. Administration of sodium valproate for 6 months at a dose of 300 mg three times daily to 7 bromocriptine unresponsive acromegalic patients who all but one had been treated with pituitary surgery and/or radiotherapy in the past did not result in a significant reduction of the plasma growth hormone (GH) level or in any clinical improvement. It is concluded that sodium valproate is not suitable for the treatment of acromegalic patients who do not show a favourable response to bromocriptine.
    Type of Medium: Online Resource
    ISSN: 0804-4643 , 1479-683X
    URL: Article
    DOI: 10.1530/acta.0.1110162
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Oxford University Press (OUP)
    Publication Date: 1986
    detail.hit.zdb_id: 1485160-X
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  • 2
    Online Resource
    Online Resource
    No acute effect of pimozide on the plasma GH levels in acromegaly
    Oxford University Press (OUP) ; 1983
    In:  Acta Endocrinologica Vol. 103, No. 4 ( 1983-08), p. 461-468
    Details
    In: Acta Endocrinologica, Oxford University Press (OUP), Vol. 103, No. 4 ( 1983-08), p. 461-468
    Abstract: Abstract. In 34 acromegalic patients either untreated or inadequately treated by surgery and/or radiotherapy the plasma GH levels and plasma Prl levels were determined during 8 h after the acute administration of the dopamine agonist bromocriptine and during 150 min after the administration of the dopamine antagonist pimozide. A 50% or more suppression of the basal GH levels was arbitrarily defined as a positive response. Seventeen patients displayed a positive response to bromocriptine, 17 patients displayed a negative response to bromocriptine. Plasma Prl levels were elevated in 6 of 17 bromocriptine responders and in 2 of 17 bromocriptine nonresponders. There was no difference in the plasma GH response to pimozide administration in the patients with a positive or a negative GH response to bromocriptine. With one exception there was in no patient a positive GH response to pimozide. In further experiments the plasma GH response to pimozide was measured during 11 h in 6 bromocriptine sensitive and 6 bromocriptine insensitive patients. Again no difference was found between bromocriptine responders and non-responders. There was also no difference in the Prl response to bromocriptine or pimozide between GH responders and GH non-responders. The Prl response to pimozide was blunted in comparison to a control group. The present study does not lend support to the idea that there is a fundamental difference in the degree of hypothalamic dopaminergic control of GH or Prl secretion between bromocriptine sensitive and bromocriptine insensitive patients with acromegaly.
    Type of Medium: Online Resource
    ISSN: 0804-4643 , 1479-683X
    URL: Article
    DOI: 10.1530/acta.0.1030461
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Oxford University Press (OUP)
    Publication Date: 1983
    detail.hit.zdb_id: 1485160-X
    Location Call Number Limitation Availability
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Long-term follow-up of five untreated acromegalic patients
    Oxford University Press (OUP) ; 1984
    In:  Acta Endocrinologica Vol. 106, No. 4 ( 1984-08), p. 437-442
    Details
    In: Acta Endocrinologica, Oxford University Press (OUP), Vol. 106, No. 4 ( 1984-08), p. 437-442
    Abstract: Abstract. The present study describes the clinical, biochemical and radiological follow-up of 5 patients with acromegaly, selected from a group of 53 patients, who did not receive treatment during a follow-up period of 5–16 years. The characteristics of these patients included: 1) older age (4 cases), 2) a long history of mild symptoms and signs (4 cases), 3) absence of diabetes mellitus (5 cases), 4) relatively low plasma GH levels (3 cases). The following observations were made during follow-up: clinical activity remained constant in 3 patients and lessonned in 2 patients, the lateral fossa area as calculated from a plain lateral X-ray of the skull remained constant and plasma GH levels measured during an oral glucose tolerance test remained constant in 3 cases, decreased substantially in one case and reached low levels in another case. In this last patient a reproducible increase of plasma GH was found after oral administration of a single dose of 2.5 mg bromocriptine, suggesting complete normality of GH secretion. It is concluded that acromegaly not necessarily progresses in all patients. The results re-emphasize the importance of taking the spontaneous course of pituitary adenomas into account when assessing the effect of various treatment protocols.
    Type of Medium: Online Resource
    ISSN: 0804-4643 , 1479-683X
    URL: Article
    DOI: 10.1530/acta.0.1060437
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Oxford University Press (OUP)
    Publication Date: 1984
    detail.hit.zdb_id: 1485160-X
    Location Call Number Limitation Availability
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    Online Resource
  • 4
    Online Resource
    Online Resource
    Changes in plasma GH levels and clinical activity during bromocriptine therapy in acromegaly. The value of predictive tests
    Oxford University Press (OUP) ; 1984
    In:  Acta Endocrinologica Vol. 106, No. 2 ( 1984-06), p. 175-183
    Details
    In: Acta Endocrinologica, Oxford University Press (OUP), Vol. 106, No. 2 ( 1984-06), p. 175-183
    Abstract: Abstract. Twenty-seven patients with active acromegaly despite previous treatment by surgery and/or radiotherapy received bromocriptine in a dose of 10–20 mg daily for a period of 6–9 months. The results of chronic bromocriptine treatment were evaluated by measurement of plasma growth hormone (GH) levels during the day and by subjective and objective criteria of clinical activity. The results of chronic bromocriptine treatment were also compared with four biochemical criteria obtained before treatment e.g. basal plasma prolactin (Prl) levels and the plasma GH response to oral administration of 2.5 mg bromocriptine respectively iv administration of 200 μg TRH and 500 μg somatostatin. The main observations may be summarized as follows: 1) The mean pre-treatment GH levels during the day ranged from 6–207 mU/l. Hyperprolactinaemia was present in 6 patients. 2) During bromocriptine treatment mean plasma GH levels decreased to less than 50% in 11 patients (GH responders) whereas in 19 patients changes of mean plasma GH and of subjective criteria of clinical activity were concordant. 3) Glucose tolerance improved significantly ( P 〈 0.01) in 10 GH-responders and the urinary hydroxyproline/creatinine ratio decreased significantly ( P 〈 0.05) in 8 GH-responders. 4) Five out of 6 patients with hyperprolactinaemia belonged to the group of GHresponders. 5) A single dose of 2.5 mg bromocriptine induced a more than 50% decrease of plasma GH in 8 of 11 GH-responders and in 5 of 16 GH non-responders. 6) The iv injection of 200 μg TRH was followed by a rise of plasma GH of more than 100% in 9 of 11 GHresponders and in 6 of 16 non-responders. 7) Responsiveness to both a single dose of bromocriptine and TRH was found in 8 of 11 GH-responders and in 3 of 16 GH non-responders. Conclusions Bromocriptine is effective as adjunctive therapy when active acromegaly persists after treatment with surgery and/or radiotherapy. In general, a good correlation is found between GH responsiveness and subjective and objective criteria of clinical activity during bromocriptine treatment. Hyperprolactinaemia predicts GH responsiveness to chronic bromocriptine treatment with high specificity. The combination of a bromocriptine test and a TRH test are of best predictive value with respect to the results of chronic bromocriptine therapy in normoprolactinaemic acromegalics.
    Type of Medium: Online Resource
    ISSN: 0804-4643 , 1479-683X
    URL: Article
    DOI: 10.1530/acta.0.1060175
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Oxford University Press (OUP)
    Publication Date: 1984
    detail.hit.zdb_id: 1485160-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
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